Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              20     299
NP_001036064                                                           19     869
NP_005226                                                              19     869
XP_005246434                                                           19     869
XP_005246433                                                           19     869
XP_005246432                                                           19     869
XP_006712427                                                           19     869
NP_001276866                                                           17    2528
NP_004439                                                              17    2528
NP_001276865                                                           17    2528
NP_001005862                                                           17    2528
NP_005384                                                              17    2528
NP_001156729                                                           17    2528
XP_005257197                                                           17    2528
XP_006721828                                                           17    2528
NP_001094                                                              17    3301
NP_001265272                                                           17    3301
NP_060570                                                              17    3301
NP_001165891                                                           17    3301
NP_072097                                                              17    4312
NP_001258625                                                           16    5631
NP_001258627                                                           16    5631
NP_004290                                                              16    5631
NP_001258628                                                           16    5631
NP_001258626                                                           16    5631
NP_001138870                                                           16    5631
NP_003207                                                              16    5631
NP_001277251                                                           16    7355
NP_005500                                                              16    7355
NP_001277250                                                           16    7355
NP_851853                                                              16    7355
XP_005271970                                                           16    7355
XP_005271969                                                           16    7355
XP_005271967                                                           16    7355
XP_005271966                                                           16    7355
NP_001259004                                                           15    9605
NP_005144                                                              15    9605
NP_001228                                                              15    9605
NP_057427                                                              15    9605
NP_055970                                                              15    9605
NP_061027                                                              15    9605
NP_714921                                                              15    9605
XP_006721395                                                           15    9605
XP_006721394                                                           15    9605
XP_006721393                                                           15    9605
XP_006717499                                                           15    9605
XP_005252492                                                           15    9605
XP_005252490                                                           15    9605
XP_005252489                                                           15    9605
XP_005252488                                                           15    9605
>NP_005219
          Length = 1210

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            V+DADEYLI
Sbjct: 1010 VVDADEYLI 1018
>NP_001036064
          Length = 1292

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            +MDA+EYL+
Sbjct: 1016 MMDAEEYLV 1024
>NP_005226
          Length = 1308

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            +MDA+EYL+
Sbjct: 1016 MMDAEEYLV 1024
>XP_005246434
          Length = 1282

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            +MDA+EYL+
Sbjct: 1006 MMDAEEYLV 1014
>XP_005246433
          Length = 1298

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            +MDA+EYL+
Sbjct: 1006 MMDAEEYLV 1014
>XP_005246432
          Length = 1307

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            +MDA+EYL+
Sbjct: 1031 MMDAEEYLV 1039
>XP_006712427
          Length = 1323

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            +MDA+EYL+
Sbjct: 1031 MMDAEEYLV 1039
>NP_001276866
          Length = 1055

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            ++DA+EYL+
Sbjct: 1017 LVDAEEYLV 1025
>NP_004439
          Length = 1255

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            ++DA+EYL+
Sbjct: 1017 LVDAEEYLV 1025
>NP_001276865
          Length = 1240

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            ++DA+EYL+
Sbjct: 1002 LVDAEEYLV 1010
>NP_001005862
          Length = 1225

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VMDADEYLI 9
           ++DA+EYL+
Sbjct: 987 LVDAEEYLV 995
>NP_005384
          Length = 1909

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMDADEY 7
           ++DADEY
Sbjct: 553 ILDADEY 559
>NP_001156729
          Length = 1932

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VMDADEY 7
           ++DADEY
Sbjct: 576 ILDADEY 582
>XP_005257197
          Length = 1225

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VMDADEYLI 9
           ++DA+EYL+
Sbjct: 987 LVDAEEYLV 995
>XP_006721828
          Length = 1336

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    VMDADEYLI 9
            ++DA+EYL+
Sbjct: 1098 LVDAEEYLV 1106
>NP_001094
          Length = 894

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VMDADEYLI 9
          V D DEY+I
Sbjct: 13 VYDEDEYMI 21
>NP_001265272
          Length = 894

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VMDADEYLI 9
          V D DEY+I
Sbjct: 13 VYDEDEYMI 21
>NP_060570
          Length = 640

