NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (+)-Gallocatechin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ALPPalkaline phosphatase, placental250Human CarcinomaCeHa----Elevated levels of serum alkaline phosphatase (ALP) in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
ALPPalkaline phosphatase, placental250Dalton'sLymphoma Ascites (DLA)-----Elevated levels of serum alkaline phosphatase (ALP) in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
CDC25Ccell division cycle 25 homolog C (S. pombe)995Human CarcinomaCeHa15 µg/mL.---Emblica officinalis (E. officinalis) polyphenol fraction (EOP) inhibited the activity of cdc25 tyrosine phosphatase, an important enzyme involved in cell cycle regulation. This enzyme is a critical regulator of M phase promoting factor (MPF), which removes inhibitory phosphates in the catalytic domain of p34cdc2 thereby directly controls the entry of cells into M phase.12866570
CDC25Ccell division cycle 25 homolog C (S. pombe)995Dalton'sLymphoma Ascites (DLA)-15 µg/ml---Emblica officinalis (E. officinalis) polyphenol fraction (EOP) inhibited the activity of cdc25 tyrosine phosphatase, an important enzyme involved in cell cycle regulation. This enzyme is a critical regulator of M phase promoting factor (MPF), which removes inhibitory phosphates in the catalytic domain of p34cdc2 thereby directly controls the entry of cells into M phase.12866570
GGT1gamma-glutamyltransferase 12678Human CarcinomaCeHa----Gamma-glutamyl transpeptidase activity was raised to 88.4 ± 16.2 U/l in serum of N- nitrosodiethylamine treated group was reduced to 48.4 ± 14.8 U/l by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
GGT1gamma-glutamyltransferase 12678Dalton'sLymphoma Ascites (DLA)-----Gamma-glutamyl transpeptidase activity was raised to 88.4 ± 16.2 U/l in serum of N- nitrosodiethylamine treated group was reduced to 48.4 ± 14.8 U/l by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
GPTglutamic-pyruvate transaminase (alanine aminotransferase)2875Human CarcinomaCeHa----Elevated levels of serum glutamate pyruvate transaminase (GPT), in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
GPTglutamic-pyruvate transaminase (alanine aminotransferase)2875Dalton'sLymphoma Ascites (DLA)-----Elevated levels of serum glutamate pyruvate transaminase (GPT), in the NDEA administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
GSTM1glutathione S-transferase mu 12944Dalton'sLymphoma Ascites (DLA)-----Elevated levels of liver glutathione S- transferase (GST) level in the N- nitrosodiethylamine administered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
GSTM1glutathione S-transferase mu 12944Human CarcinomaCeHa----Elevated levels of liver glutathione S- transferase (GST) level in the N- nitrosodiethylamineadministered group were significantly reduced by Emblica officinalis (E. officinalis) polyphenol fraction (EOP) treatment.12866570
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Human CarcinomaCeHa----Emblica officinalis (E. officinalis) polyphenol fraction (EOP) was found to inhibit the activity of topoisomerase II in Sacchromyces cerviacae mutant cell cultures. Cancer cells have higher topoisomerase II levels. Therefore, inhibition of this enzyme is a likely target for therapeutic intervention and may suppress cell proliferation.12866570
TOP2Atopoisomerase (DNA) II alpha 170kDa7153Dalton'sLymphoma Ascites (DLA)-----Emblica officinalis (E. officinalis) polyphenol fraction (EOP) was found to inhibit the activity of topoisomerase II in Sacchromyces cerviacae mutant cell cultures. Cancer cells have higher topoisomerase II levels. Therefore, inhibition of this enzyme is a likely target for therapeutic intervention and may suppress cell proliferation.12866570

 






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