NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 6-Gingerol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318HepatomaHep-3B----MMP-9 mRNA expression were decreased by [6]-gingerol treatment.20521273
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318Breast CarcinomaMDA-MB-231----The activity of MMP-9 was suppressed in a dose-dependent manner, but the MMP-2 activity was not significantly changed when HepG2 and Hep3B cells were treated with 6-gingrol (5, 10, 25, and 50 µM),respectively. The inhibitory effect on MMP-9 in hepatoma cells by 6-gingroll may be through the regulation of both uPA and TIMP-1. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-gingrol .17683926
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)4318HepatomaHep G2----The activity of MMP-9 was suppressed in a dose-dependent manner, but the MMP-2 activity was not significantly changed when HepG2 and Hep3B cells were treated with 6-gingrol (5, 10, 25, and 50 µM),respectively. The inhibitory effect on MMP-9 in hepatoma cells by 6-gingroll may be through the regulation of both uPA and TIMP-1. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-gingrol .20521273

 






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