Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              17    2528
XP_006716142                                                           17    2528
XP_005250088                                                           17    2528
XP_006716141                                                           17    2528
XP_005250085                                                           17    2528
XP_006716140                                                           17    2528
XP_005250084                                                           17    2528
XP_005250083                                                           17    2528
XP_005250082                                                           17    2528
NP_002902                                                              17    4312
XP_005260072                                                           17    4312
NP_789792                                                              16    5631
XP_006718281                                                           16    5631
NP_001135906                                                           16    7355
NP_036347                                                              16    7355
NP_940912                                                              15    9605

>NP_733751
          Length = 4911

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2917 VLSSLLANE 2925



>XP_006716142
          Length = 4927

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2934 VLSSLLANE 2942



>XP_005250088
          Length = 4928

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2934 VLSSLLANE 2942



>XP_006716141
          Length = 4959

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2934 VLSSLLANE 2942



>XP_005250085
          Length = 4979

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2934 VLSSLLANE 2942



>XP_006716140
          Length = 4982

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2934 VLSSLLANE 2942



>XP_005250084
          Length = 4982

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2934 VLSSLLANE 2942



>XP_005250083
          Length = 4982

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2933 VLSSLLANE 2941



>XP_005250082
          Length = 4983

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VLSSLRANE 9
            VLSSL ANE
Sbjct: 2934 VLSSLLANE 2942



>NP_002902
          Length = 1118

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLSSLRANE 9
           +LS +RANE
Sbjct: 838 ILSCVRANE 846



>XP_005260072
          Length = 1129

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLSSLRANE 9
           +LS +RANE
Sbjct: 849 ILSCVRANE 857



>NP_789792
          Length = 1093

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLSSLRANE 9
           V SSL++NE
Sbjct: 352 VFSSLKSNE 360



>XP_006718281
          Length = 983

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLSSLRANE 9
           V SSL++NE
Sbjct: 242 VFSSLKSNE 250



>NP_001135906
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VLSSLRAN 8
           +LSSL+AN
Sbjct: 811 LLSSLKAN 818



>NP_036347
          Length = 916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   VLSSLRAN 8
           +LSSL+AN
Sbjct: 864 LLSSLKAN 871



>NP_940912
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLSSLRANE 9
           +LS L+AN+
Sbjct: 309 ILSDLQAND 317



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.305    0.118    0.266 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 262,334
Number of extensions: 286
Number of successful extensions: 16
Number of sequences better than 10000.0: 16
Number of HSP's gapped: 16
Number of HSP's successfully gapped: 16
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)