NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (-)-Epicatechin

ModelsTargetInhibitory ConcRemarkReference
TPA induced SENCAR miceODC(Ornithine Decarboxlase)- It is found that 80 g of (-)-Epicatechin in 2 mg of GTP showed 17% of inibition on TPA-induced Epidermal ODC activity.The topical application of 4 µmol of (-)-Epicatechin in 0.2 ml acetone/animal 30 min prior to the topical application of 5 µg TPA in 0.2 ml acetone resulted in the significant inhibition of TPA-induced epidermal ODC activity.1617628
Carcinogen-treated mouse mammary glands in organ culture.COX-2-Testing of compound was performed in-vivo. Compound is shown have anticancer activity.11962253
Carcinogen-treated mouse mammary glands in organ culture.COX-1IC50= 3.2 µMTesting of compound was performed in-vivo. Compound is shown have anticancer activity.11962253

 






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