Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1135
NP_001075109                                                           18    1135
NP_006198                                                              16    5631
NP_001167554                                                           16    5631
NP_001167553                                                           16    5631
NP_060322                                                              16    5631
NP_000360                                                              16    5631
NP_001167552                                                           16    5631
XP_005268094                                                           16    5631
NP_976249                                                              16    7355
NP_001128302                                                           15    9605
NP_060121                                                              15    9605
NP_001128303                                                           15    9605
NP_001128304                                                           15    9605
NP_071406                                                              15    9605
NP_775182                                                              15    9605
NP_055726                                                              15    9605
NP_001158221                                                           15    9605
NP_001159365                                                           15    9605
NP_000048                                                              15    9605
NP_001274177                                                           15    9605
NP_001274176                                                           15    9605
NP_001274175                                                           15    9605
NP_060015                                                              15    9605
XP_006720695                                                           15    9605
XP_005268050                                                           15    9605
XP_005268049                                                           15    9605
XP_005268048                                                           15    9605
XP_005267096                                                           15    9605
XP_006715570                                                           15    9605
XP_005246685                                                           15    9605
XP_005246683                                                           15    9605
NP_009007                                                              15    9605
>NP_008835
          Length = 4128

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YKLL ITVR
Sbjct: 667 YKLLSITVR 675
>NP_001075109
          Length = 4097

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YKLL ITVR
Sbjct: 667 YKLLSITVR 675
>NP_006198
          Length = 375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   YKLLYITV 8
           Y+LLY+ V
Sbjct: 260 YQLLYVAV 267
>NP_001167554
          Length = 1039

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLLYITVR 9
           KLLY T+R
Sbjct: 806 KLLYTTLR 813
>NP_001167553
          Length = 1040

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLLYITVR 9
           KLLY T+R
Sbjct: 807 KLLYTTLR 814
>NP_060322
          Length = 1062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLLYITVR 9
           KLLY T+R
Sbjct: 829 KLLYTTLR 836
>NP_000360
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKLLYITVR 9
           Y  +YITVR
Sbjct: 601 YVKIYITVR 609
>NP_001167552
          Length = 1062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLLYITVR 9
           KLLY T+R
Sbjct: 829 KLLYTTLR 836
>XP_005268094
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   YKLLYITVR 9
           Y  +YITVR
Sbjct: 601 YVKIYITVR 609
>NP_976249
          Length = 211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           Y+LL +T+R
Sbjct: 187 YELLALTIR 195
>NP_001128302
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LYITVR 9
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_060121
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LYITVR 9
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_001128303
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LYITVR 9
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_001128304
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LYITVR 9
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_071406
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YK+++IT R
Sbjct: 251 YKVIHITGR 259
>NP_775182
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YK+++IT R
Sbjct: 270 YKVIHITGR 278
>NP_055726
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   YKLLYITV 8
           YKL Y T+
Sbjct: 253 YKLCYFTL 260
>NP_001158221
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YK+++IT R
Sbjct: 283 YKVIHITGR 291
>NP_001159365
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YK+++IT R
Sbjct: 253 YKVIHITGR 261
>NP_000048
          Length = 1417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KLLYIT 7
           KLLY+T
Sbjct: 761 KLLYVT 766
>NP_001274177
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KLLYIT 7
           KLLY+T
Sbjct: 386 KLLYVT 391
>NP_001274176
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KLLYIT 7
           KLLY+T
Sbjct: 761 KLLYVT 766
>NP_001274175
          Length = 1417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KLLYIT 7
           KLLY+T
Sbjct: 761 KLLYVT 766
>NP_060015
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   YKLLYITV 8
           YK +++TV
Sbjct: 152 YKAIFVTV 159
>XP_006720695
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KLLYIT 7
           KLLY+T
Sbjct: 107 KLLYVT 112
>XP_005268050
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YK+++IT R
Sbjct: 270 YKVIHITGR 278
>XP_005268049
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YK+++IT R
Sbjct: 288 YKVIHITGR 296
>XP_005268048
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   YKLLYITVR 9
           YK+++IT R
Sbjct: 290 YKVIHITGR 298
>XP_005267096
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LYITVR 9
           LY+TVR
Sbjct: 530 LYVTVR 535
>XP_006715570
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   LYITVR 9
           LY+TVR
Sbjct: 530 LYVTVR 535
>XP_005246685
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YKLLYITV 8
          Y+LL ITV
Sbjct: 4  YRLLSITV 11
>XP_005246683
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  YKLLYITV 8
          Y+LL ITV
Sbjct: 4  YRLLSITV 11
>NP_009007
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   YKLLYI 6
           YKL+YI
Sbjct: 357 YKLVYI 362
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.155    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 420,778
Number of extensions: 578
Number of successful extensions: 33
Number of sequences better than 10000.0: 33
Number of HSP's gapped: 33
Number of HSP's successfully gapped: 33
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package