Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           20     390
NP_060785                                                              20     390
NP_361014                                                              20     390
NP_065871                                                              17    2528
XP_005260528                                                           17    2528
NP_079446                                                              17    3301
NP_079146                                                              17    3301
NP_065810                                                              17    3301
XP_006720684                                                           17    3301
NP_001007026                                                           17    4312
NP_004862                                                              17    4312
NP_671736                                                              17    4312
NP_004458                                                              17    4312
NP_001007025                                                           17    4312
NP_963847                                                              17    4312
NP_963846                                                              17    4312
NP_001013649                                                           17    4312
XP_006724707                                                           17    4312
XP_005258129                                                           17    4312
XP_005258128                                                           17    4312
XP_005258127                                                           17    4312
XP_005273507                                                           17    4312
NP_705898                                                              16    5631
NP_055747                                                              16    5631
XP_005247294                                                           16    5631
XP_005247293                                                           16    5631
XP_005247292                                                           16    5631
XP_005247291                                                           16    5631
XP_005247290                                                           16    5631
XP_006713603                                                           16    5631
XP_005247289                                                           16    5631
NP_001153468                                                           16    7355
NP_001153471                                                           16    7355
NP_001153467                                                           16    7355
NP_039254                                                              16    7355
NP_001153480                                                           16    7355
NP_039250                                                              16    7355
NP_001153473                                                           16    7355
NP_001153476                                                           16    7355
NP_039258                                                              16    7355
NP_039251                                                              16    7355
NP_004393                                                              16    7355
NP_001269598                                                           16    7355
NP_000499                                                              16    7355
NP_569732                                                              16    7355
NP_036303                                                              16    7355
NP_001127878                                                           16    7355
NP_001127877                                                           16    7355
NP_612147                                                              16    7355
XP_006716398                                                           16    7355
XP_005273544                                                           16    7355
XP_005273543                                                           16    7355
XP_005273542                                                           16    7355
XP_005250215                                                           16    7355
XP_005250214                                                           16    7355
XP_005250213                                                           16    7355
XP_005265933                                                           16    7355
NP_055820                                                              15    9605
NP_056270                                                              15    9605
XP_005267607                                                           15    9605
XP_006714963                                                           15    9605
XP_006714962                                                           15    9605
XP_005266010                                                           15    9605
NP_001135780                                                           15    9605
>NP_001013433
          Length = 589

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VSEYTSTAG 9
          VSEYTST G
Sbjct: 72 VSEYTSTTG 80
>NP_060785
          Length = 627

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEYTSTAG 9
           VSEYTST G
Sbjct: 110 VSEYTSTTG 118
>NP_361014
          Length = 707

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VSEYTSTAG 9
           VSEYTST G
Sbjct: 190 VSEYTSTTG 198
>NP_065871
          Length = 1659

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           V EY STAG
Sbjct: 856 VYEYVSTAG 864
>XP_005260528
          Length = 956

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           V EY STAG
Sbjct: 153 VYEYVSTAG 161
>NP_079446
          Length = 979

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           V EY STAG
Sbjct: 822 VYEYDSTAG 830
>NP_079146
          Length = 1606

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           V EY STAG
Sbjct: 822 VYEYDSTAG 830
>NP_065810
          Length = 4700

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSEYTSTAG 9
            VSE T TAG
Sbjct: 4090 VSELTDTAG 4098
>XP_006720684
          Length = 4713

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    VSEYTSTAG 9
            VSE T TAG
Sbjct: 4103 VSELTDTAG 4111
>NP_001007026
          Length = 248

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  VSEYTSTAG 9
          ++EYT++AG
Sbjct: 86 MAEYTNSAG 94
>NP_004862
          Length = 250

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  VSEYTSTAG 9
          ++EYT++AG
Sbjct: 88 MAEYTNSAG 96
>NP_671736
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           + EY+ TAG
Sbjct: 204 IGEYSGTAG 212
>NP_004458
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           + EY+ TAG
Sbjct: 204 IGEYSGTAG 212
>NP_001007025
          Length = 185

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  VSEYTSTAG 9
          ++EYT++AG
Sbjct: 23 MAEYTNSAG 31
>NP_963847
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           + EY+ TAG
Sbjct: 204 IGEYSGTAG 212
>NP_963846
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           + EY+ TAG
Sbjct: 204 IGEYSGTAG 212
>NP_001013649
          Length = 1225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VSEYTSTAG 9
            +SE T+TAG
Sbjct: 1153 ISESTATAG 1161
>XP_006724707
          Length = 1337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VSEYTSTAG 9
            +SE T+TAG
Sbjct: 1265 ISESTATAG 1273
>XP_005258129
          Length = 185

