Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              22     103
NP_001263689                                                           22     103
NP_001119584                                                           22     103
NP_001119586                                                           22     103
NP_001263625                                                           22     103
NP_001119590                                                           22     103
NP_001263690                                                           22     103
NP_001119585                                                           22     103
NP_001263624                                                           22     103
NP_001243624                                                           17    3301
XP_006714533                                                           17    3301
XP_005248344                                                           17    3301
NP_277019                                                              17    3301
NP_071433                                                              17    3301
NP_066553                                                              17    3301
NP_036308                                                              17    3301
NP_001619                                                              16    5631
NP_115971                                                              16    5631
XP_005250291                                                           16    5631
NP_001007279                                                           16    7355
NP_434698                                                              16    7355
NP_998755                                                              16    7355
NP_005789                                                              16    7355
NP_055855                                                              15    9605
NP_003165                                                              15    9605
NP_068506                                                              15    9605
NP_001098998                                                           15    9605
NP_945346                                                              15    9605
NP_003624                                                              15    9605
NP_001243503                                                           15    9605
NP_001243505                                                           15    9605
NP_004720                                                              15    9605
NP_001164607                                                           15    9605
NP_001164606                                                           15    9605
NP_001243504                                                           15    9605
NP_001156896                                                           15    9605
NP_443152                                                              15    9605
XP_006717559                                                           15    9605
XP_006717558                                                           15    9605
XP_006717557                                                           15    9605
XP_006717556                                                           15    9605
XP_005252630                                                           15    9605
XP_005252629                                                           15    9605
XP_005252628                                                           15    9605
XP_005252627                                                           15    9605
XP_005252626                                                           15    9605
XP_005252625                                                           15    9605
XP_005252624                                                           15    9605
XP_005252623                                                           15    9605
XP_005252622                                                           15    9605
XP_006717555                                                           15    9605
XP_005252621                                                           15    9605
XP_006712426                                                           15    9605
XP_006712425                                                           15    9605
XP_006712424                                                           15    9605
XP_006711992                                                           15    9605
NP_612209                                                              15    9605
NP_002931                                                              15    9605
NP_001035809                                                           15    9605
>NP_000537
          Length = 393

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YSPAVNKMF 9
           YSPA+NKMF
Sbjct: 126 YSPALNKMF 134
>NP_001263689
          Length = 354

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  YSPAVNKMF 9
          YSPA+NKMF
Sbjct: 87 YSPALNKMF 95
>NP_001119584
          Length = 393

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YSPAVNKMF 9
           YSPA+NKMF
Sbjct: 126 YSPALNKMF 134
>NP_001119586
          Length = 341

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YSPAVNKMF 9
           YSPA+NKMF
Sbjct: 126 YSPALNKMF 134
>NP_001263625
          Length = 302

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  YSPAVNKMF 9
          YSPA+NKMF
Sbjct: 87 YSPALNKMF 95
>NP_001119590
          Length = 354

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  YSPAVNKMF 9
          YSPA+NKMF
Sbjct: 87 YSPALNKMF 95
>NP_001263690
          Length = 354

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  YSPAVNKMF 9
          YSPA+NKMF
Sbjct: 87 YSPALNKMF 95
>NP_001119585
          Length = 346

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YSPAVNKMF 9
           YSPA+NKMF
Sbjct: 126 YSPALNKMF 134
>NP_001263624
          Length = 307

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  YSPAVNKMF 9
          YSPA+NKMF
Sbjct: 87 YSPALNKMF 95
>NP_001243624
          Length = 1177

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YSPAVNKMF 9
           YSP +N+M+
Sbjct: 520 YSPTLNEMW 528
>XP_006714533
          Length = 243

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YSPAVNKMF 9
           ++ AVNKMF
Sbjct: 107 HTSAVNKMF 115
>XP_005248344
          Length = 305

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YSPAVNKMF 9
           ++ AVNKMF
Sbjct: 251 HTSAVNKMF 259
>NP_277019
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YSPAVNKMF 9
           ++ AVNKMF
Sbjct: 251 HTSAVNKMF 259
>NP_071433
          Length = 196

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  SPAVNKM 8
          +PAVNKM
Sbjct: 75 TPAVNKM 81
>NP_066553
          Length = 473

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  YSPAVNK 7
          Y PAVNK
Sbjct: 86 YPPAVNK 92
>NP_036308
          Length = 387

