NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Morin

ModelsTargetInhibitory ConcRemarkReference
DEN-induced hepatocellular CarcinomaNF-kappaB-p65-During this cancer, inflammation of the liver cause due to up-regulation of NF-kappaB-p65 and COX-2.Oral supplementation of morin (500 ppm in diet) to DEN-induced hepatocellular carcinoma down-regulated the expression of NF-kappaB-p65, thereby preventing inflammation and angiogenesis mediated hepatocellular carcinogenesis.19539802
DEN-induced hepatocellular CarcinomaMMP-9-Matrix metalloproteinase MMP-9 has role in ngiogenesis in DEN induced hepatocellular carcinoma. MMP-9 level was found to be increased in DEN-induced animals when compared to control. MMP-9 level was down-regulated in morin post-treated animals when compared to DEN-induced animals favouring prevention of angiogenesis.19539802
DEN-induced hepatocellular CarcinomaMMP-2-Matrix metalloproteinase MMP-2 has role in ngiogenesis in DEN induced hepatocellular carcinoma. MMP-2 level was found to be increased in DEN-induced animals when compared to control. MMP-2 levels were down-regulated in morin post-treated animals when compared to DEN-induced animals favouring prevention of angiogenesis.19539802
DEN-induced hepatocellular CarcinomaCOX-2-During this cancer, inflammation of the liver cause due to up-regulation of NF-kappaB-p65 and COX-2.Oral supplementation of morin (500 ppm in diet) to DEN-induced hepatocellular carcinoma down-regulated the expression of COX-2, thereby preventing inflammation and angiogenesis mediated hepatocellular carcinogenesis.19539802

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.