Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     869
NP_001263689                                                           19     869
NP_001119584                                                           19     869
NP_001119586                                                           19     869
NP_001263625                                                           19     869
NP_001119590                                                           19     869
NP_001263690                                                           19     869
NP_001119585                                                           19     869
NP_001263624                                                           19     869
NP_001119588                                                           19     869
NP_001119587                                                           19     869
NP_001119589                                                           19     869
NP_001230133                                                           17    3301
NP_001135936                                                           17    3301
NP_057665                                                              17    3301
NP_055178                                                              16    5631
NP_001263627                                                           16    5631
NP_001263628                                                           16    5631
NP_001264984                                                           16    5631
NP_001263626                                                           16    5631
XP_005266395                                                           16    5631
NP_060021                                                              16    7355
NP_112181                                                              16    7355
NP_001004753                                                           16    7355
XP_006717867                                                           16    7355
NP_055483                                                              15    9605
NP_001626                                                              15    9605
NP_647477                                                              15    9605
XP_006715753                                                           15    9605
XP_006715752                                                           15    9605
XP_005246254                                                           15    9605
XP_005246253                                                           15    9605
XP_005246252                                                           15    9605
XP_006711970                                                           15    9605
XP_006711969                                                           15    9605
XP_005246249                                                           15    9605
XP_006711968                                                           15    9605
XP_006711967                                                           15    9605
NP_671709                                                              15    9605
>NP_000537
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 157 VRAMAIYKQ 165
>NP_001263689
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001119584
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 157 VRAMAIYKQ 165
>NP_001119586
          Length = 341

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 157 VRAMAIYKQ 165
>NP_001263625
          Length = 302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001119590
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001263690
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001119585
          Length = 346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 157 VRAMAIYKQ 165
>NP_001263624
          Length = 307

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VR MAIYKQ
Sbjct: 118 VRAMAIYKQ 126
>NP_001119588
          Length = 209

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRDMAIYKQ 9
          VR MAIYKQ
Sbjct: 25 VRAMAIYKQ 33
>NP_001119587
          Length = 261

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRDMAIYKQ 9
          VR MAIYKQ
Sbjct: 25 VRAMAIYKQ 33
>NP_001119589
          Length = 214

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  VRDMAIYKQ 9
          VR MAIYKQ
Sbjct: 25 VRAMAIYKQ 33
>NP_001230133
          Length = 296

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDMAIYKQ 9
           RD+A+Y Q
Sbjct: 124 RDLAVYNQ 131
>NP_001135936
          Length = 296

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDMAIYKQ 9
           RD+A+Y Q
Sbjct: 124 RDLAVYNQ 131
>NP_057665
          Length = 431

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDMAIYKQ 9
           RD+A+Y Q
Sbjct: 124 RDLAVYNQ 131
>NP_055178
          Length = 4579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    VRDMAIY 7
            VRD+A+Y
Sbjct: 3902 VRDLALY 3908
>NP_001263627
          Length = 182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 MAIYKQ 9
         MAIYKQ
Sbjct: 1 MAIYKQ 6
>NP_001263628
          Length = 187

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 MAIYKQ 9
         MAIYKQ
Sbjct: 1 MAIYKQ 6
>NP_001264984
          Length = 4432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    VRDMAIY 7
            VRD+A+Y
Sbjct: 3755 VRDLALY 3761
>NP_001263626
          Length = 234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 MAIYKQ 9
         MAIYKQ
Sbjct: 1 MAIYKQ 6
>XP_005266395
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    VRDMAIY 7
            VRD+A+Y
Sbjct: 3911 VRDLALY 3917
>NP_060021
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VRDMAIYK 8
           VRD A+Y+
Sbjct: 682 VRDSAVYE 689
>NP_112181
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VRDMAIY 7
           VRD+A+Y
Sbjct: 605 VRDVALY 611
>NP_001004753
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VRDMAIYK 8
           +RD AIY+
Sbjct: 335 IRDKAIYE 342
>XP_006717867
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VRDMAIYK 8
           VRD A+Y+
Sbjct: 682 VRDSAVYE 689
>NP_055483
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DMAIYKQ 9
            +MAIYK+
Sbjct: 1580 EMAIYKK 1586
>NP_001626
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDMAIYK 8
           RD+A YK
Sbjct: 677 RDLATYK 683
>NP_647477
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDMAIYK 8
           RD+A YK
Sbjct: 635 RDLATYK 641
>XP_006715753
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDMAIYK 8
           RD+A YK
Sbjct: 801 RDLATYK 807
>XP_006715752
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    RDMAIYK 8
            RD+A YK
Sbjct: 1207 RDLATYK 1213
>XP_005246254
          Length = 947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DMAIYKQ 9
           +MAIYK+
Sbjct: 578 EMAIYKK 584
>XP_005246253
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DMAIYKQ 9
           +MAIYK+
Sbjct: 669 EMAIYKK 675
>XP_005246252
          Length = 1850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DMAIYKQ 9
            +MAIYK+
Sbjct: 1481 EMAIYKK 1487
>XP_006711970
          Length = 1948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DMAIYKQ 9
            +MAIYK+
Sbjct: 1579 EMAIYKK 1585
>XP_006711969
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DMAIYKQ 9
            +MAIYK+
Sbjct: 1580 EMAIYKK 1586
>XP_005246249
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DMAIYKQ 9
            +MAIYK+
Sbjct: 1580 EMAIYKK 1586
>XP_006711968
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DMAIYKQ 9
            +MAIYK+
Sbjct: 1580 EMAIYKK 1586
>XP_006711967
          Length = 1949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    DMAIYKQ 9
            +MAIYK+
Sbjct: 1580 EMAIYKK 1586
>NP_671709
          Length = 173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VRDMAIYKQ 9
           VRD+ I+K+
Sbjct: 160 VRDLEIHKK 168
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.138    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 423,941
Number of extensions: 716
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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