NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Allicin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Cervical CancerSiHa----allicin-induced apoptosis is caspase-dependent, as shown by the activation of caspases-3 in SiHa cells.14757128
CASP3caspase 3, apoptosis-related cysteine peptidase836TNF sensitive murine fibroblast cellsL929----allicin-induced apoptosis is caspase-dependent, as shown by the activation of caspases-3.14757128
CASP8caspase 8, apoptosis-related cysteine peptidase841Cervical CancerSiHa----allicin-induced apoptosis is caspase-dependent, as shown by the activation of caspases-8 in SiHa cells14757128
CASP8caspase 8, apoptosis-related cysteine peptidase841TNF sensitive murine fibroblast cellsL929----allicin-induced apoptosis is caspase-dependent, as shown by the activation of caspases-8.14757128
CASP9caspase 9, apoptosis-related cysteine peptidase842Cervical CancerSiHa----allicin-induced apoptosis is caspase-dependent, as shown by the activation of caspases-9 in SiHa cells14757128
CASP9caspase 9, apoptosis-related cysteine peptidase842TNF sensitive murine fibroblast cellsL929----allicin-induced apoptosis is caspase-dependent, as shown by the activation of caspases-9.14757128
PARP1poly (ADP-ribose) polymerase 1142Cervical CancerSiHa----allicin-induced apoptosis is caspase-dependent, as shown by the activation of cleavage of poly(ADP-ribose) polymerase in SiHa cells14757128
PARP1poly (ADP-ribose) polymerase 1142TNF sensitive murine fibroblast cellsL929----allicin-induced apoptosis is caspase-dependent, as shown by the activation of cleavage of poly(ADP-ribose) polymerase.14757128

 






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