Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005350                                                              21     229
NP_001746                                                              17    4312
NP_074036                                                              17    4312
NP_291027                                                              17    4312
NP_001008409                                                           17    4312
NP_001561                                                              17    4312
XP_006723789                                                           17    4312
XP_006723788                                                           17    4312
XP_005260366                                                           17    4312
XP_006723787                                                           17    4312
XP_006723786                                                           17    4312
XP_006723785                                                           17    4312
XP_006723784                                                           17    4312
XP_006723783                                                           17    4312
XP_006723782                                                           17    4312
XP_006723781                                                           17    4312
XP_006723780                                                           17    4312
XP_006723779                                                           17    4312
XP_005256269                                                           17    4312
NP_000543                                                              16    5631
NP_001073964                                                           16    5631
NP_057726                                                              16    5631
NP_004319                                                              16    5631
NP_001073335                                                           16    5631
NP_001244273                                                           16    5631
NP_001244271                                                           16    5631
NP_001244272                                                           16    5631
XP_005254495                                                           16    5631
XP_006715861                                                           16    5631
XP_006715860                                                           16    5631
XP_005246804                                                           16    5631
XP_006712741                                                           16    5631
NP_056171                                                              16    7355
NP_874365                                                              16    7355
NP_001025042                                                           16    7355
NP_001193928                                                           16    7355
NP_061914                                                              16    7355
NP_001107656                                                           16    7355
NP_736610                                                              16    7355
NP_001012999                                                           16    7355
NP_938072                                                              16    7355
NP_036267                                                              16    7355
NP_009105                                                              16    7355
XP_006723626                                                           16    7355
XP_006719367                                                           16    7355
XP_006719366                                                           16    7355
XP_006719365                                                           16    7355
XP_005253886                                                           16    7355
XP_006719269                                                           16    7355
XP_005267094                                                           16    7355
XP_005267092                                                           16    7355
NP_056134                                                              16    7355
NP_001139114                                                           15    9605
NP_055502                                                              15    9605
NP_001156757                                                           15    9605
NP_001156758                                                           15    9605
NP_005234                                                              15    9605
NP_053733                                                              15    9605
XP_005261447                                                           15    9605
XP_006724230                                                           15    9605
XP_006724229                                                           15    9605
XP_005261446                                                           15    9605
XP_006713894                                                           15    9605
XP_006713893                                                           15    9605
XP_006713892                                                           15    9605
XP_005269431                                                           15    9605
XP_006713891                                                           15    9605
XP_006713890                                                           15    9605
NP_659493                                                              15    9605
>NP_005350
          Length = 552

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YLEREAGRA 9
           YL+REAGRA
Sbjct: 413 YLDREAGRA 421
>NP_001746
          Length = 182

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LEREAGR 8
          LEREAG+
Sbjct: 88 LEREAGK 94
>NP_074036
          Length = 187

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LEREAGR 8
          LEREAG+
Sbjct: 88 LEREAGK 94
>NP_291027
          Length = 630

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL+ EAGR
Sbjct: 582 YLDYEAGR 589
>NP_001008409
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 124 LEREAGK 130
>NP_001561
          Length = 625

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YLE+ AGR
Sbjct: 458 YLEKGAGR 465
>XP_006723789
          Length = 239

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 106 LEREAGK 112
>XP_006723788
          Length = 247

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LEREAGR 8
          LEREAG+
Sbjct: 74 LEREAGK 80
>XP_005260366
          Length = 279

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 106 LEREAGK 112
>XP_006723787
          Length = 347

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LEREAGR 8
          LEREAG+
Sbjct: 74 LEREAGK 80
>XP_006723786
          Length = 355

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LEREAGR 8
          LEREAG+
Sbjct: 74 LEREAGK 80
>XP_006723785
          Length = 379

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 106 LEREAGK 112
>XP_006723784
          Length = 379

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 106 LEREAGK 112
>XP_006723783
          Length = 410

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 106 LEREAGK 112
>XP_006723782
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 106 LEREAGK 112
>XP_006723781
          Length = 485

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LEREAGR 8
          LEREAG+
Sbjct: 74 LEREAGK 80
>XP_006723780
          Length = 517

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 106 LEREAGK 112
>XP_006723779
          Length = 540

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LEREAGR 8
           LEREAG+
Sbjct: 106 LEREAGK 112
>XP_005256269
          Length = 148

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LEREAGR 8
          LEREAG+
Sbjct: 88 LEREAGK 94
>NP_000543
          Length = 2813

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   YLEREAG 7
           YLE EAG
Sbjct: 119 YLETEAG 125
>NP_001073964
          Length = 2968

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EREAGR 8
           EREAGR
Sbjct: 401 EREAGR 406
>NP_057726
          Length = 3674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LEREAGR 8
            LERE GR
Sbjct: 2423 LEREVGR 2429
>NP_004319
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YLEREAGR 8
          YL+ E+GR
Sbjct: 83 YLQHESGR 90
>NP_001073335
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YLEREAGR 8
          YL+ E+GR
Sbjct: 83 YLQHESGR 90
>NP_001244273
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YLEREAGR 8
          YL+ E+GR
Sbjct: 83 YLQHESGR 90
>NP_001244271
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YLEREAGR 8
          YL+ E+GR
Sbjct: 83 YLQHESGR 90
>NP_001244272
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YLEREAGR 8
          YL+ E+GR
Sbjct: 83 YLQHESGR 90
>XP_005254495
          Length = 3694

