Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115927                                                              20     509
XP_006715292                                                           20     509
NP_073728                                                              18    1935
NP_061897                                                              18    1935
XP_006712887                                                           18    1935
XP_005246168                                                           18    1935
XP_006712098                                                           18    1935
XP_006712097                                                           18    1935
NP_775771                                                              17    4312
NP_001008409                                                           17    4312
XP_006720466                                                           17    4312
XP_005254230                                                           17    4312
XP_006720465                                                           17    4312
XP_005254228                                                           17    4312
XP_006712403                                                           17    4312
NP_001157413                                                           16    5631
NP_848654                                                              16    5631
NP_061152                                                              16    7355
NP_891847                                                              16    7355
NP_056288                                                              16    7355
XP_006716112                                                           16    7355
XP_005250550                                                           16    7355
NP_001272456                                                           15    9605
NP_001008504                                                           15    9605
NP_001008503                                                           15    9605
NP_001272457                                                           15    9605
NP_001272452                                                           15    9605
NP_001138751                                                           15    9605
NP_001138754                                                           15    9605
NP_001272455                                                           15    9605
NP_001138757                                                           15    9605
NP_000903                                                              15    9605
NP_001138755                                                           15    9605
NP_001138759                                                           15    9605
NP_001008505                                                           15    9605
NP_001272453                                                           15    9605
NP_001138756                                                           15    9605
NP_001138753                                                           15    9605
NP_001138758                                                           15    9605
NP_000905                                                              15    9605
NP_001269833                                                           15    9605
NP_001138752                                                           15    9605
NP_000902                                                              15    9605
XP_006723788                                                           15    9605
XP_005260366                                                           15    9605
XP_005251309                                                           15    9605
XP_006715559                                                           15    9605
>NP_115927
          Length = 1321

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   YQLIMSVF 9
           YQLIMSVF
Sbjct: 286 YQLIMSVF 293
>XP_006715292
          Length = 759

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   YQLIMSVF 9
           YQLIMSVF
Sbjct: 273 YQLIMSVF 280
>NP_073728
          Length = 1255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YYQLIMS 7
           YYQL+MS
Sbjct: 154 YYQLLMS 160
>NP_061897
          Length = 2071

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    YQLIMSVF 9
            YQL++SVF
Sbjct: 1905 YQLLLSVF 1912
>XP_006712887
          Length = 1255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YYQLIMS 7
           YYQL+MS
Sbjct: 154 YYQLLMS 160
>XP_005246168
          Length = 1255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YYQLIMS 7
           YYQL+MS
Sbjct: 154 YYQLLMS 160
>XP_006712098
          Length = 2059

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    YQLIMSVF 9
            YQL++SVF
Sbjct: 1893 YQLLLSVF 1900
>XP_006712097
          Length = 2070

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    YQLIMSVF 9
            YQL++SVF
Sbjct: 1904 YQLLLSVF 1911
>NP_775771
          Length = 1244

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQLIMSVF 9
           YQL+ SVF
Sbjct: 273 YQLLTSVF 280
>NP_001008409
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQLIMSVF 9
           Y L+MSVF
Sbjct: 230 YVLVMSVF 237
>XP_006720466
          Length = 1175

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQLIMSVF 9
           YQL+ SVF
Sbjct: 204 YQLLTSVF 211
>XP_005254230
          Length = 1175

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQLIMSVF 9
           YQL+ SVF
Sbjct: 204 YQLLTSVF 211
>XP_006720465
          Length = 1239

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQLIMSVF 9
           YQL+ SVF
Sbjct: 268 YQLLTSVF 275
>XP_005254228
          Length = 1250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YQLIMSVF 9
           YQL+ SVF
Sbjct: 279 YQLLTSVF 286
>XP_006712403
          Length = 211

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YYQLIMSVF 9
          Y+QL +S+F
Sbjct: 10 YFQLFVSLF 18
>NP_001157413
          Length = 1257

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YYQLIMS 7
           YY L+MS
Sbjct: 616 YYSLVMS 622
>NP_848654
          Length = 812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   YYQLIMS 7
           YY L+MS
Sbjct: 171 YYSLVMS 177
>NP_061152
          Length = 1858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YYQLIMSVF 9
           +YQL+ SV+
Sbjct: 876 FYQLLDSVY 884
>NP_891847
          Length = 1858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YYQLIMSVF 9
           +YQL+ SV+
Sbjct: 876 FYQLLDSVY 884
>NP_056288
          Length = 2046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YQLIMSVF 9
            YQL+ S+F
Sbjct: 1879 YQLLHSIF 1886
>XP_006716112
          Length = 1816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YYQLIMSVF 9
           +YQL+ SV+
Sbjct: 876 FYQLLDSVY 884
>XP_005250550
          Length = 1858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YYQLIMSVF 9
           +YQL+ SV+
Sbjct: 876 FYQLLDSVY 884
>NP_001272456
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YYQLIMSVF 9
          YY +  S+F
Sbjct: 50 YYNMFTSIF 58
>NP_001008504
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_001008503
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_001272457
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YYQLIMSVF 9
          YY +  S+F
Sbjct: 50 YYNMFTSIF 58
>NP_001272452
          Length = 414

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_001138751
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 243 YYNMFTSIF 251
>NP_001138754
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_001272455
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YYQLIMSVF 9
          YY +  S+F
Sbjct: 50 YYNMFTSIF 58
>NP_001138757
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_000903
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 139 YYNMFTSIF 147
>NP_001138755
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_001138759
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YYQLIMSVF 9
          YY +  S+F
Sbjct: 50 YYNMFTSIF 58
>NP_001008505
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_001272453
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 243 YYNMFTSIF 251
>NP_001138756
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_001138753
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YYQLIMSVF 9
          YY +  S+F
Sbjct: 69 YYNMFTSIF 77
>NP_001138758
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_000905
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 150 YYNMFTSIF 158
>NP_001269833
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YYQLIMSVF 9
          YY +  S+F
Sbjct: 50 YYNMFTSIF 58
>NP_001138752
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  YYQLIMSVF 9
          YY +  S+F
Sbjct: 50 YYNMFTSIF 58
>NP_000902
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 129 YYNMFTSIF 137
>XP_006723788
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YQLIMSVF 9
           Y L+MS+F
Sbjct: 180 YVLVMSMF 187
>XP_005260366
          Length = 279

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YQLIMSVF 9
           Y L+MS+F
Sbjct: 212 YVLVMSMF 219
>XP_005251309
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 125 YYNMFTSIF 133
>XP_006715559
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1   YYQLIMSVF 9
           YY +  S+F
Sbjct: 243 YYNMFTSIF 251
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.347    0.152    0.449 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 338,313
Number of extensions: 459
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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