Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              19     665
NP_996844                                                              18    1935
XP_005254439                                                           18    1935
XP_006720568                                                           18    1935
XP_005254438                                                           18    1935
NP_002335                                                              18    1935
NP_001244211                                                           17    3301
NP_078807                                                              17    3301
NP_001240744                                                           17    3301
NP_001240745                                                           17    3301
NP_001244210                                                           17    3301
NP_689596                                                              17    3301
NP_001098047                                                           17    3301
NP_060456                                                              17    3301
XP_005256766                                                           17    3301
XP_006716723                                                           17    3301
XP_006716722                                                           17    3301
XP_006716721                                                           17    3301
NP_000085                                                              16    5631
NP_780775                                                              16    5631
NP_001230199                                                           16    5631
NP_055176                                                              16    5631
NP_001006635                                                           16    5631
NP_060524                                                              16    5631
NP_001230200                                                           16    5631
XP_006721123                                                           16    5631
XP_006721122                                                           16    5631
XP_005255471                                                           16    5631
XP_006721121                                                           16    5631
XP_005255470                                                           16    5631
XP_006721120                                                           16    5631
NP_008986                                                              16    7355
NP_056517                                                              16    7355
NP_114409                                                              16    7355
NP_006865                                                              16    7355
NP_001263388                                                           16    7355
NP_001263387                                                           16    7355
NP_001263386                                                           16    7355
NP_071373                                                              16    7355
NP_973728                                                              16    7355
NP_060382                                                              16    7355
NP_001158608                                                           16    7355
XP_006717660                                                           16    7355
XP_005266015                                                           16    7355
XP_005263140                                                           16    7355
XP_006714193                                                           16    7355
XP_005262863                                                           16    7355
XP_006714192                                                           16    7355
XP_005262862                                                           16    7355
XP_006714191                                                           16    7355
XP_005262861                                                           16    7355
XP_005262860                                                           16    7355
NP_150597                                                              16    7355
NP_001128302                                                           15    9605
NP_060121                                                              15    9605
NP_001128303                                                           15    9605
NP_001128304                                                           15    9605
NP_997299                                                              15    9605
NP_001138669                                                           15    9605
NP_002514                                                              15    9605
NP_037422                                                              15    9605
NP_001186125                                                           15    9605
NP_057640                                                              15    9605
NP_219483                                                              15    9605
XP_005276416                                                           15    9605
XP_005260215                                                           15    9605
XP_005260214                                                           15    9605
XP_005267096                                                           15    9605
XP_006715570                                                           15    9605
NP_003202                                                              15    9605
>NP_004295
          Length = 1620

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VVVKTLPEV 9
            V VKTLPEV
Sbjct: 1147 VAVKTLPEV 1155
>NP_996844
          Length = 803

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V +KTLPE+
Sbjct: 480 VAIKTLPEL 488
>XP_005254439
          Length = 475

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V +KTLPE+
Sbjct: 152 VAIKTLPEL 160
>XP_006720568
          Length = 771

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V +KTLPE+
Sbjct: 448 VAIKTLPEL 456
>XP_005254438
          Length = 819

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V +KTLPE+
Sbjct: 496 VAIKTLPEL 504
>NP_002335
          Length = 864

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V +KTLPE+
Sbjct: 541 VAIKTLPEL 549
>NP_001244211
          Length = 249

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VVVKTLPE 8
           VVVK LPE
Sbjct: 111 VVVKLLPE 118
>NP_078807
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKELPE 43
>NP_001240744
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKELPE 43
>NP_001240745
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKELPE 43
>NP_001244210
          Length = 603

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VVVKTLPE 8
           VVVK LPE
Sbjct: 111 VVVKLLPE 118
>NP_689596
          Length = 885

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VVVKTLPE 8
           VVVK LPE
Sbjct: 111 VVVKLLPE 118
>NP_001098047
          Length = 448

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKDLPE 43
>NP_060456
          Length = 448

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKDLPE 43
>XP_005256766
          Length = 350

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKDLPE 43
>XP_006716723
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKELPE 43
>XP_006716722
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKELPE 43
>XP_006716721
          Length = 445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  VVVKTLPE 8
          VVVK LPE
Sbjct: 36 VVVKELPE 43
>NP_000085
          Length = 2944

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VVVKTLPE 8
           VVV+T PE
Sbjct: 767 VVVRTAPE 774
>NP_780775
          Length = 1026

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKTLPEV 9
           VKT+PE+
Sbjct: 645 VKTVPEI 651
>NP_001230199
          Length = 1100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKTLPEV 9
           VKT+PE+
Sbjct: 719 VKTVPEI 725
>NP_055176
          Length = 1100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKTLPEV 9
           VKT+PE+
Sbjct: 719 VKTVPEI 725
>NP_001006635
          Length = 881

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V+ KTLPE+
Sbjct: 229 VLEKTLPEM 237
>NP_060524
          Length = 803

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V+ KTLPE+
Sbjct: 229 VLEKTLPEM 237
>NP_001230200
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VKTLPEV 9
           VKT+PE+
Sbjct: 719 VKTVPEI 725
>XP_006721123
          Length = 775