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    LEREAGR 8
            LERE GR
Sbjct: 2443 LEREVGR 2449
>XP_006715861
          Length = 2189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EREAGR 8
           EREAGR
Sbjct: 401 EREAGR 406
>XP_006715860
          Length = 2968

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   EREAGR 8
           EREAGR
Sbjct: 401 EREAGR 406
>XP_005246804
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YLEREAGR 8
          YL+ E+GR
Sbjct: 83 YLQHESGR 90
>XP_006712741
          Length = 419

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  YLEREAGR 8
          YL+ E+GR
Sbjct: 83 YLQHESGR 90
>NP_056171
          Length = 1630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEREAG 7
           LEREAG
Sbjct: 946 LEREAG 951
>NP_874365
          Length = 1655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEREAG 7
           LEREAG
Sbjct: 946 LEREAG 951
>NP_001025042
          Length = 234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   REAGRA 9
           REAGRA
Sbjct: 168 REAGRA 173
>NP_001193928
          Length = 2069

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YLE +AG+
Sbjct: 860 YLETQAGK 867
>NP_061914
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YLEREAG 7
          +LER+AG
Sbjct: 46 FLERQAG 52
>NP_001107656
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YLEREAG 7
          +LER+AG
Sbjct: 46 FLERQAG 52
>NP_736610
          Length = 1409

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEREAG 7
           LEREAG
Sbjct: 709 LEREAG 714
>NP_001012999
          Length = 967

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           +LE+E GR
Sbjct: 122 HLEKETGR 129
>NP_938072
          Length = 1285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEREAG 7
           LEREAG
Sbjct: 585 LEREAG 590
>NP_036267
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  REAGRA 9
          REAGRA
Sbjct: 9  REAGRA 14
>NP_009105
          Length = 2027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YLE +AG+
Sbjct: 818 YLETQAGK 825
>XP_006723626
          Length = 266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   REAGRA 9
           REAGRA
Sbjct: 168 REAGRA 173
>XP_006719367
          Length = 881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEREAG 7
           LEREAG
Sbjct: 728 LEREAG 733
>XP_006719366
          Length = 1418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEREAG 7
           LEREAG
Sbjct: 718 LEREAG 723
>XP_006719365
          Length = 1428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEREAG 7
           LEREAG
Sbjct: 728 LEREAG 733
>XP_005253886
          Length = 1545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YLE +AG+
Sbjct: 352 YLETQAGK 359
>XP_006719269
          Length = 2054

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YLE +AG+
Sbjct: 860 YLETQAGK 867
>XP_005267094
          Length = 235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YLEREAG 7
          +LER+AG
Sbjct: 46 FLERQAG 52
>XP_005267092
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  YLEREAG 7
          +LER+AG
Sbjct: 46 FLERQAG 52
>NP_056134
          Length = 1419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LEREAG 7
           LEREAG
Sbjct: 719 LEREAG 724
>NP_001139114
          Length = 927

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YLEREAGR 8
           Y+E E GR
Sbjct: 404 YMEYEGGR 411
>NP_055502
          Length = 972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YLEREAGR 8
           Y+E E GR
Sbjct: 449 YMEYEGGR 456
>NP_001156757
          Length = 655

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL++E G+
Sbjct: 400 YLDKETGK 407
>NP_001156758
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL++E G+
Sbjct: 345 YLDKETGK 352
>NP_005234
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL++E G+
Sbjct: 401 YLDKETGK 408
>NP_053733
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL++E G+
Sbjct: 406 YLDKETGK 413
>XP_005261447
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL++E G+
Sbjct: 345 YLDKETGK 352
>XP_006724230
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL++E G+
Sbjct: 401 YLDKETGK 408
>XP_006724229
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL++E G+
Sbjct: 401 YLDKETGK 408
>XP_005261446
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YLEREAGR 8
           YL++E G+
Sbjct: 401 YLDKETGK 408
>XP_006713894
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YLEREAGR 8
           Y+E E GR
Sbjct: 297 YMEYEGGR 304
>XP_006713893
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YLEREAGR 8
           Y+E E GR
Sbjct: 297 YMEYEGGR 304
>XP_006713892
          Length = 952

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YLEREAGR 8
           Y+E E GR
Sbjct: 404 YMEYEGGR 411
>XP_005269431
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YLEREAGR 8
           Y+E E GR
Sbjct: 464 YMEYEGGR 471
>XP_006713891
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YLEREAGR 8
           Y+E E GR
Sbjct: 449 YMEYEGGR 456
>XP_006713890
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YLEREAGR 8
           Y+E E GR
Sbjct: 464 YMEYEGGR 471
>NP_659493
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LEREAGRA 9
           LE+E+GR+
Sbjct: 107 LEQESGRS 114
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.134    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 677,977
Number of extensions: 1121
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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