NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone

Targets

Gene Name

Gene ID

Cancer

Cell Lines

IC₅₀

ED₅₀

EC₅₀

GI₅₀

Remark

References

BCL2

B-cell CLL/lymphoma 2

596

Leukemia

K-562

-

-

-

-

The results illustrated that in the same dosage and incubation time, 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone could down-regulate the level of Bcl-2 protein. Resulting in to a lower ratio ofBcl-2/Bax,which might be responsible for the2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone-induced apoptosis in K562 cells.

15978939

BCL2

B-cell CLL/lymphoma 2

596

Leukemia

K-562

-

-

-

-

The results illustrated that in the same dosage and incubation time, 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone could down-regulate the level of Bcl-2 protein. Resulting in to a lower ratio ofBcl-2/Bax,which might be responsible for the2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone-induced apoptosis in K562 cells.

15978939

Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.