Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004963                                                              20     299
XP_005251512                                                           20     299
NP_004275                                                              18    1482
NP_001243265                                                           18    1482
NP_078844                                                              18    1482
NP_001243267                                                           18    1482
XP_006711702                                                           18    1482
XP_006711701                                                           18    1482
XP_006711700                                                           18    1482
XP_006711699                                                           18    1482
NP_001186084                                                           17    3301
NP_001186085                                                           17    3301
NP_001186087                                                           17    3301
NP_001186086                                                           17    3301
NP_008998                                                              17    3301
NP_001264880                                                           17    3301
NP_001264876                                                           17    3301
NP_001264878                                                           17    3301
NP_001099022                                                           17    3301
NP_001099021                                                           17    3301
NP_001099020                                                           17    3301
NP_001099019                                                           17    3301
NP_001264881                                                           17    3301
NP_001264877                                                           17    3301
NP_001264875                                                           17    3301
NP_060770                                                              17    3301
NP_001264874                                                           17    3301
NP_006059                                                              16    5631
XP_005262694                                                           16    5631
XP_005262693                                                           16    5631
XP_005245660                                                           16    7355
NP_001073895                                                           16    7355
NP_005493                                                              15    9605
NP_775828                                                              15    9605
NP_033720                                                              15    9605
NP_958934                                                              15    9605
NP_001149                                                              15    9605
XP_005266711                                                           15    9605
XP_005266710                                                           15    9605
XP_005266709                                                           15    9605
XP_005266708                                                           15    9605
XP_005266707                                                           15    9605
XP_005251837                                                           15    9605
XP_005251835                                                           15    9605
XP_006717058                                                           15    9605
XP_005251833                                                           15    9605
XP_005251831                                                           15    9605
XP_005251830                                                           15    9605
NP_005536                                                              15    9605
>NP_004963
          Length = 1132

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VYHNMSALM 9
          VYHNM ALM
Sbjct: 80 VYHNMFALM 88
>XP_005251512
          Length = 1132

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VYHNMSALM 9
          VYHNM ALM
Sbjct: 80 VYHNMFALM 88
>NP_004275
          Length = 897

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YH MSAL
Sbjct: 278 IYHGMSAL 285
>NP_001243265
          Length = 797

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YH MSAL
Sbjct: 178 IYHGMSAL 185
>NP_078844
          Length = 784

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YH MSAL
Sbjct: 165 IYHGMSAL 172
>NP_001243267
          Length = 693

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VYHNMSAL 8
          +YH MSAL
Sbjct: 74 IYHGMSAL 81
>XP_006711702
          Length = 784

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YH MSAL
Sbjct: 165 IYHGMSAL 172
>XP_006711701
          Length = 792

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YH MSAL
Sbjct: 278 IYHGMSAL 285
>XP_006711700
          Length = 803

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YH MSAL
Sbjct: 278 IYHGMSAL 285
>XP_006711699
          Length = 825

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YH MSAL
Sbjct: 206 IYHGMSAL 213
>NP_001186084
          Length = 581

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VYHNMSA 7
           +YHN+SA
Sbjct: 211 LYHNLSA 217
>NP_001186085
          Length = 472

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VYHNMSA 7
          +YHN+SA
Sbjct: 72 LYHNLSA 78
>NP_001186087
          Length = 442

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VYHNMSA 7
          +YHN+SA
Sbjct: 72 LYHNLSA 78
>NP_001186086
          Length = 501

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VYHNMSA 7
           +YHN+SA
Sbjct: 131 LYHNLSA 137
>NP_008998
          Length = 611

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VYHNMSA 7
           +YHN+SA
Sbjct: 211 LYHNLSA 217
>NP_001264880
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001264876
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001264878
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001099022
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001099021
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001099020
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001099019
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001264881
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001264877
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001264875
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_060770
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_001264874
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           V+HNMS L
Sbjct: 157 VFHNMSHL 164
>NP_006059
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YHNMSALM 9
           YH + ALM
Sbjct: 748 YHKLKALM 755
>XP_005262694
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YHNMSALM 9
           YH + ALM
Sbjct: 748 YHKLKALM 755
>XP_005262693
          Length = 796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YHNMSALM 9
           YH + ALM
Sbjct: 748 YHKLKALM 755
>XP_005245660
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           ++HNM+ L
Sbjct: 242 IFHNMAIL 249
>NP_001073895
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           ++HNM+ L
Sbjct: 242 IFHNMAIL 249
>NP_005493
          Length = 2261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   VYHNMS 6
           +YHN+S
Sbjct: 158 LYHNLS 163
>NP_775828
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VYHNMSAL 8
           V HNMS +
Sbjct: 186 VLHNMSCI 193
>NP_033720
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YHN+S +
Sbjct: 223 LYHNISGV 230
>NP_958934
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HNMSAL 8
           HN+SAL
Sbjct: 119 HNLSAL 124
>NP_001149
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VYHNMSAL 8
           +YHN+S +
Sbjct: 223 LYHNISGV 230
>XP_005266711
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VYHNMSAL 8
           V HNMS +
Sbjct: 186 VLHNMSCI 193
>XP_005266710
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VYHNMSAL 8
           V HNMS +
Sbjct: 186 VLHNMSCI 193
>XP_005266709
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VYHNMSAL 8
           V HNMS +
Sbjct: 186 VLHNMSCI 193
>XP_005266708
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VYHNMSAL 8
           V HNMS +
Sbjct: 186 VLHNMSCI 193
>XP_005266707
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VYHNMSAL 8
           V HNMS +
Sbjct: 186 VLHNMSCI 193
>XP_005251837
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   VYHNMS 6
           +YHN+S
Sbjct: 158 LYHNLS 163
>XP_005251835
          Length = 2074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   VYHNMS 6
           +YHN+S
Sbjct: 158 LYHNLS 163
>XP_006717058
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   VYHNMS 6
           +YHN+S
Sbjct: 158 LYHNLS 163
>XP_005251833
          Length = 2203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   VYHNMS 6
           +YHN+S
Sbjct: 98  LYHNLS 103
>XP_005251831
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   VYHNMS 6
           +YHN+S
Sbjct: 158 LYHNLS 163
>XP_005251830
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   VYHNMS 6
           +YHN+S
Sbjct: 158 LYHNLS 163
>NP_005536
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HNMSAL 8
           HN+SAL
Sbjct: 119 HNLSAL 124
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.126    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,453
Number of extensions: 331
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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