NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: [6]-gingerol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
LTA4Hleukotriene A4 hydrolase4048Colon carcinogenesisHCT116----Results showed that mice fed [6]-gingerol survived significantly longer than those receiving vehicle, implying that tumors grew much slower. At day 49, 11 of the [6]-gingerol-treated mice still had not developed tumors equal to 1 cm3. ELISA data showed that [6]- gingerol-treated tumors exhibited a much lower level of LTB4 production, suggesting that [6]-gingerol inhibits colon tumor formation by suppressing LTA4H activity in vivo19531649

 






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