NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: brucine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836HepatomaHep G2----To further explore the apoptotic mechanism of HepG2 cells induced by brucine, western blot was performed to examine the protein expression level of caspase-3 and cyclooxygenase-2 in brucine-treated cells. As shown Brucine induced concentration-dependent increase of caspase-3-protein abundance associated with the corresponding decrease of cyclooxygenase-2 expression.16442763

 






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