Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              20     509
NP_006168                                                              18    1935
NP_003239                                                              18    1935
XP_006720217                                                           18    1935
XP_005267767                                                           18    1935
XP_005267766                                                           18    1935
XP_005267765                                                           18    1935
NP_036434                                                              17    4312
NP_055736                                                              17    4312
NP_001008701                                                           17    4312
NP_056051                                                              17    4312
XP_005259876                                                           17    4312
XP_006722752                                                           17    4312
XP_005259875                                                           17    4312
XP_006722751                                                           17    4312
XP_006714219                                                           17    4312
XP_006714218                                                           17    4312
XP_006714217                                                           17    4312
XP_006714216                                                           17    4312
XP_005270731                                                           17    4312
XP_005270730                                                           17    4312
XP_006710560                                                           17    4312
XP_006710559                                                           17    4312
XP_006710558                                                           17    4312
XP_006710557                                                           17    4312
XP_006710556                                                           17    4312
XP_006710555                                                           17    4312
XP_005270727                                                           17    4312
XP_006710554                                                           17    4312
XP_005270725                                                           17    4312
XP_005270724                                                           17    4312
XP_006710553                                                           17    4312
XP_005270723                                                           17    4312
XP_006710552                                                           17    4312
XP_006710551                                                           17    4312
XP_006710550                                                           17    4312
XP_006710549                                                           17    4312
XP_006710548                                                           17    4312
NP_001229242                                                           16    5631
NP_001193981                                                           16    5631
NP_062558                                                              16    5631
XP_006723346                                                           16    5631
XP_005259115                                                           16    5631
NP_115627                                                              16    7355
NP_001073339                                                           16    7355
NP_001073340                                                           16    7355
NP_817084                                                              16    7355
NP_065094                                                              16    7355
NP_071898                                                              16    7355
XP_005258287                                                           16    7355
XP_006722481                                                           16    7355
XP_005258286                                                           16    7355
XP_006722480                                                           16    7355
XP_005258284                                                           16    7355
XP_006718583                                                           16    7355
XP_006718582                                                           16    7355
NP_001034449                                                           16    7355
NP_742068                                                              15    9605
NP_055816                                                              15    9605
NP_055577                                                              15    9605
NP_001274427                                                           15    9605
NP_115671                                                              15    9605
NP_996996                                                              15    9605
NP_064568                                                              15    9605
NP_001234934                                                           15    9605
NP_001234931                                                           15    9605
NP_001234932                                                           15    9605
NP_001234933                                                           15    9605
XP_006719177                                                           15    9605
XP_006719176                                                           15    9605
XP_006719175                                                           15    9605
XP_005268498                                                           15    9605
XP_006711246                                                           15    9605
XP_005244978                                                           15    9605
XP_005244975                                                           15    9605
NP_056277                                                              15    9605
>NP_055365
          Length = 1032

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VRGLEAERN 9
           VRGLEAER+
Sbjct: 423 VRGLEAERD 431
>NP_006168
          Length = 237

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RGLEAER 8
           RGLEAER
Sbjct: 185 RGLEAER 191
>NP_003239
          Length = 961

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VRGLEAERN 9
           +RG +AERN
Sbjct: 415 IRGCKAERN 423
>XP_006720217
          Length = 132

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2  RGLEAER 8
          RGLEAER
Sbjct: 80 RGLEAER 86
>XP_005267767
          Length = 237

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RGLEAER 8
           RGLEAER
Sbjct: 185 RGLEAER 191
>XP_005267766
          Length = 237

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RGLEAER 8
           RGLEAER
Sbjct: 185 RGLEAER 191
>XP_005267765
          Length = 237

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RGLEAER 8
           RGLEAER
Sbjct: 185 RGLEAER 191
>NP_036434
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 860 RGLQSDRN 867
>NP_055736
          Length = 1469

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGLEAERN 9
           +RGL+ +RN
Sbjct: 880 LRGLQTDRN 888
>NP_001008701
          Length = 1474

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGLEAERN 9
           +RGL+ +RN
Sbjct: 885 LRGLQTDRN 893
>NP_056051
          Length = 1469

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 903 RGLQSDRN 910
>XP_005259876
          Length = 1498

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGLEAERN 9
           +RGL+ +RN
Sbjct: 885 LRGLQTDRN 893
>XP_006722752
          Length = 1462

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGLEAERN 9
           +RGL+ +RN
Sbjct: 849 LRGLQTDRN 857
>XP_005259875
          Length = 1493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGLEAERN 9
           +RGL+ +RN
Sbjct: 880 LRGLQTDRN 888
>XP_006722751
          Length = 1498

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRGLEAERN 9
           +RGL+ +RN
Sbjct: 885 LRGLQTDRN 893
>XP_006714219
          Length = 806

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 469 RGLQSDRN 476
>XP_006714218
          Length = 846

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 274 RGLQSDRN 281
>XP_006714217
          Length = 1013

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 456 RGLQSDRN 463
>XP_006714216
          Length = 1026