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VMDADEYLI 9
           ++D DEY++
Sbjct: 505 ILDTDEYVL 513
>NP_001165891
          Length = 621

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VMDADEYLI 9
           ++D DEY++
Sbjct: 486 ILDTDEYVL 494
>NP_072097
          Length = 839

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VMDADEYLI 9
           V+D D YL+
Sbjct: 302 VLDEDSYLV 310
>NP_001258625
          Length = 752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VMDADEYLI 9
           V+DADE ++
Sbjct: 670 VVDADEIIV 678
>NP_001258627
          Length = 726

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VMDADEYLI 9
           V+DADE ++
Sbjct: 644 VVDADEIIV 652
>NP_004290
          Length = 753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VMDADEYLI 9
           V+DADE ++
Sbjct: 671 VVDADEIIV 679
>NP_001258628
          Length = 713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VMDADEYLI 9
           V+DADE ++
Sbjct: 631 VVDADEIIV 639
>NP_001258626
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VMDADEYLI 9
           V+DADE ++
Sbjct: 630 VVDADEIIV 638
>NP_001138870
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  MDADEYLI 9
          MD DE+L+
Sbjct: 69 MDLDEFLL 76
>NP_003207
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MDADEYLI 9
           MD DE+L+
Sbjct: 99  MDLDEFLL 106
>NP_001277251
          Length = 2854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VMDADEYL 8
            ++DAD YL
Sbjct: 2631 IVDADGYL 2638
>NP_005500
          Length = 3027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VMDADEYL 8
            ++DAD YL
Sbjct: 2804 IVDADGYL 2811
>NP_001277250
          Length = 3048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VMDADEYL 8
            ++DAD YL
Sbjct: 2825 IVDADGYL 2832
>NP_851853
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VMDADEYL 8
           VM+A EY+
Sbjct: 302 VMEAQEYI 309
>XP_005271970
          Length = 2931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VMDADEYL 8
            ++DAD YL
Sbjct: 2863 IVDADGYL 2870
>XP_005271969
          Length = 3020

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VMDADEYL 8
            ++DAD YL
Sbjct: 2797 IVDADGYL 2804
>XP_005271967
          Length = 3065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VMDADEYL 8
            ++DAD YL
Sbjct: 2842 IVDADGYL 2849
>XP_005271966
          Length = 3086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VMDADEYL 8
            ++DAD YL
Sbjct: 2863 IVDADGYL 2870
>NP_001259004
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DADEYL 8
           DA+EYL
Sbjct: 527 DAEEYL 532
>NP_005144
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DADEYL 8
           DA+EYL
Sbjct: 523 DAEEYL 528
>NP_001228
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VMDADEYL 8
           ++DAD YL
Sbjct: 341 LIDADPYL 348
>NP_057427
          Length = 3114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    DADEYL 8
            +ADEYL
Sbjct: 2856 EADEYL 2861
>NP_055970
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   MDADEYL 8
           MD+D+Y+
Sbjct: 183 MDSDQYV 189
>NP_061027
          Length = 4599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   ADEYLI 9
           ADEY+I
Sbjct: 545 ADEYMI 550
>NP_714921
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VMDADEYL 8
           V+DA EYL
Sbjct: 141 VLDALEYL 148
>XP_006721395
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DADEYL 8
           DA+EYL
Sbjct: 327 DAEEYL 332
>XP_006721394
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DADEYL 8
           DA+EYL
Sbjct: 528 DAEEYL 533
>XP_006721393
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DADEYL 8
           DA+EYL
Sbjct: 528 DAEEYL 533
>XP_006717499
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  MDADEYL 8
          MD+D+Y+
Sbjct: 26 MDSDQYV 32
>XP_005252492
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  MDADEYL 8
          MD+D+Y+
Sbjct: 60 MDSDQYV 66
>XP_005252490
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   MDADEYL 8
           MD+D+Y+
Sbjct: 206 MDSDQYV 212
>XP_005252489
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   MDADEYL 8
           MD+D+Y+
Sbjct: 183 MDSDQYV 189
>XP_005252488
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   MDADEYL 8
           MD+D+Y+
Sbjct: 206 MDSDQYV 212
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.144    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 635,250
Number of extensions: 1283
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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