Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000224                                                              20     299
NP_000360                                                              20     299
XP_005268094                                                           20     299
XP_005264366                                                           20     299
XP_006712078                                                           20     299
NP_852111                                                              19     869
NP_000136                                                              19     869
NP_001786                                                              16    5631
NP_001001967                                                           16    5631
NP_065866                                                              16    7355
NP_116586                                                              16    7355
NP_006197                                                              16    7355
NP_001005493                                                           16    7355
NP_001777                                                              16    7355
NP_078858                                                              16    7355
NP_001278232                                                           16    7355
NP_001278214                                                           16    7355
NP_057613                                                              16    7355
NP_071407                                                              16    7355
NP_001275918                                                           16    7355
NP_001159451                                                           16    7355
NP_006086                                                              16    7355
NP_001098999                                                           16    7355
NP_057425                                                              16    7355
NP_065831                                                              16    7355
NP_005062                                                              16    7355
XP_006722907                                                           16    7355
XP_006722906                                                           16    7355
XP_006722905                                                           16    7355
XP_006719897                                                           16    7355
XP_006719896                                                           16    7355
XP_006719895                                                           16    7355
XP_005266476                                                           16    7355
XP_006718146                                                           16    7355
XP_006718145                                                           16    7355
XP_005270360                                                           16    7355
XP_006718005                                                           16    7355
XP_006718004                                                           16    7355
XP_006718003                                                           16    7355
XP_006717953                                                           16    7355
XP_006717952                                                           16    7355
XP_006717951                                                           16    7355
XP_006717950                                                           16    7355
XP_006717949                                                           16    7355
XP_006717948                                                           16    7355
XP_006714104                                                           16    7355
XP_005265800                                                           16    7355
XP_006714103                                                           16    7355
XP_006714102                                                           16    7355
XP_006714052                                                           16    7355
XP_005248100                                                           16    7355
XP_005275746                                                           16    7355
XP_003403671                                                           16    7355
XP_006710003                                                           16    7355
NP_001005197                                                           16    7355
NP_001005213                                                           16    7355
NP_003688                                                              16    7355
NP_001013376                                                           16    7355
NP_078966                                                              15    9605
NP_003348                                                              15    9605
NP_006574                                                              15    9605
NP_001004477                                                           15    9605
>NP_000224
          Length = 699

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VYTLTVVTL 9
           VYTLTV+TL
Sbjct: 454 VYTLTVITL 462
>NP_000360
          Length = 764

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VYTLTVVTL 9
           VYTLTV+TL
Sbjct: 509 VYTLTVITL 517
>XP_005268094
          Length = 764

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VYTLTVVTL 9
           VYTLTV+TL
Sbjct: 509 VYTLTVITL 517
>XP_005264366
          Length = 380

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VYTLTVVTL 9
           VYTLTV+TL
Sbjct: 135 VYTLTVITL 143
>XP_006712078
          Length = 389

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VYTLTVVTL 9
           VYTLTV+TL
Sbjct: 144 VYTLTVITL 152
>NP_852111
          Length = 669

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VYTLTVVTL 9
           VYTLT +TL
Sbjct: 431 VYTLTAITL 439
>NP_000136
          Length = 695

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   VYTLTVVTL 9
           VYTLT +TL
Sbjct: 457 VYTLTAITL 465
>NP_001786
          Length = 784

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VYTLTVVTL 9
           + T+TV+TL
Sbjct: 608 ILTITVITL 616
>NP_001001967
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VYTLTVV 7
          VYT+TVV
Sbjct: 36 VYTVTVV 42
>NP_065866
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YTLTVV 7
           YTLTVV
Sbjct: 429 YTLTVV 434
>NP_116586
          Length = 1040

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   YTLTVV 7
           YTLTVV
Sbjct: 429 YTLTVV 434
>NP_006197
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VYTLTV 6
           VYTLTV
Sbjct: 272 VYTLTV 277
>NP_001005493
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YTLTVVTL 9
           +TL VVTL
Sbjct: 198 FTLAVVTL 205
>NP_001777
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  VVTL
Sbjct: 159 VYTHEVVTL 167
>NP_078858
          Length = 4981

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 2120 YTLTVV 2125
>NP_001278232
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 2120 YTLTVV 2125
>NP_001278214
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 2120 YTLTVV 2125
>NP_057613
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VYTLTVVTL 9
            VYT  VVT+
Sbjct: 1004 VYTYVVVTV 1012
>NP_071407
          Length = 3354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 1385 YTLTVV 1390
>NP_001275918
          Length = 2286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1854 VYSLTIVS 1861
>NP_001159451
          Length = 1994

