Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     509
NP_001094299                                                           17    3301
NP_078858                                                              17    4312
NP_001278232                                                           17    4312
NP_001278214                                                           17    4312
NP_937762                                                              16    5631
NP_001121190                                                           16    5631
NP_000218                                                              16    5631
NP_001121189                                                           16    5631
NP_004426                                                              16    5631
NP_055918                                                              16    5631
NP_001275682                                                           16    5631
NP_005487                                                              16    5631
NP_065995                                                              16    5631
NP_001002800                                                           16    5631
XP_005251583                                                           16    5631
XP_006716872                                                           16    5631
XP_006713522                                                           16    5631
NP_001267474                                                           16    7355
NP_060732                                                              16    7355
NP_443715                                                              16    7355
NP_443716                                                              16    7355
NP_001267470                                                           16    7355
NP_443711                                                              16    7355
NP_001267475                                                           16    7355
NP_065829                                                              16    7355
NP_115919                                                              16    7355
NP_072174                                                              16    7355
XP_005256884                                                           16    7355
XP_006713758                                                           16    7355
XP_006713757                                                           16    7355
XP_006713756                                                           16    7355
XP_005247668                                                           16    7355
XP_006713755                                                           16    7355
XP_005247667                                                           16    7355
XP_005247666                                                           16    7355
XP_005247665                                                           16    7355
XP_005247664                                                           16    7355
XP_006713754                                                           16    7355
XP_006713753                                                           16    7355
XP_005247661                                                           16    7355
XP_006713752                                                           16    7355
XP_005247660                                                           16    7355
XP_006712785                                                           16    7355
XP_005246883                                                           16    7355
XP_005246882                                                           16    7355
XP_006712784                                                           16    7355
NP_001006659                                                           15    9605
NP_001868                                                              15    9605
NP_619639                                                              15    9605
NP_001277007                                                           15    9605
NP_000450                                                              15    9605
NP_001277006                                                           15    9605
NP_055855                                                              15    9605
NP_004709                                                              15    9605
NP_005617                                                              15    9605
NP_001243069                                                           15    9605
NP_001738                                                              15    9605
NP_001243068                                                           15    9605
NP_004642                                                              15    9605
XP_005272731                                                           15    9605
XP_005251620                                                           15    9605
XP_005251618                                                           15    9605
XP_006712425                                                           15    9605
XP_006712424                                                           15    9605
XP_005264639                                                           15    9605
XP_005264638                                                           15    9605
NP_892003                                                              15    9605
NP_115564                                                              15    9605
NP_004482                                                              15    9605
>NP_443179
          Length = 2170

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VYQISGKNS 9
          VYQIS KNS
Sbjct: 84 VYQISAKNS 92
>NP_001094299
          Length = 132

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VYQISGKN 8
           +Y+++GKN
Sbjct: 96  IYRVAGKN 103
>NP_078858
          Length = 4981

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YQISGKNS 9
            Y +SG+NS
Sbjct: 2503 YSLSGRNS 2510
>NP_001278232
          Length = 4983

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YQISGKNS 9
            Y +SG+NS
Sbjct: 2505 YSLSGRNS 2512
>NP_001278214
          Length = 4982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    YQISGKNS 9
            Y +SG+NS
Sbjct: 2505 YSLSGRNS 2512
>NP_937762
          Length = 3333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VYQISGKNS 9
            VY + G+NS
Sbjct: 2517 VYDMDGRNS 2525
>NP_001121190
          Length = 1668

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYQISGKNS 9
           VY + G+NS
Sbjct: 852 VYDMDGRNS 860
>NP_000218
          Length = 1724

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYQISGKNS 9
           VY + G+NS
Sbjct: 908 VYDMDGRNS 916
>NP_001121189
          Length = 3277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VYQISGKNS 9
            VY + G+NS
Sbjct: 2461 VYDMDGRNS 2469
>NP_004426
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   YQISGKN 8
           YQ+ GKN
Sbjct: 215 YQVIGKN 221
>NP_055918
          Length = 1925

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  VYQISGKN 8
          +YQ+SG N
Sbjct: 79 LYQLSGAN 86
>NP_001275682
          Length = 1263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VYQISGK 7
           VY ISGK
Sbjct: 171 VYHISGK 177
>NP_005487
          Length = 1288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VYQISGK 7
           VY ISGK
Sbjct: 196 VYHISGK 202
>NP_065995
          Length = 927

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYQISGKN 8
           VYQ+ G+N
Sbjct: 238 VYQLPGQN 245
>NP_001002800
          Length = 1288

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VYQISGK 7
           VY ISGK
Sbjct: 196 VYHISGK 202
>XP_005251583
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYQISGKN 8
           VYQ+ G+N
Sbjct: 244 VYQLPGQN 251
>XP_006716872
          Length = 933

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VYQISGKN 8
           VYQ+ G+N
Sbjct: 244 VYQLPGQN 251
>XP_006713522
          Length = 1210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VYQISGK 7
           VY ISGK
Sbjct: 196 VYHISGK 202
>NP_001267474
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 116 YQLSGK 121
>NP_060732
          Length = 1182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 207 YQLSGK 212
>NP_443715
          Length = 1241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 266 YQLSGK 271
>NP_443716
          Length = 1131

