Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000542                                                              19     869
NP_937799                                                              19     869
NP_001006635                                                           17    2528
NP_060524                                                              17    2528
XP_006721123                                                           17    2528
XP_005255471                                                           17    2528
XP_006721121                                                           17    2528
XP_005255470                                                           17    2528
XP_006721120                                                           17    2528
NP_001229813                                                           17    4312
NP_001274533                                                           17    4312
NP_001274532                                                           17    4312
NP_003434                                                              17    4312
XP_005246044                                                           17    4312
XP_005246043                                                           17    4312
NP_066264                                                              16    5631
NP_001136401                                                           16    5631
NP_065574                                                              16    5631
NP_001136405                                                           16    5631
NP_001136406                                                           16    5631
NP_066266                                                              16    5631
NP_066265                                                              16    5631
NP_001230280                                                           16    5631
NP_057202                                                              16    5631
NP_055736                                                              16    5631
NP_001008701                                                           16    5631
XP_005259876                                                           16    5631
XP_006722752                                                           16    5631
XP_005259875                                                           16    5631
XP_006722751                                                           16    5631
XP_005250068                                                           16    5631
XP_005250067                                                           16    5631
NP_005199                                                              16    7355
NP_004704                                                              16    7355
NP_114141                                                              16    7355
XP_006721769                                                           16    7355
XP_005268258                                                           16    7355
XP_005268257                                                           16    7355
XP_005268256                                                           16    7355
NP_060391                                                              15    9605
NP_001153517                                                           15    9605
NP_005260                                                              15    9605
NP_001161081                                                           15    9605
NP_006495                                                              15    9605
NP_002204                                                              15    9605
NP_001131022                                                           15    9605
NP_001157945                                                           15    9605
NP_060207                                                              15    9605
NP_001020119                                                           15    9605
XP_005268856                                                           15    9605
XP_006717995                                                           15    9605
XP_005252749                                                           15    9605
XP_005252748                                                           15    9605
XP_006713693                                                           15    9605
XP_005247493                                                           15    9605
XP_006712913                                                           15    9605
XP_005246199                                                           15    9605
XP_005246198                                                           15    9605
XP_005246197                                                           15    9605
XP_005246196                                                           15    9605
XP_005246195                                                           15    9605
XP_005246194                                                           15    9605
XP_006710770                                                           15    9605
NP_569119                                                              15    9605
NP_001131023                                                           15    9605
>NP_000542
          Length = 213

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YRRLDNVRS 9
           YRRLD VRS
Sbjct: 175 YRRLDIVRS 183
>NP_937799
          Length = 172

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YRRLDNVRS 9
           YRRLD VRS
Sbjct: 134 YRRLDIVRS 142
>NP_001006635
          Length = 881

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RRLDNVRS 9
          RRLD VRS
Sbjct: 34 RRLDTVRS 41
>NP_060524
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RRLDNVRS 9
          RRLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_006721123
          Length = 775

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RRLDNVRS 9
          RRLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_005255471
          Length = 840

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RRLDNVRS 9
          RRLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_006721121
          Length = 853

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RRLDNVRS 9
          RRLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_005255470
          Length = 853

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RRLDNVRS 9
          RRLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_006721120
          Length = 880

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RRLDNVRS 9
          RRLD VRS
Sbjct: 33 RRLDTVRS 40
>NP_001229813
          Length = 721

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRRLDNVRS 9
           + R+DN+RS
Sbjct: 541 FNRVDNLRS 549
>NP_001274533
          Length = 727

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRRLDNVRS 9
           + R+DN+RS
Sbjct: 547 FNRVDNLRS 555
>NP_001274532
          Length = 810

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRRLDNVRS 9
           + R+DN+RS
Sbjct: 623 FNRVDNLRS 631
>NP_003434
          Length = 803

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRRLDNVRS 9
           + R+DN+RS
Sbjct: 623 FNRVDNLRS 631
>XP_005246044
          Length = 734

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRRLDNVRS 9
           + R+DN+RS
Sbjct: 547 FNRVDNLRS 555
>XP_005246043
          Length = 747

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YRRLDNVRS 9
           + R+DN+RS
Sbjct: 560 FNRVDNLRS 568
>NP_066264
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           R+DN+RS
Sbjct: 448 RVDNIRS 454
>NP_001136401
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           R+DN+RS
Sbjct: 448 RVDNIRS 454
>NP_065574
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           R+DN+RS
Sbjct: 566 RVDNIRS 572
>NP_001136405
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           R+DN+RS
Sbjct: 484 RVDNIRS 490
>NP_001136406
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           R+DN+RS
Sbjct: 448 RVDNIRS 454
>NP_066266
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           R+DN+RS
Sbjct: 448 RVDNIRS 454
>NP_066265
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           R+DN+RS
Sbjct: 448 RVDNIRS 454
>NP_001230280
          Length = 639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           RRL+N+R
Sbjct: 455 RRLENIR 461
>NP_057202
          Length = 625

