Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              17    2528
NP_653080                                                              17    2528
XP_005267292                                                           17    2528
XP_005267291                                                           17    2528
XP_005267290                                                           17    2528
NP_997275                                                              17    3301
NP_001231776                                                           17    3301
NP_004097                                                              16    5631
NP_057336                                                              16    7355
NP_525022                                                              16    7355
NP_001275915                                                           16    7355
NP_001275914                                                           16    7355
NP_009099                                                              16    7355
NP_525021                                                              16    7355
XP_005256997                                                           16    7355
XP_005256995                                                           16    7355
XP_005256993                                                           16    7355
XP_005256992                                                           16    7355
XP_006721697                                                           16    7355
XP_006721696                                                           16    7355
XP_005256991                                                           16    7355
XP_005266922                                                           16    7355
XP_006712120                                                           16    7355
XP_005264512                                                           16    7355
XP_005264511                                                           16    7355
XP_006712119                                                           16    7355
XP_005264510                                                           16    7355
XP_006712118                                                           16    7355
XP_005264509                                                           16    7355
XP_005264508                                                           16    7355
XP_006712117                                                           16    7355
XP_005264507                                                           16    7355
XP_005264506                                                           16    7355
NP_001025029                                                           16    7355
NP_001013712                                                           15    9605
XP_005268927                                                           15    9605
>NP_005091
          Length = 1782

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPAVVLLSE 9
           VPAVV LSE
Sbjct: 843 VPAVVPLSE 851
>NP_653080
          Length = 1684

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPAVVLLSE 9
           VPAVV LSE
Sbjct: 745 VPAVVPLSE 753
>XP_005267292
          Length = 1677

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPAVVLLSE 9
           VPAVV LSE
Sbjct: 738 VPAVVPLSE 746
>XP_005267291
          Length = 1684

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPAVVLLSE 9
           VPAVV LSE
Sbjct: 745 VPAVVPLSE 753
>XP_005267290
          Length = 1782

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VPAVVLLSE 9
           VPAVV LSE
Sbjct: 843 VPAVVPLSE 851
>NP_997275
          Length = 99

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  VPAVVLLS 8
          +PAVVLLS
Sbjct: 6  LPAVVLLS 13
>NP_001231776
          Length = 85

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  VPAVVLLS 8
          +PAVVLLS
Sbjct: 6  LPAVVLLS 13
>NP_004097
          Length = 86

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1 VPAVVLL 7
         +PAVVLL
Sbjct: 2 IPAVVLL 8
>NP_057336
          Length = 4857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3214 LPAAVLLKE 3222
>NP_525022
          Length = 1624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1439 PSVVLLDE 1446
>NP_001275915
          Length = 1616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1431 PSVVLLDE 1438
>NP_001275914
          Length = 1621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1436 PSVVLLDE 1443
>NP_009099
          Length = 1581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1396 PSVVLLDE 1403
>NP_525021
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1358 PSVVLLDE 1365
>XP_005256997
          Length = 1560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1375 PSVVLLDE 1382
>XP_005256995
          Length = 1621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1436 PSVVLLDE 1443
>XP_005256993
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1358 PSVVLLDE 1365
>XP_005256992
          Length = 1543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1358 PSVVLLDE 1365
>XP_006721697
          Length = 1625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1447 PSVVLLDE 1454
>XP_006721696
          Length = 1632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1447 PSVVLLDE 1454
>XP_005256991
          Length = 1632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    PAVVLLSE 9
            P+VVLL E
Sbjct: 1447 PSVVLLDE 1454
>XP_005266922
          Length = 408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VPAVVLLS 8
           +P V+LLS
Sbjct: 166 IPVVILLS 173
>XP_006712120
          Length = 4812

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3169 LPAAVLLKE 3177
>XP_005264512
          Length = 4840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3197 LPAAVLLKE 3205
>XP_005264511
          Length = 4847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3241 LPAAVLLKE 3249
>XP_006712119
          Length = 4851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3208 LPAAVLLKE 3216
>XP_005264510
          Length = 4861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3218 LPAAVLLKE 3226
>XP_006712118
          Length = 4864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3241 LPAAVLLKE 3249
>XP_005264509
          Length = 4870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3227 LPAAVLLKE 3235
>XP_005264508
          Length = 4875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3232 LPAAVLLKE 3240
>XP_006712117
          Length = 4878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3235 LPAAVLLKE 3243
>XP_005264507
          Length = 4880

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3237 LPAAVLLKE 3245
>XP_005264506
          Length = 4884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VPAVVLLSE 9
            +PA VLL E
Sbjct: 3241 LPAAVLLKE 3249
>NP_001025029
          Length = 408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VPAVVLLS 8
           +P V+LLS
Sbjct: 166 IPVVILLS 173
>NP_001013712
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PAVVLLSE 9
           P+V+L+SE
Sbjct: 485 PSVLLISE 492
>XP_005268927
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PAVVLLSE 9
           P+V+L+SE
Sbjct: 485 PSVLLISE 492
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.135    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 481,502
Number of extensions: 613
Number of successful extensions: 36
Number of sequences better than 10000.0: 36
Number of HSP's gapped: 36
Number of HSP's successfully gapped: 36
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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