NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 28-homocastasterone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Breast adenocarcinomaMCF-7----28-homocastasterone treatments caused expression of the anti-apoptotic Bcl-2 in MCF-7 cells to decrease after 12 h.20833159
BCL2B-cell CLL/lymphoma 2596Breast CarcinomaMDA-MB-468----Bcl-2 expression was slightly decreased after the 28-homoCS treatments (6, 12 and 24 h).20833159
BCL2L1BCL2-like 1598Breast adenocarcinomaMCF-7----28-homocastasterone treatments caused expression of Bcl-XL proteins in MCF-7 cells to decrease after 12 h.20833159
BIDBH3 interacting domain death agonist637Breast adenocarcinomaMCF-7----Bid expression was slightly decreased after the 28-homoCS treatments (6 h).20833159
BIDBH3 interacting domain death agonist637Breast CarcinomaMDA-MB-468----MDA-MB-468 cells showed increased levels of reductions in uncleaved Bid expression only when subjected to 6 h of treatment.20833159
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CarcinomaMDA-MB-468----The blots showed degradation of caspase-3 into cleaved fragments (part of apoptotic cascade) after 24 h of each 28-homocastasterone treatment in MDA-MB-468 cells.20833159
CCNB1cyclin B1891Breast adenocarcinomaMCF-7----Expression levels of cyclin B1 protein were only slightly decreased following 28-homocastasterone treatment in cancer cell lines.20833159
CCNB1cyclin B1891Breast CarcinomaMDA-MB-468----Expression levels of cyclin B1 protein were only slightly decreased following 28-homocastasterone treatment in cancer cell lines.20833159
CDK2cyclin-dependent kinase 21017Breast adenocarcinomaMCF-7----reduction in CDK2 expression in cell lines was observed after 24 h of 28-homocastasterone treatment.20833159
CDK2cyclin-dependent kinase 21017Breast CarcinomaMDA-MB-468----reduction in CDK2 expression in cell lines was observed after 24 h of 28-homocastasterone treatment.20833159
CDK4cyclin-dependent kinase 41019Breast adenocarcinomaMCF-7----reduction in CDK4 expression in cell lines was observed after 24 h of 28-homocastasterone treatment.20833159
CDK4cyclin-dependent kinase 41019Breast CarcinomaMDA-MB-468----reduction in CDK4 expression in cell lines was observed after 24 h of 28-homocastasterone treatment.20833159
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Breast adenocarcinomaMCF-7----There were increase in p21Waf1/Cip1 expression in MCF-7 cells after 6 h of 28-homoCS treatment.20833159
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Breast adenocarcinomaMCF-7----There were increase in p27Kip1 expression in MCF-7 cells after 6 h of 28-homoCS treatment.20833159
MDM2Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)4193Breast adenocarcinomaMCF-7----MCF-7 cella show decreased expression of MDM-2 after 6 h exposure to 28-homocastasterone20833159
TP53tumor protein p537157Breast adenocarcinomaMCF-7----The MCF-7 cells showed a slight increase in p53 protein expression.20833159

 






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