NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)2064Breast CarcinomaMDA-MB-453----The result of immunoblot analysis using phospho-tyrosine antibody suggested that ON-III inhibited tyrosine kinase phosphorylation of erbB-2 significantly with dose-dependent manner. The expression levels of erbB-2 protein were unaffected following ON-III treatment.19242112
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)2064Breast CarcinomaMDA-MB-453----The result of immunoblot analysis using phospho-tyrosine antibody suggested that ON-III inhibited tyrosine kinase phosphorylation of erbB-2 significantly with dose-dependent manner. The expression levels of erbB-2 protein were unaffected following ON-III treatment.19242112

 






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