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 155 YQLSGK 160
>NP_001267470
          Length = 1234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 258 YQLSGK 263
>NP_443711
          Length = 1292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 317 YQLSGK 322
>NP_001267475
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  YQISGK 7
          YQ+SGK
Sbjct: 57 YQLSGK 62
>NP_065829
          Length = 1907

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VYQISGKNS 9
           +YQ S +NS
Sbjct: 351 IYQASAQNS 359
>NP_115919
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   YQISGKN 8
           Y++SG+N
Sbjct: 101 YEVSGQN 107
>NP_072174
          Length = 1735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VYQISG 6
            VYQ+SG
Sbjct: 1253 VYQVSG 1258
>XP_005256884
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   YQISGKN 8
           Y++SG+N
Sbjct: 101 YEVSGQN 107
>XP_006713758
          Length = 877

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 266 YQLSGK 271
>XP_006713757
          Length = 1034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  YQISGK 7
          YQ+SGK
Sbjct: 57 YQLSGK 62
>XP_006713756
          Length = 1093

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 116 YQLSGK 121
>XP_005247668
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 155 YQLSGK 160
>XP_006713755
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 207 YQLSGK 212
>XP_005247667
          Length = 1183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 207 YQLSGK 212
>XP_005247666
          Length = 1183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 207 YQLSGK 212
>XP_005247665
          Length = 1184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 207 YQLSGK 212
>XP_005247664
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 214 YQLSGK 219
>XP_006713754
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 266 YQLSGK 271
>XP_006713753
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 266 YQLSGK 271
>XP_005247661
          Length = 1242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 266 YQLSGK 271
>XP_006713752
          Length = 1242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 266 YQLSGK 271
>XP_005247660
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YQISGK 7
           YQ+SGK
Sbjct: 266 YQLSGK 271
>XP_006712785
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VYQISG 6
           VYQ+SG
Sbjct: 870 VYQVSG 875
>XP_005246883
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   VYQISG 6
           VYQ+SG
Sbjct: 870 VYQVSG 875
>XP_005246882
          Length = 1518

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VYQISG 6
            VYQ+SG
Sbjct: 1036 VYQVSG 1041
>XP_006712784
          Length = 1784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    VYQISG 6
            VYQ+SG
Sbjct: 1302 VYQVSG 1307
>NP_001006659
          Length = 1092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YQISGKNS 9
           Y+ISGK +
Sbjct: 611 YKISGKEA 618
>NP_001868
          Length = 1033

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YQISGKNS 9
           Y+ISGK +
Sbjct: 611 YKISGKEA 618
>NP_619639
          Length = 4074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2    YQISGKN 8
            YQ++G+N
Sbjct: 4009 YQLAGQN 4015
>NP_001277007
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YQISGKN 8
           Y++ GKN
Sbjct: 527 YKVQGKN 533
>NP_000450
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YQISGKN 8
           Y++ GKN
Sbjct: 674 YKVQGKN 680
>NP_001277006
          Length = 1081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YQISGKN 8
           Y++ GKN
Sbjct: 631 YKVQGKN 637
>NP_055855
          Length = 2098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VYQISGKNS 9
            VY+I  KNS
Sbjct: 1916 VYRIGYKNS 1924
>NP_004709
          Length = 114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  VYQISGKN 8
          VY  +GKN
Sbjct: 51 VYDYAGKN 58
>NP_005617
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  VYQISGKN 8
          VY+++GK+
Sbjct: 52 VYELNGKD 59
>NP_001243069
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VYQISGKNS 9
           +YQ+ GK +
Sbjct: 139 LYQVKGKKN 147
>NP_001738
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VYQISGKNS 9
           +YQ+ GK +
Sbjct: 139 LYQVKGKKN 147
>NP_001243068
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VYQISGKNS 9
           +YQ+ GK +
Sbjct: 139 LYQVKGKKN 147
>NP_004642
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VYQISGK 7
           VY++SG+
Sbjct: 571 VYEVSGR 577
>XP_005272731
          Length = 690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VYQISGK 7
           VY++SG+
Sbjct: 298 VYEVSGR 304
>XP_005251620
          Length = 1080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YQISGKN 8
           Y++ GKN
Sbjct: 631 YKVQGKN 637
>XP_005251618
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   YQISGKN 8
           Y++ GKN
Sbjct: 674 YKVQGKN 680
>XP_006712425
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VYQISGKNS 9
            VY+I  KNS
Sbjct: 1167 VYRIGYKNS 1175
>XP_006712424
          Length = 1376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VYQISGKNS 9
            VY+I  KNS
Sbjct: 1194 VYRIGYKNS 1202
>XP_005264639
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VYQISGKNS 9
           +YQ+ GK +
Sbjct: 139 LYQVKGKKN 147
>XP_005264638
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   VYQISGKNS 9
           +YQ+ GK +
Sbjct: 139 LYQVKGKKN 147
>NP_892003
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VYQISGKN 8
           VY++ GK+
Sbjct: 248 VYEVDGKD 255
>NP_115564
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VYQISGKN 8
           VY++ GK+
Sbjct: 248 VYEVDGKD 255
>NP_004482
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    VYQISGKNS 9
            +Y++SG  S
Sbjct: 1282 IYRVSGNKS 1290
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.122    0.317 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 653,828
Number of extensions: 1569
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package