NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Alpha-mangostin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Mouse mammary carcinomaBJMC3879luc2----Significantly elevated caspase-3 activity was observed in BJMC3879luc2 cells treated with alpha-mangostin for 24 hour.21639868
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CarcinomaMDA-MB-231----Significantly elevated caspase-3, activity was observed in MDA-MB231 cells treated with alpha-mangostin for 24 h.22577295
CASP8caspase 8, apoptosis-related cysteine peptidase841Mouse mammary carcinomaBJMC3879luc2----Significantly elevated caspase-8 activity was observed in BJMC3879luc2 cells treated with alpha-mangostin for 24 hour.21639868
CASP8caspase 8, apoptosis-related cysteine peptidase841Breast CarcinomaMDA-MB-231----Significantly elevated caspase-8 activity was observed in MDA-MB231 cells treated with alpha-mangostin for 24 h.22577295
CASP9caspase 9, apoptosis-related cysteine peptidase842Mouse mammary carcinomaBJMC3879luc2----Significantly elevated caspase-9 activity was observed in BJMC3879luc2 cells treated with alpha-mangostin for 24 hour.21639868
CASP9caspase 9, apoptosis-related cysteine peptidase842Breast CarcinomaMDA-MB-231----Significantly elevated caspase-9 activity was observed in MDA-MB231 cells treated with alpha-mangostin for 24 h.22577295
CCND1cyclin D1595Breast CarcinomaMDA-MB-231----On Western blotting analysis, cyclin D1 (36 kDa) protein was significantly lower with alpha-mangostin for 24 h, as compared to controls.22577295
CDK2cyclin-dependent kinase 21017Breast CarcinomaMDA-MB-231----Real-time analysis revealed that the expression of p21cip1 was up-regulated and CHEK2 expression tended to increase for more than 6 h after alpha-mangostin treatment. p21cip1 is a cyclin dependent kinase inhibitor and the encoded protein binds to and inhibits the activity of cyclin-CDK2 (CDK: cyclindependent kinase.22577295
CDK4cyclin-dependent kinase 41019Breast CarcinomaMDA-MB-231----Real-time analysis revealed that the expression of p21cip1 was up-regulated and CHEK2 expression tended to increase for more than 6 h after alpha-mangostin treatment. p21cip1 is a cyclin dependent kinase inhibitor and the encoded protein binds to and inhibits the activity of cyclin-CDK2 (CDK: cyclindependent kinase.22577295
CDK6cyclin-dependent kinase 61021Breast CarcinomaMDA-MB-231----Real-time analysis revealed that the expression of p21cip1 was up-regulated and CHEK2 expression tended to increase for more than 6 h after alpha-mangostin treatment. p21cip1 is a cyclin dependent kinase inhibitor and the encoded protein binds to and inhibits the activity of cyclin-CDK2 (CDK: cyclindependent kinase.22577295
CDK7cyclin-dependent kinase 71022Breast CarcinomaMDA-MB-231----Real-time analysis revealed that the expression of p21cip1 was up-regulated and CHEK2 expression tended to increase for more than 6 h after alpha-mangostin treatment. p21cip1 is a cyclin dependent kinase inhibitor and the encoded protein binds to and inhibits the activity of cyclin-CDK2 (CDK: cyclindependent kinase.22577295
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Breast CarcinomaMDA-MB-231----Real-time analysis revealed that the expression of p21cip1 was up-regulated and CHEK2 expression tended to increase for more than 6 h after alpha-mangostin treatment.22577295
CHEK-2checkpoint kinase 211200Breast CarcinomaMDA-MB-231----Real-time analysis revealed that the CHEK2 expression tended to increase for more than 6h after a-mangostin treatment22577295
CYCScytochrome c54205Breast CarcinomaMDA-MB-231----In order to confirm mitochondria-mediated apoptosis, levels of cytochrome c were measured by flow cytometry and Western blot. The levels of cytochrome c protein in mitochondrial fractions were significantly lower in cells treated with alpha-mangostin for 24 .22577295
CYCScytochrome c54205Mouse mammary carcinomaBJMC3879luc2----The levels of cytochrome c protein in cytosolic fractions were significantly higher in cells treated with alpha-mangostin alone for 24 hour, strongly suggesting the engagement of the mitochondria-mediated apoptotic pathway.21639868
MAPK7mitogen-activated protein kinase 75598Colon AdenocarcinomaDLD-1----Human colon cancer cells showed that alpha-mangostin inhibited Erk5 phosphorylation involving the mitogen-activated protein kinase (MAPK) signaling pathway.19325754
PCNAproliferating cell nuclear antigen5111Breast CarcinomaMDA-MB-231----On Western blotting analysis, PCNA (36 kDa) was significantly lower, in cells treated with alpha-mangostin for 24 h, as compared to controls.22577295

 






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