Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000542                                                              20     299
NP_937799                                                              20     299
NP_001094058                                                           17    4312
NP_061323                                                              17    4312
NP_003631                                                              16    5631
NP_001032                                                              16    5631
XP_005252342                                                           16    5631
NP_958843                                                              16    7355
NP_660312                                                              16    7355
NP_001269963                                                           16    7355
NP_001006635                                                           16    7355
NP_060524                                                              16    7355
XP_006721123                                                           16    7355
XP_005255471                                                           16    7355
XP_006721121                                                           16    7355
XP_005255470                                                           16    7355
XP_006721120                                                           16    7355
XP_006719709                                                           16    7355
XP_006719708                                                           16    7355
XP_006719707                                                           16    7355
XP_006719706                                                           16    7355
XP_006716569                                                           16    7355
XP_005250844                                                           16    7355
XP_005250843                                                           16    7355
XP_005250841                                                           16    7355
XP_005250840                                                           16    7355
NP_001104537                                                           15    9605
NP_001096                                                              15    9605
NP_690051                                                              15    9605
NP_006038                                                              15    9605
NP_001185769                                                           15    9605
NP_001185767                                                           15    9605
NP_002800                                                              15    9605
NP_078813                                                              15    9605
NP_055553                                                              15    9605
NP_640332                                                              15    9605
NP_001267730                                                           15    9605
NP_060904                                                              15    9605
NP_775922                                                              15    9605
XP_006723507                                                           15    9605
XP_005259397                                                           15    9605
XP_005257925                                                           15    9605
XP_005257924                                                           15    9605
XP_005257923                                                           15    9605
XP_005257922                                                           15    9605
XP_005257921                                                           15    9605
XP_006722263                                                           15    9605
XP_005257920                                                           15    9605
XP_006714953                                                           15    9605
XP_006712888                                                           15    9605
XP_005246996                                                           15    9605
XP_005246997                                                           15    9605
>NP_000542
          Length = 213

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YKRLDIVRS 9
           Y+RLDIVRS
Sbjct: 175 YRRLDIVRS 183
>NP_937799
          Length = 172

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   YKRLDIVRS 9
           Y+RLDIVRS
Sbjct: 134 YRRLDIVRS 142
>NP_001094058
          Length = 1191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YKRLDIVRS 9
           Y+R DI+RS
Sbjct: 706 YQRDDIIRS 714
>NP_061323
          Length = 1064

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   YKRLDIVRS 9
           Y+R DI+RS
Sbjct: 706 YQRDDIIRS 714
>NP_003631
          Length = 1332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    YKRLDIVRS 9
            Y RLDI+ +
Sbjct: 1099 YNRLDIIET 1107
>NP_001032
          Length = 1827

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKRLDIVR 8
           YK LD+V+
Sbjct: 362 YKSLDVVK 369
>XP_005252342
          Length = 1218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   YKRLDIVRS 9
           Y RLDI+ +
Sbjct: 985 YNRLDIIET 993
>NP_958843
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YKRLDIVRS 9
          +KR +I+RS
Sbjct: 80 HKRTEIIRS 88
>NP_660312
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLDIVRS 9
           RLDIVR+
Sbjct: 233 RLDIVRA 239
>NP_001269963
          Length = 251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLDIVRS 9
           RLDIVR+
Sbjct: 195 RLDIVRA 201
>NP_001006635
          Length = 881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KRLDIVRS 9
          +RLD VRS
Sbjct: 34 RRLDTVRS 41
>NP_060524
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KRLDIVRS 9
          +RLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_006721123
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KRLDIVRS 9
          +RLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_005255471
          Length = 840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KRLDIVRS 9
          +RLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_006721121
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KRLDIVRS 9
          +RLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_005255470
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KRLDIVRS 9
          +RLD VRS
Sbjct: 34 RRLDTVRS 41
>XP_006721120
          Length = 880

