NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

NPACT

Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

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Compound: Alpha-mangostin

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

cytochrome c

Breast Carcinoma

MDA-MB-231

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In order to confirm mitochondria-mediated apoptosis, levels of cytochrome c were measured by flow cytometry and Western blot. The levels of cytochrome c protein in mitochondrial fractions were significantly lower in cells treated with alpha-mangostin for 24 .

cytochrome c

Mouse mammary carcinoma

BJMC3879luc2

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The levels of cytochrome c protein in cytosolic fractions were significantly higher in cells treated with alpha-mangostin alone for 24 hour, strongly suggesting the engagement of the mitochondria-mediated apoptotic pathway.

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Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.