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V+ KTLPE+
Sbjct: 229 VLEKTLPEM 237
>XP_006721122
          Length = 804

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V+ KTLPE+
Sbjct: 152 VLEKTLPEM 160
>XP_005255471
          Length = 840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V+ KTLPE+
Sbjct: 229 VLEKTLPEM 237
>XP_006721121
          Length = 853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V+ KTLPE+
Sbjct: 229 VLEKTLPEM 237
>XP_005255470
          Length = 853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V+ KTLPE+
Sbjct: 229 VLEKTLPEM 237
>XP_006721120
          Length = 880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           V+ KTLPE+
Sbjct: 228 VLEKTLPEM 236
>NP_008986
          Length = 1390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VVVKTLPEV 9
            VVV+ +PEV
Sbjct: 1199 VVVQGIPEV 1207
>NP_056517
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           +V KTLP+V
Sbjct: 94  LVHKTLPDV 102
>NP_114409
          Length = 467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VVKTLPEV 9
           V KTLPE+
Sbjct: 206 VSKTLPEL 213
>NP_006865
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 373 VVIQTIPTV 381
>NP_001263388
          Length = 492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 332 VVIQTIPTV 340
>NP_001263387
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 361 VVIQTIPTV 369
>NP_001263386
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 344 VVIQTIPTV 352
>NP_071373
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VVVKTLP 7
           +V+KTLP
Sbjct: 278 LVIKTLP 284
>NP_973728
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 421 VVIQTIPTV 429
>NP_060382
          Length = 1022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KTLPEV 9
           KTLPE+
Sbjct: 374 KTLPEI 379
>NP_001158608
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KTLPEV 9
           KTLPE+
Sbjct: 374 KTLPEI 379
>XP_006717660
          Length = 1369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VVVKTLPEV 9
            VVV+ +PEV
Sbjct: 1178 VVVQGIPEV 1186
>XP_005266015
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VVVKTLP 7
           +V+KTLP
Sbjct: 278 LVIKTLP 284
>XP_005263140
          Length = 1034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   KTLPEV 9
           KTLPE+
Sbjct: 386 KTLPEI 391
>XP_006714193
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 354 VVIQTIPTV 362
>XP_005262863
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 317 VVIQTIPTV 325
>XP_006714192
          Length = 489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 329 VVIQTIPTV 337
>XP_005262862
          Length = 552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 392 VVIQTIPTV 400
>XP_006714191
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 404 VVIQTIPTV 412
>XP_005262861
          Length = 581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 421 VVIQTIPTV 429
>XP_005262860
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           VV++T+P V
Sbjct: 433 VVIQTIPTV 441
>NP_150597
          Length = 103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  VVKTLPE 8
          ++KTLP+
Sbjct: 76 IIKTLPQ 82
>NP_001128302
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVKTLPEV 9
           V+KT+P++
Sbjct: 129 VIKTVPQL 136
>NP_060121
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVKTLPEV 9
           V+KT+P++
Sbjct: 129 VIKTVPQL 136
>NP_001128303
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVKTLPEV 9
           V+KT+P++
Sbjct: 129 VIKTVPQL 136
>NP_001128304
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVKTLPEV 9
           V+KT+P++
Sbjct: 129 VIKTVPQL 136
>NP_997299
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VVKTLPEV 9
           V+KT PE+
Sbjct: 317 VLKTFPEM 324
>NP_001138669
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VVKTLPEV 9
           V+KT PE+
Sbjct: 317 VLKTFPEM 324
>NP_002514
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VVKTLPEV 9
           + KTLPE+
Sbjct: 240 IKKTLPEL 247
>NP_037422
          Length = 205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VVVKTLPEV 9
          VVVKTL ++
Sbjct: 46 VVVKTLEQL 54
>NP_001186125
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VVKTLPEV 9
          +VKT P+V
Sbjct: 72 IVKTAPKV 79
>NP_057640
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VVVKTLPEV 9
          VVVKTL ++
Sbjct: 46 VVVKTLEQL 54
>NP_219483
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VVKTLPEV 9
          +VKT P+V
Sbjct: 47 IVKTAPKV 54
>XP_005276416
          Length = 1583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VVKTLPEV 9
           V+KT PE+
Sbjct: 306 VLKTFPEM 313
>XP_005260215
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VVKTLPEV 9
          +VKT P+V
Sbjct: 47 IVKTAPKV 54
>XP_005260214
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  VVKTLPEV 9
          +VKT P+V
Sbjct: 47 IVKTAPKV 54
>XP_005267096
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVKTLPEV 9
           V+KT+P++
Sbjct: 129 VIKTVPQL 136
>XP_006715570
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VVKTLPEV 9
           V+KT+P++
Sbjct: 129 VIKTVPQL 136
>NP_003202
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VVVKTLPEV 9
           ++ KTLP++
Sbjct: 119 LLTKTLPDI 127
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.136    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 661,215
Number of extensions: 1057
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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