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KRLDIVRS 9
          +RLD VRS
Sbjct: 33 RRLDTVRS 40
>XP_006719709
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YKRLDIVRS 9
          +KR +I+RS
Sbjct: 80 HKRTEIIRS 88
>XP_006719708
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YKRLDIVRS 9
          +KR +I+RS
Sbjct: 80 HKRTEIIRS 88
>XP_006719707
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YKRLDIVRS 9
          +KR +I+RS
Sbjct: 80 HKRTEIIRS 88
>XP_006719706
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  YKRLDIVRS 9
          +KR +I+RS
Sbjct: 80 HKRTEIIRS 88
>XP_006716569
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLDIVRS 9
           RLDIVR+
Sbjct: 233 RLDIVRA 239
>XP_005250844
          Length = 219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLDIVRS 9
           RLDIVR+
Sbjct: 163 RLDIVRA 169
>XP_005250843
          Length = 227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLDIVRS 9
           RLDIVR+
Sbjct: 171 RLDIVRA 177
>XP_005250841
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLDIVRS 9
           RLDIVR+
Sbjct: 203 RLDIVRA 209
>XP_005250840
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RLDIVRS 9
           RLDIVR+
Sbjct: 241 RLDIVRA 247
>NP_001104537
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKRLDI 6
           YKR+DI
Sbjct: 399 YKRVDI 404
>NP_001096
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKRLDI 6
           YKR+DI
Sbjct: 399 YKRVDI 404
>NP_690051
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YKRLDIV 7
           +K+LDIV
Sbjct: 450 FKKLDIV 456
>NP_006038
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YKRLDIV 7
           +K+LDIV
Sbjct: 450 FKKLDIV 456
>NP_001185769
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YKRLDIV 7
           +K+LDIV
Sbjct: 450 FKKLDIV 456
>NP_001185767
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   YKRLDIV 7
           +K+LDIV
Sbjct: 450 FKKLDIV 456
>NP_002800
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RLDIVRS 9
           +LD+VRS
Sbjct: 223 KLDVVRS 229
>NP_078813
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKRLDIVR 8
           Y R DI+R
Sbjct: 94  YVRFDIIR 101
>NP_055553
          Length = 1356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLDIVR 8
           RLDIVR
Sbjct: 834 RLDIVR 839
>NP_640332
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  YKRLDI 6
          Y+RLDI
Sbjct: 75 YRRLDI 80
>NP_001267730
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKRLDIVR 8
           YK+ D+VR
Sbjct: 271 YKQNDVVR 278
>NP_060904
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKRLDIVR 8
           YK+ D+VR
Sbjct: 271 YKQNDVVR 278
>NP_775922
          Length = 6996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKRLDIVR 8
           YKR DI++
Sbjct: 198 YKRKDILK 205
>XP_006723507
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  YKRLDI 6
          Y+RLDI
Sbjct: 90 YRRLDI 95
>XP_005259397
          Length = 328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  YKRLDI 6
          Y+RLDI
Sbjct: 90 YRRLDI 95
>XP_005257925
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLDIVR 8
           RLDIVR
Sbjct: 298 RLDIVR 303
>XP_005257924
          Length = 1122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLDIVR 8
           RLDIVR
Sbjct: 570 RLDIVR 575
>XP_005257923
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLDIVR 8
           RLDIVR
Sbjct: 579 RLDIVR 584
>XP_005257922
          Length = 1366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLDIVR 8
           RLDIVR
Sbjct: 844 RLDIVR 849
>XP_005257921
          Length = 1370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLDIVR 8
           RLDIVR
Sbjct: 848 RLDIVR 853
>XP_006722263
          Length = 1390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLDIVR 8
           RLDIVR
Sbjct: 838 RLDIVR 843
>XP_005257920
          Length = 1390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RLDIVR 8
           RLDIVR
Sbjct: 838 RLDIVR 843
>XP_006714953
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKRLDIVR 8
           YK+ D+VR
Sbjct: 271 YKQNDVVR 278
>XP_006712888
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKRLDI 6
           YKR+DI
Sbjct: 399 YKRVDI 404
>XP_005246996
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKRLDI 6
           YKR+DI
Sbjct: 399 YKRVDI 404
>XP_005246997
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKRLDI 6
           YKR+DI
Sbjct: 399 YKRVDI 404
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.147    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 427,284
Number of extensions: 609
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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