Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              19     665
XP_006717989                                                           19     665
NP_036434                                                              17    4312
XP_005270731                                                           17    4312
XP_005270730                                                           17    4312
XP_006710560                                                           17    4312
XP_006710559                                                           17    4312
XP_006710558                                                           17    4312
XP_006710557                                                           17    4312
XP_006710556                                                           17    4312
XP_006710555                                                           17    4312
XP_005270727                                                           17    4312
XP_006710554                                                           17    4312
XP_005270725                                                           17    4312
XP_005270724                                                           17    4312
XP_006710553                                                           17    4312
XP_005270723                                                           17    4312
XP_006710552                                                           17    4312
XP_006710551                                                           17    4312
XP_006710550                                                           17    4312
XP_006710549                                                           17    4312
XP_006710548                                                           17    4312
NP_001004693                                                           17    4312
NP_002261                                                              16    5631
NP_694858                                                              16    5631
XP_005248557                                                           16    5631
XP_005248558                                                           16    5631
NP_776169                                                              16    7355
NP_525022                                                              15    9605
NP_115946                                                              15    9605
NP_001277255                                                           15    9605
NP_001277254                                                           15    9605
NP_065849                                                              15    9605
XP_005256994                                                           15    9605
XP_005256993                                                           15    9605
XP_005256992                                                           15    9605
XP_006721697                                                           15    9605
XP_006721696                                                           15    9605
XP_005256991                                                           15    9605
XP_005250953                                                           15    9605
XP_005250952                                                           15    9605
XP_005250951                                                           15    9605
XP_005273127                                                           15    9605
NP_861452                                                              15    9605
>NP_000305
          Length = 403

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   YLVLTLTK 8
           YLVLTLTK
Sbjct: 315 YLVLTLTK 322
>XP_006717989
          Length = 388

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   YLVLTLTK 8
           YLVLTLTK
Sbjct: 300 YLVLTLTK 307
>NP_036434
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 995  FLVITLCKM 1003
>XP_005270731
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 995  FLVITLCKM 1003
>XP_005270730
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 995  FLVITLCKM 1003
>XP_006710560
          Length = 1181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710559
          Length = 1188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710558
          Length = 1191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710557
          Length = 1191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710556
          Length = 1195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710555
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 995  FLVITLCKM 1003
>XP_005270727
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 995  FLVITLCKM 1003
>XP_006710554
          Length = 1421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_005270725
          Length = 1446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 995  FLVITLCKM 1003
>XP_005270724
          Length = 1446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 995  FLVITLCKM 1003
>XP_006710553
          Length = 1451

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1000 FLVITLCKM 1008
>XP_005270723
          Length = 1459

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1008 FLVITLCKM 1016
>XP_006710552
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710551
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710550
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710549
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>XP_006710548
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    YLVLTLTKM 9
            +LV+TL KM
Sbjct: 1013 FLVITLCKM 1021
>NP_001004693
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YLVLTLTKM 9
           Y++LT+ KM
Sbjct: 220 YIILTIHKM 228
>NP_002261
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YLVLTLTKM 9
          YL+  LTK+
Sbjct: 57 YLIFVLTKL 65
>NP_694858
          Length = 890

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YLVLTLTKM 9
          YL+  LTK+
Sbjct: 49 YLIFVLTKL 57
>XP_005248557
          Length = 890

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YLVLTLTKM 9
          YL+  LTK+
Sbjct: 49 YLIFVLTKL 57
>XP_005248558
          Length = 866

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  YLVLTLTKM 9
          YL+  LTK+
Sbjct: 57 YLIFVLTKL 65
>NP_776169
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   YLVLTLT 7
           YLVLTL+
Sbjct: 334 YLVLTLS 340
>NP_525022
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 413 YLVLTL 418
>NP_115946
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLTLTK 8
           YL+LTL +
Sbjct: 760 YLILTLLR 767
>NP_001277255
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLTLTK 8
           YL+LTL +
Sbjct: 305 YLILTLLR 312
>NP_001277254
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLTLTK 8
           YL+LTL +
Sbjct: 760 YLILTLLR 767
>NP_065849
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLVLTLTK 8
           YL+LTL +
Sbjct: 803 YLILTLLR 810
>XP_005256994
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 421 YLVLTL 426
>XP_005256993
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 332 YLVLTL 337
>XP_005256992
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 332 YLVLTL 337
>XP_006721697
          Length = 1625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 421 YLVLTL 426
>XP_006721696
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 421 YLVLTL 426
>XP_005256991
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   YLVLTL 6
           YLVLTL
Sbjct: 421 YLVLTL 426
>XP_005250953
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLVLTLT 7
           YLV TLT
Sbjct: 102 YLVCTLT 108
>XP_005250952
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLVLTLT 7
           YLV TLT
Sbjct: 248 YLVCTLT 254
>XP_005250951
          Length = 660

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLVLTLT 7
           YLV TLT
Sbjct: 290 YLVCTLT 296
>XP_005273127
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  VLTLTKM 9
          VLTLTK+
Sbjct: 18 VLTLTKV 24
>NP_861452
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLVLTLT 7
           YLV TLT
Sbjct: 353 YLVCTLT 359
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.142    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 311,648
Number of extensions: 328
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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