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           RRL+N+R
Sbjct: 455 RRLENIR 461
>NP_055736
          Length = 1469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RLDNVRS 9
            RLDN++S
Sbjct: 1037 RLDNIKS 1043
>NP_001008701
          Length = 1474

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RLDNVRS 9
            RLDN++S
Sbjct: 1042 RLDNIKS 1048
>XP_005259876
          Length = 1498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RLDNVRS 9
            RLDN++S
Sbjct: 1042 RLDNIKS 1048
>XP_006722752
          Length = 1462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RLDNVRS 9
            RLDN++S
Sbjct: 1006 RLDNIKS 1012
>XP_005259875
          Length = 1493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RLDNVRS 9
            RLDN++S
Sbjct: 1037 RLDNIKS 1043
>XP_006722751
          Length = 1498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RLDNVRS 9
            RLDN++S
Sbjct: 1042 RLDNIKS 1048
>XP_005250068
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           RRL+N+R
Sbjct: 431 RRLENIR 437
>XP_005250067
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           RRL+N+R
Sbjct: 454 RRLENIR 460
>NP_005199
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RRLDNVRS 9
          R  DNVRS
Sbjct: 58 RSFDNVRS 65
>NP_004704
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           ++LDNVR
Sbjct: 321 KKLDNVR 327
>NP_114141
          Length = 5635

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YRRLDNV 7
           +RRLDN+
Sbjct: 826 WRRLDNM 832
>XP_006721769
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  RRLDNVRS 9
          R  DNVRS
Sbjct: 72 RSFDNVRS 79
>XP_005268258
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RRLDNVR 8
          ++LDNVR
Sbjct: 92 KKLDNVR 98
>XP_005268257
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           ++LDNVR
Sbjct: 107 KKLDNVR 113
>XP_005268256
          Length = 1055

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           ++LDNVR
Sbjct: 321 KKLDNVR 327
>NP_060391
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   YRRLDNV 7
           YR +DN+
Sbjct: 220 YRHVDNI 226
>NP_001153517
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           RRL+N+R
Sbjct: 368 RRLENLR 374
>NP_005260
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           RRL+N+R
Sbjct: 496 RRLENLR 502
>NP_001161081
          Length = 1065

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           RRL+N+R
Sbjct: 455 RRLENLR 461
>NP_006495
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YRRLDNVR 8
           +R+L NVR
Sbjct: 430 FRKLTNVR 437
>NP_002204
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LDNVRS 9
           LDN+RS
Sbjct: 154 LDNIRS 159
>NP_001131022
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 519 KLDNLRS 525
>NP_001157945
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YRRLDN 6
           Y RLDN
Sbjct: 154 YERLDN 159
>NP_060207
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YRRLDN 6
           Y RLDN
Sbjct: 154 YERLDN 159
>NP_001020119
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YRRLDN 6
           Y RLDN
Sbjct: 154 YERLDN 159
>XP_005268856
          Length = 978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRLDNVR 8
           RRL+N+R
Sbjct: 368 RRLENLR 374
>XP_006717995
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YRRLDNVR 8
           +R+L NVR
Sbjct: 429 FRKLTNVR 436
>XP_005252749
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YRRLDNVR 8
           +R+L NVR
Sbjct: 430 FRKLTNVR 437
>XP_005252748
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YRRLDNVR 8
           +R+L NVR
Sbjct: 430 FRKLTNVR 437
>XP_006713693
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LDNVRS 9
           LDN+RS
Sbjct: 154 LDNIRS 159
>XP_005247493
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LDNVRS 9
           LDN+RS
Sbjct: 154 LDNIRS 159
>XP_006712913
          Length = 648

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 527 KLDNLRS 533
>XP_005246199
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 283 KLDNLRS 289
>XP_005246198
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 307 KLDNLRS 313
>XP_005246197
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 454 KLDNLRS 460
>XP_005246196
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 478 KLDNLRS 484
>XP_005246195
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 540 KLDNLRS 546
>XP_005246194
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 540 KLDNLRS 546
>XP_006710770
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   YRRLDN 6
           Y RLDN
Sbjct: 136 YERLDN 141
>NP_569119
          Length = 642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YRRLDNVR 8
           +R+L NVR
Sbjct: 372 FRKLTNVR 379
>NP_001131023
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDNVRS 9
           +LDN+RS
Sbjct: 273 KLDNLRS 279
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.141    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,002
Number of extensions: 623
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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