NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Butein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Prostate CancerLNCaP----Treatment with butein resulted in an induction of WAF1/p21 even at the lowest concentration of 10 lM with a significant increase at the highest concentration of 30 µM. Treatment of CWR22Rm1 cells with butein (10-30 µM; 48 h) also caused an increase in WAF1/p21, suggesting that the effects of butein on prostrate cancer(PCa) cells are not limited for one-cell type.22114764

 






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