NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Baicalein

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ALOX12arachidonate 12-lipoxygenase239Lung CancerH-460----Baicalein suppressed the 12-Lipoxygenase protein expression after treatment with baicalein for 8 h.12-Lipoxygenase converts arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid (HETE), a bioactive lipid implicated in tumor angiogenesis, growth and metastasis. Therefore, 12-LOX may play a role in the progression of cancer in human tissue, and its inhibitors may become anticancer agents in human cancer.17050058
BAXBCL2-associated X protein581Lung CancerH-460----After treating the H460 cells with 50 µM baicalein for 4 h, the results showed a marked upregulation of the Bax protein.17050058
BCL2B-cell CLL/lymphoma 2596Lung CancerH-460----After treating the H460 cells with 50 µM baicalein for 4 h, the results showed a marked downregulation of expression of the Bcl-2 protein.17050058
BCL2B-cell CLL/lymphoma 2596Lung squamous CarcinomaCH27----The expression of Bcl-2 proform were significantly decreased after treatment with baicalein for 8 h.15868934
CASP3caspase 3, apoptosis-related cysteine peptidase836Human promyelocytic leukemiaHL-60----Baicalein induced HL-60 apoptosis via promoted caspase-3 pathway.The results indicate that activation of caspase 3 contributes to baicalein-induced apoptosis.14630128
CASP3caspase 3, apoptosis-related cysteine peptidase836Lung CancerH-460----Proform of caspase-3 was sig-nificantly decreased after treatment with 50 lM baicaleinfor 4 .17050058
CASP3caspase 3, apoptosis-related cysteine peptidase836Lung squamous CarcinomaCH27----The expression of Caspase-3 proform were significantly decreased after treatment with baicalein for 8 h.15868934
CCNB1cyclin B1891Lung CancerH-460----Levels of Cyclin B1 protein was decreased during 50 µM baicalein treatment 24 .17050058
CCNB1cyclin B1891Lung squamous CarcinomaCH27----The level of cyclin B1 protein was decreased during 50 µM baicalein treatment for 24 h. Their data indicated that G2/M-phase-regulating cyclin B1 are expressed at low levels in baicalein-induced apoptosis. The modifications of these cell cycle-associated proteins induced by baicalein appear to perturb the cell progression through the S-phase.15868934
CCND1cyclin D1595Lung squamous CarcinomaCH27----The level of cyclin D1 protein was decreased during 50µM baicalein treatment for 24 h .Their data indicated that G0/G1-phase-regulating proteins cyclin D1 and cdk 4 expressed at low levels in baicalein-induced apoptosis. The modifications of these cell cycle-associated proteins induced by baicalein appear to perturb the cell progression through the S-phase.15868934
CDK1cyclin-dependent kinase 1983Lung CancerH-460----Levels of CDK1 protein was decreased during 50 µM baicalein treatment 24 .17050058
CDK4cyclin-dependent kinase 41019Lung squamous CarcinomaCH27----The level of cdk4 protein was decreased during 50µM baicalein treatment for 24 h .Their data indicated that G0/G1-phase-regulating proteins cyclin D1 and cdk 4 expressed at low levels in baicalein-induced apoptosis. The modifications of these cell cycle-associated proteins induced by baicalein appear to perturb the cell progression through the S-phase.15868934
PARP1poly (ADP-ribose) polymerase 1142Human promyelocytic leukemiaHL-60----Baicalein promoted caspase-3 activity then leading to cleavage of poly-ADP-ribose polymerase finally leading to DNA fragmentation occurrence.14630128
TP53tumor protein p537157Lung CancerH-460----Baicalein increased p53 protein in H460 cells up to 24 h in an incubation time-dependent manner.17050058

 






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