NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Butein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Liver Carcinoma SK-HEP-1----The gelatin zymography assay indicated that butein inhibited the activity of matrix metalloproteinases 9 (MMP-9). Gelationlytic activity of MMP-9 in the zymogram was inhibited by butein in a dose-dependent manner. Thus, bothMMP -9 was down-regulated in butein-treated SK-HEP-1 cell.21770460

 






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