NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Breast CarcinomaMDA-MB-453----After treatment of 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone for 1 h, immunoblot analysis revealed the phosphorylation of AKT had dramatic decrease. And results showed that phosphorylation of AKT time-dependently decreased in MDA-MB-453 cells following exposed to 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone.19242112
AKT1v-akt murine thymoma viral oncogene homolog 1207Colon CarcinomaHDMEC----This suggested that ON-III has potent inhibitory effect on activation of Akt in a dose-dependent manner in VEGF-stimulating HDMEC cells after treatment with ON-III for 30 min.15703376
AKT1v-akt murine thymoma viral oncogene homolog 1207Human Carcinoma xenograftsGLC-82----This suggested that ON-III has potent inhibitory effect on activation of Akt in a dose-dependent manner in VEGF-stimulating HDMEC cells after treatment with ON-III for 30 min.15703376
AKT1v-akt murine thymoma viral oncogene homolog 1207Liver CarcinomaBEL-7402----This suggested that ON-III has potent inhibitory effect on activation of Akt in a dose-dependent manner in VEGF-stimulating HDMEC cells after treatment with ON-III for 30 min.15703376

 






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