NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Curcumin

ModelsTargetInhibitory ConcRemarkReference
TPA induced CD-1 mice--Application of 1, 3,or 10 µmol of curcumin with 5 nmol of TPA twice a week for 20 weeks inhibited the number of skin tumors per mouse by 39,77, or 98%, respectively, and the percentage of animals with tumors was decreased by 21, 66, or 82%, respectively. Additional groups of mice were initiated with DMBA and then treated with acetone or 3 µmol of curcumin twice weekly for 20 weeks. None of these animals developed tumors, indicating that curcumin was not a tumor promoter.3139287

 






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