NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Bullatacin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

caspase 3, apoptosis-related cysteine peptidase

Human oral carcinoma line

KBv200

-

-

-

-

The inactive caspase-3 precursors and PARP were cleaved in the presence of bullatacin.

caspase 9, apoptosis-related cysteine peptidase

Human oral carcinoma line

KBv200

-

-

-

-

The inactive caspase-9 precursors and PARP were cleaved in the presence of bullatacin.

cytochrome c

Human oral carcinoma line

KBv200

-

-

-

-

Cyt C was released from the mitochondrial compartment to the cytosol in a concentration-dependent manner after the treatment of bullatacin.

NADH oxidase

Human promyelocytic leukemia

HL-60

-

-

-

-

NADH oxidase activity of HL-60 plasma membranes was strongly inhibited by bullatacin.

NADH oxidase

Cervix Adenocarcinoma

HeLa

-

-

5-10 nM

-

NADH oxidation by HeLa plasma membranes was reduced markedly by increasing concentrations of bullatacin.

ornithine decarboxylase 1

-

-

-

-

-

-

Bullatacin, a well-known inhibitor of NADH dehydrogenase, was identified as an extremely potent inhibitor of ODC induction by both TPA and c-Myc. Also, bullatacin was a potent inhibitor of cellular ATP formation.

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.