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YSPAVNKMF 9
           ++ AVNKMF
Sbjct: 251 HTSAVNKMF 259
>NP_001619
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YSPAVNKM 8
           Y PAVN++
Sbjct: 178 YKPAVNQI 185
>NP_115971
          Length = 1604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SPAVNKMF 9
            SP+ N+MF
Sbjct: 1017 SPSTNEMF 1024
>XP_005250291
          Length = 172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YSPAVNKM 8
          Y PAVN++
Sbjct: 34 YKPAVNQI 41
>NP_001007279
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   YSPAVNKM 8
           Y P +NK+
Sbjct: 218 YDPEINKL 225
>NP_434698
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   YSPAVNKM 8
           Y P +NK+
Sbjct: 215 YDPEINKL 222
>NP_998755
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   YSPAVNKM 8
           Y P +NK+
Sbjct: 215 YDPEINKL 222
>NP_005789
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   YSPAVNKM 8
           Y P +NK+
Sbjct: 215 YDPEINKL 222
>NP_055855
          Length = 2098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    YSPAVNKMF 9
            +SP +NK F
Sbjct: 1087 WSPLLNKEF 1095
>NP_003165
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 445 FSPAVN 450
>NP_068506
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 871 FSPAVN 876
>NP_001098998
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SPAVNKM 8
          +P VNKM
Sbjct: 93 APCVNKM 99
>NP_945346
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SPAVNKM 8
          +P VNKM
Sbjct: 93 APCVNKM 99
>NP_003624
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 1   YSPAVNK 7
           Y P +NK
Sbjct: 417 YDPTINK 423
>NP_001243503
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 1   YSPAVNK 7
           Y P +NK
Sbjct: 417 YDPTINK 423
>NP_001243505
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 1   YSPAVNK 7
           Y P +NK
Sbjct: 344 YDPTINK 350
>NP_004720
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YSPAVNKMF 9
           Y PA +K+F
Sbjct: 513 YRPAEDKIF 521
>NP_001164607
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YSPAVNKMF 9
           Y PA +K+F
Sbjct: 513 YRPAEDKIF 521
>NP_001164606
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YSPAVNKMF 9
           Y PA +K+F
Sbjct: 513 YRPAEDKIF 521
>NP_001243504
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 1   YSPAVNK 7
           Y P +NK
Sbjct: 417 YDPTINK 423
>NP_001156896
          Length = 57

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3 PAVNKMF 9
         PAV++MF
Sbjct: 3 PAVDEMF 9
>NP_443152
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 172 FSPAVN 177
>XP_006717559
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 523 FSPAVN 528
>XP_006717558
          Length = 1908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 523 FSPAVN 528
>XP_006717557
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 555 FSPAVN 560
>XP_006717556
          Length = 2024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 639 FSPAVN 644
>XP_005252630
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 871 FSPAVN 876
>XP_005252629
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 871 FSPAVN 876
>XP_005252628
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 871 FSPAVN 876
>XP_005252627
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 871 FSPAVN 876
>XP_005252626
          Length = 2260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 917 FSPAVN 922
>XP_005252625
          Length = 2277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 892 FSPAVN 897
>XP_005252624
          Length = 2292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 949 FSPAVN 954
>XP_005252623
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 917 FSPAVN 922
>XP_005252622
          Length = 2308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 949 FSPAVN 954
>XP_006717555
          Length = 2328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 943 FSPAVN 948
>XP_005252621
          Length = 2334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 949 FSPAVN 954
>XP_006712426
          Length = 1237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YSPAVNKMF 9
           +SP +NK F
Sbjct: 393 WSPLLNKEF 401
>XP_006712425
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YSPAVNKMF 9
           +SP +NK F
Sbjct: 393 WSPLLNKEF 401
>XP_006712424
          Length = 1376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YSPAVNKMF 9
           +SP +NK F
Sbjct: 393 WSPLLNKEF 401
>XP_006711992
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YSPAVN 6
           +SPAVN
Sbjct: 172 FSPAVN 177
>NP_612209
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  PAVNKMF 9
          PAV++MF
Sbjct: 24 PAVDEMF 30
>NP_002931
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   YSPAVNKM 8
           Y P +NK+
Sbjct: 573 YRPRINKL 580
>NP_001035809
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   YSPAVNKM 8
           Y P +NK+
Sbjct: 573 YRPRINKL 580
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.131    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 640,272
Number of extensions: 801
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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