NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: Apigenin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

cytochrome P450, family 19, subfamily A, polypeptide 1

Adrenocortical Carcinoma

H295R

20 µM

-

-

-

Apigenin inhibited aromatase activity concentration dependently in H295R cells after a 24 h exposure.A key enzyme in the synthesis of estrogens from androgens is aromatase(cytochromeP45019;CYP19.

cytochrome P450, family 19, subfamily A, polypeptide 1

Breast adenocarcinoma

MCF-7

1 µM

-

-

-

Apigenin inhibited aromatase activity with IC50 value of about 1µM.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.