NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: auraptene

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CCND1cyclin D1595Breast adenocarcinomaMCF-7----MCF-7 human breast carcinoma cells in culture showed that 2 h pretreatment of auraptene (10 µM) resulted in nearly a total loss of IGF-1 induced cyclin D1 expression at 8 h.19640303
COX-2cytochrome c oxidase subunit II4513Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----Auraptene showed a concentration dependent supression of COX-2 expression (IR = 44-86% at 5-20µM)11023542
PTGER3prostaglandin E receptor 3 (subtype EP3)5733Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----Auraptene showed a concentration dependent supression of PGE2 expression (IR = 20-73% at 5-20µM)11023542
TNFtumor necrosis factor7124Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.7----Auraptene at an concentration of 10 and 20 µM supressed TNF-alpha release in a concentration dependent manner by 24.9 (P<0.02) and 83.9% (P<0.001), respectively.11023542

 






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