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1562 VYSLTIVS 1569
>NP_006086
          Length = 1164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  V+T+
Sbjct: 984 VYTFVVITV 992
>NP_001098999
          Length = 1149

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  V+T+
Sbjct: 969 VYTFVVITV 977
>NP_057425
          Length = 2302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1870 VYSLTIVS 1877
>NP_065831
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    VYTLTVVT 8
            +YTLTV T
Sbjct: 1331 LYTLTVST 1338
>NP_005062
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VYTLTVV 7
           +YTLTV+
Sbjct: 341 MYTLTVI 347
>XP_006722907
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VYTLTVV 7
           +YTLTV+
Sbjct: 341 MYTLTVI 347
>XP_006722906
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VYTLTVV 7
           +YTLTV+
Sbjct: 341 MYTLTVI 347
>XP_006722905
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VYTLTVV 7
           +YTLTV+
Sbjct: 341 MYTLTVI 347
>XP_006719897
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  VVT+
Sbjct: 964 VYTYVVVTV 972
>XP_006719896
          Length = 1005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  VVT+
Sbjct: 821 VYTYVVVTV 829
>XP_006719895
          Length = 1082

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  VVT+
Sbjct: 898 VYTYVVVTV 906
>XP_005266476
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  VVT+
Sbjct: 964 VYTYVVVTV 972
>XP_006718146
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  VVTL
Sbjct: 159 VYTHEVVTL 167
>XP_006718145
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  VVTL
Sbjct: 159 VYTHEVVTL 167
>XP_005270360
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  VVTL
Sbjct: 159 VYTHEVVTL 167
>XP_006718005
          Length = 3397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 1428 YTLTVV 1433
>XP_006718004
          Length = 3399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 1430 YTLTVV 1435
>XP_006718003
          Length = 3419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 1450 YTLTVV 1455
>XP_006717953
          Length = 2008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1576 VYSLTIVS 1583
>XP_006717952
          Length = 2300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1868 VYSLTIVS 1875
>XP_006717951
          Length = 2315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1883 VYSLTIVS 1890
>XP_006717950
          Length = 2316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1884 VYSLTIVS 1891
>XP_006717949
          Length = 2316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1884 VYSLTIVS 1891
>XP_006717948
          Length = 2316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    VYTLTVVT 8
            VY+LT+V+
Sbjct: 1884 VYSLTIVS 1891
>XP_006714104
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VYTLTV 6
           VYTLTV
Sbjct: 297 VYTLTV 302
>XP_005265800
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VYTLTV 6
           VYTLTV
Sbjct: 272 VYTLTV 277
>XP_006714103
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VYTLTV 6
           VYTLTV
Sbjct: 294 VYTLTV 299
>XP_006714102
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VYTLTV 6
           VYTLTV
Sbjct: 297 VYTLTV 302
>XP_006714052
          Length = 1000

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  V+T+
Sbjct: 820 VYTFVVITV 828
>XP_005248100
          Length = 1164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYTLTVVTL 9
           VYT  V+T+
Sbjct: 984 VYTFVVITV 992
>XP_005275746
          Length = 3352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 1383 YTLTVV 1388
>XP_003403671
          Length = 3354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 1385 YTLTVV 1390
>XP_006710003
          Length = 3374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    YTLTVV 7
            YTLTVV
Sbjct: 1405 YTLTVV 1410
>NP_001005197
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VYTLTVV 7
          +YT+TVV
Sbjct: 34 IYTVTVV 40
>NP_001005213
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VYTLTVV 7
          VY+LTVV
Sbjct: 33 VYSLTVV 39
>NP_003688
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VYTLTVV 7
          +YTLTV+
Sbjct: 34 IYTLTVL 40
>NP_001013376
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VYTLTVV 7
          VY+LTVV
Sbjct: 33 VYSLTVV 39
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   YTLTVVT 8
           YTLTV T
Sbjct: 147 YTLTVET 153
>NP_003348
          Length = 91

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TLTVVTL 9
          TLT+VTL
Sbjct: 6  TLTLVTL 12
>NP_006574
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YTLTVVTL 9
           YT+TV+ +
Sbjct: 189 YTMTVIAI 196
>NP_001004477
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  YTLTVV 7
          YTLT+V
Sbjct: 89 YTLTIV 94
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.138    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 322,323
Number of extensions: 495
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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