NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Beta-Lapachone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Colon AdenocarcinomaDLD-1----Bcl-2 level was markedly up-regulated by Beta-lapachone in DLD1 cells.10656873
CCNB1cyclin B1891Colon cancerSW-620----Cyclin B1 expression was prominently up-regulated, a finding consistent with the late S-and G2/M-phase arrest induced by ,B-lapachone at 24 hr post-treatment.10656873
CCNB1cyclin B1891Colon AdenocarcinomaDLD-1----Cyclin B1 was prominently down-regulated, which is consistent with the early S-phase arrest induced by beta-lapachone at 24 hr post-treatment.10656873
CCNB1cyclin B1891Colon CancerSW-480----In SW480 cells,the expression of the G2 /M phase-specific cyclin B1 was prominently down-regulated10656873
CCND1cyclin D1595Colon AdenocarcinomaDLD-1----Expression of cyclin D1 was significantly reduced in the nucleus of DLD1 cells10656873
CCND1cyclin D1595Colon CancerSW-480----Expression of cyclin D1 was significantly reduced in the nucleus of SW480 cells.10656873
CCND1cyclin D1595Colon cancerSW-620----Expression of cyclin D1 was significantly reduced in the nucleus of SW620 cells10656873
CDK1cyclin-dependent kinase 1983Colon CancerSW-480----Expression of cyclin A-associated protein kinases Cdc2, was prominently down-regulated.10656873
CDK1cyclin-dependent kinase 1983Colon cancerSW-620----Expression of cyclin B1-and cyclin A-associated protein kinases Cdc2, was prominently down-regulated.10656873
CycACyclin A39340Colon cancerSW-620----Cyclin A expression was prominently up-regulated, a finding consistent with the late S-and G2/M-phase arrest induced by ,B-lapachone at 24 hr post-treatment.10656873
CycACyclin A39340Colon CancerSW-480----In SW480 cells, the expression of the S phase-specific cyclin A was moderately up-regulated.10656873
JUNjun proto-oncogene3725LeukemiaU-937----TNF induced a 7-fold activation of AP-1 in U937 cells, and this activation was inhibited by b-lapachone in a concentration dependent manner. The beta-lapachone by itself, however, had no effect on AP-1 activation. In addition, this drug blocked not only the AP-1 activation induced by 1 nM TNF but also that induced by higher concentrations of TNF.10075082
MAPK8mitogen-activated protein kinase 85599LeukemiaU-937----The activation of AP-1 by TNF is regulated in part by JNK. JNK activation was increased 16-fold in response to TNF. However, it gradually decreased with increasing concentration of beta-lapachone and was reduced to the basal levels by 5 mM beta-lapachone. beta-lapachone by itself did not activate JNK.10075082
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790LeukemiaU-937----Although NF-kB was activated intensely by 10,000 pM TNF, beta-lapachone inhibited the activation as completely as it did at the 0.1 nM concentration. These results show that beta-lapachone is a very potent inhibitor of NF-kB activation.10075082
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792LeukemiaU-937----Beta-lapachone blocks NF-kappaB activation by blocking IkBa degradation.10075082
PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 95715Colon CancerSW-480----p27 was moderately up-regulated by Beta-lapachone in SW480 cells10656873
TP53tumor protein p537157Colon CancerSW-480----After exposure to Beta-lapachone, mutant p53 in SW480 cells was drastically down-regulated to an almost undetectable level.10656873

 






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