NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 6-shogaol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318HepatomaHep-3B----The activity of MMP-9 was suppressed in a dose-dependent manner, but the MMP-2 activity was not significantly changed when HepG2 and Hep3B cells were treated with 6-shogaol (1, 2.5, 5, and 10 µM),respectively. The inhibitory effect on MMP-9 in hepatoma cells by 6-shogaol may be through the regulation of both uPA and TIMP-1. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-shogaol .20521273
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318HepatomaHep G2----The activity of MMP-9 was suppressed in a dose-dependent manner, but the MMP-2 activity was not significantly changed when HepG2 and Hep3B cells were treated with 6-shogaol (1, 2.5, 5, and 10 µM),respectively. The inhibitory effect on MMP-9 in hepatoma cells by 6-shogaol may be through the regulation of both uPA and TIMP-1. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-shogaol .20521273

 






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