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  VSEYTSTAG 9
          ++EYT++AG
Sbjct: 23 MAEYTNSAG 31
>XP_005258128
          Length = 298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VSEYTSTAG 9
           ++EYT++AG
Sbjct: 136 MAEYTNSAG 144
>XP_005258127
          Length = 300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VSEYTSTAG 9
           ++EYT++AG
Sbjct: 138 MAEYTNSAG 146
>XP_005273507
          Length = 362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           + EY+ TAG
Sbjct: 254 IGEYSGTAG 262
>NP_705898
          Length = 564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  SEYTSTAG 9
          S Y STAG
Sbjct: 3  SRYNSTAG 10
>NP_055747
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VSEYTST 7
           +S+YTST
Sbjct: 619 ISQYTST 625
>XP_005247294
          Length = 671

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VSEYTST 7
           +S+YTST
Sbjct: 467 ISQYTST 473
>XP_005247293
          Length = 814

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VSEYTST 7
           +S+YTST
Sbjct: 610 ISQYTST 616
>XP_005247292
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VSEYTST 7
           +S+YTST
Sbjct: 619 ISQYTST 625
>XP_005247291
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VSEYTST 7
           +S+YTST
Sbjct: 619 ISQYTST 625
>XP_005247290
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VSEYTST 7
           +S+YTST
Sbjct: 630 ISQYTST 636
>XP_006713603
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VSEYTST 7
           +S+YTST
Sbjct: 639 ISQYTST 645
>XP_005247289
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VSEYTST 7
           +S+YTST
Sbjct: 639 ISQYTST 645
>NP_001153468
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 181 SHYTSTA 187
>NP_001153471
          Length = 624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 319 SHYTSTA 325
>NP_001153467
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 302 SHYTSTA 308
>NP_039254
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 335 SHYTSTA 341
>NP_001153480
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 332 SHYTSTA 338
>NP_039250
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 340 SHYTSTA 346
>NP_001153473
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 285 SHYTSTA 291
>NP_001153476
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 332 SHYTSTA 338
>NP_039258
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 335 SHYTSTA 341
>NP_039251
          Length = 637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 332 SHYTSTA 338
>NP_004393
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VSEYTSTAG 9
           VS Y ST G
Sbjct: 171 VSSYPSTVG 179
>NP_001269598
          Length = 362

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VSEYTSTAG 9
           VS Y ST G
Sbjct: 195 VSSYPSTVG 203
>NP_000499
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VSEYTSTAG 9
           VS Y  TAG
Sbjct: 755 VSSYEGTAG 763
>NP_569732
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           +SE  STAG
Sbjct: 286 ISEVLSTAG 294
>NP_036303
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           +SE  STAG
Sbjct: 289 ISEVLSTAG 297
>NP_001127878
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEYTSTA 8
           +SEY STA
Sbjct: 138 LSEYISTA 145
>NP_001127877
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEYTSTA 8
           +SEY STA
Sbjct: 138 LSEYISTA 145
>NP_612147
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEYTSTA 8
           +SEY STA
Sbjct: 155 LSEYISTA 162
>XP_006716398
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 115 SHYTSTA 121
>XP_005273544
          Length = 692

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 387 SHYTSTA 393
>XP_005273543
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 390 SHYTSTA 396
>XP_005273542
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   SEYTSTA 8
           S YTSTA
Sbjct: 395 SHYTSTA 401
>XP_005250215
          Length = 336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VSEYTSTA 8
          +SEY STA
Sbjct: 18 LSEYISTA 25
>XP_005250214
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VSEYTSTA 8
          +SEY STA
Sbjct: 24 LSEYISTA 31
>XP_005250213
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VSEYTSTA 8
           +SEY STA
Sbjct: 138 LSEYISTA 145
>XP_005265933
          Length = 263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VSEYTSTAG 9
           +SE  STAG
Sbjct: 220 ISEVLSTAG 228
>NP_055820
          Length = 1519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SEYTSTA 8
            S+YTST+
Sbjct: 1185 SDYTSTS 1191
>NP_056270
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VSEYTSTAG 9
           V EY ST G
Sbjct: 421 VVEYLSTGG 429
>XP_005267607
          Length = 1589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SEYTSTA 8
            S+YTST+
Sbjct: 1255 SDYTSTS 1261
>XP_006714963
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VSEYTSTAG 9
           V EY ST G
Sbjct: 416 VVEYLSTGG 424
>XP_006714962
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VSEYTSTAG 9
           V EY ST G
Sbjct: 421 VVEYLSTGG 429
>XP_005266010
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VSEYTSTAG 9
           V EY ST G
Sbjct: 421 VVEYLSTGG 429
>NP_001135780
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    SEYTSTAG 9
            + YTST G
Sbjct: 1720 AHYTSTTG 1727
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290    0.106    0.262 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 455,174
Number of extensions: 534
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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