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 469 RGLQSDRN 476
>XP_005270731
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 860 RGLQSDRN 867
>XP_005270730
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 860 RGLQSDRN 867
>XP_006710560
          Length = 1181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710559
          Length = 1188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710558
          Length = 1191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710557
          Length = 1191

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710556
          Length = 1195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710555
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 860 RGLQSDRN 867
>XP_005270727
          Length = 1403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 860 RGLQSDRN 867
>XP_006710554
          Length = 1421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_005270725
          Length = 1446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 860 RGLQSDRN 867
>XP_005270724
          Length = 1446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 860 RGLQSDRN 867
>XP_006710553
          Length = 1451

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 865 RGLQSDRN 872
>XP_005270723
          Length = 1459

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 873 RGLQSDRN 880
>XP_006710552
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710551
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710550
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710549
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>XP_006710548
          Length = 1464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RGLEAERN 9
           RGL+++RN
Sbjct: 878 RGLQSDRN 885
>NP_001229242
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VRGLEAE 7
          +RGLEAE
Sbjct: 76 MRGLEAE 82
>NP_001193981
          Length = 347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VRGLEAE 7
          +RGLEAE
Sbjct: 76 MRGLEAE 82
>NP_062558
          Length = 463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VRGLEAE 7
          +RGLEAE
Sbjct: 74 LRGLEAE 80
>XP_006723346
          Length = 463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  VRGLEAE 7
          +RGLEAE
Sbjct: 74 LRGLEAE 80
>XP_005259115
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VRGLEAE 7
           +RGLEAE
Sbjct: 111 LRGLEAE 117
>NP_115627
          Length = 1476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VRGLEAE 7
           V+GLEAE
Sbjct: 288 VQGLEAE 294
>NP_001073339
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VRGLEAE 7
           VRG EAE
Sbjct: 464 VRGFEAE 470
>NP_001073340
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VRGLEAE 7
           VRG EAE
Sbjct: 456 VRGFEAE 462
>NP_817084
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VRGLEAE 7
           VRG EAE
Sbjct: 481 VRGFEAE 487
>NP_065094
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RGLEAERN 9
           RG++A RN
Sbjct: 266 RGVDANRN 273
>NP_071898
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAERN 9
           LEAERN
Sbjct: 254 LEAERN 259
>XP_005258287
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAERN 9
           LEAERN
Sbjct: 564 LEAERN 569
>XP_006722481
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAERN 9
           LEAERN
Sbjct: 564 LEAERN 569
>XP_005258286
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAERN 9
           LEAERN
Sbjct: 564 LEAERN 569
>XP_006722480
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAERN 9
           LEAERN
Sbjct: 564 LEAERN 569
>XP_005258284
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAERN 9
           LEAERN
Sbjct: 564 LEAERN 569
>XP_006718583
          Length = 1482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VRGLEAE 7
           V+GLEAE
Sbjct: 210 VQGLEAE 216
>XP_006718582
          Length = 1560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VRGLEAE 7
           V+GLEAE
Sbjct: 288 VQGLEAE 294
>NP_001034449
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LEAERN 9
           LEAERN
Sbjct: 564 LEAERN 569
>NP_742068
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VRGLEAERN 9
           +RGLEA  N
Sbjct: 983 LRGLEAVSN 991
>NP_055816
          Length = 3664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   VRGLEAERN 9
           VRG   ERN
Sbjct: 228 VRGRRPERN 236
>NP_055577
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VRGLEA 6
           VRGLEA
Sbjct: 245 VRGLEA 250
>NP_001274427
          Length = 478

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+EAE N
Sbjct: 238 GIEAEEN 244
>NP_115671
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+EAE N
Sbjct: 238 GIEAEEN 244
>NP_996996
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+EAE N
Sbjct: 238 GIEAEEN 244
>NP_064568
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+E ERN
Sbjct: 329 GMEEERN 335
>NP_001234934
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+E ERN
Sbjct: 292 GMEEERN 298
>NP_001234931
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+E ERN
Sbjct: 315 GMEEERN 321
>NP_001234932
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+E ERN
Sbjct: 292 GMEEERN 298
>NP_001234933
          Length = 588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+E ERN
Sbjct: 281 GMEEERN 287
>XP_006719177
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+E ERN
Sbjct: 207 GMEEERN 213
>XP_006719176
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+E ERN
Sbjct: 227 GMEEERN 233
>XP_006719175
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GLEAERN 9
           G+E ERN
Sbjct: 326 GMEEERN 332
>XP_005268498
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VRGLEA 6
           VRGLEA
Sbjct: 445 VRGLEA 450
>XP_006711246
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VRGLEAERN 9
           +RGLEA  N
Sbjct: 983 LRGLEAVSN 991
>XP_005244978
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VRGLEAERN 9
           +RGLEA  N
Sbjct: 962 LRGLEAVSN 970
>XP_005244975
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VRGLEAERN 9
           +RGLEA  N
Sbjct: 983 LRGLEAVSN 991
>NP_056277
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   VRGLEA 6
           VRGLEA
Sbjct: 129 VRGLEA 134
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.133    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 507,564
Number of extensions: 907
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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