NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2L11BCL2-like 11 (apoptosis facilitator)10018Breast CarcinomaMDA-MB-453----Treatment with 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone caused an increase in Bim protein levels.The results also revealed that the levels of all three major splicing isoforms—Bim-extra long (EL), Bim-long (L) and Bim-short (S)—were induced after 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone treatment. And Bim upregulation was involved in 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone-induced apoptosis in MDA-MB-453 cells.19242112

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.