Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718908                                                           20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_055722                                                              19     869
NP_001192244                                                           18    1935
NP_078912                                                              18    1935
NP_001273206                                                           17    4312
NP_001273207                                                           17    4312
NP_001273208                                                           17    4312
NP_006313                                                              17    4312
XP_005268350                                                           17    4312
NP_001092010                                                           16    5631
NP_001159970                                                           16    5631
NP_006656                                                              16    5631
NP_060083                                                              16    5631
NP_001073936                                                           16    5631
XP_005254804                                                           16    5631
XP_006720791                                                           16    5631
XP_005254803                                                           16    5631
XP_005254800                                                           16    5631
XP_005254799                                                           16    5631
NP_003913                                                              16    5631
NP_112506                                                              16    7355
NP_006453                                                              16    7355
NP_056175                                                              16    7355
NP_060321                                                              16    7355
XP_005260703                                                           16    7355
XP_005260702                                                           16    7355
XP_006720655                                                           16    7355
XP_006720654                                                           16    7355
XP_006720653                                                           16    7355
XP_006720652                                                           16    7355
XP_005254573                                                           16    7355
NP_065840                                                              16    7355
NP_001128522                                                           16    7355
NP_000283                                                              15    9605
NP_001230115                                                           15    9605
NP_002639                                                              15    9605
NP_060338                                                              15    9605
NP_001001852                                                           15    9605
NP_001348                                                              15    9605
NP_001193968                                                           15    9605
NP_001193965                                                           15    9605
NP_001116295                                                           15    9605
NP_037402                                                              15    9605
NP_001075019                                                           15    9605
NP_954863                                                              15    9605
XP_006724836                                                           15    9605
XP_005262507                                                           15    9605
XP_006724835                                                           15    9605
XP_006724834                                                           15    9605
XP_006724833                                                           15    9605
XP_006724832                                                           15    9605
XP_006724831                                                           15    9605
XP_006724830                                                           15    9605
XP_005262504                                                           15    9605
XP_006724561                                                           15    9605
XP_005274607                                                           15    9605
XP_005274605                                                           15    9605
XP_006724560                                                           15    9605
XP_006724559                                                           15    9605
XP_005271664                                                           15    9605
XP_006718929                                                           15    9605
XP_005271663                                                           15    9605
XP_005271662                                                           15    9605
XP_005271661                                                           15    9605
XP_005271660                                                           15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLRDVIYT 8
            VLRDVIYT
Sbjct: 1464 VLRDVIYT 1471
>XP_006718908
          Length = 1708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   VLRDVIYT 8
           VLRDVIYT
Sbjct: 116 VLRDVIYT 123
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLRDVIYT 8
            VLRDVIYT
Sbjct: 1116 VLRDVIYT 1123
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLRDVIYT 8
            VLRDVIYT
Sbjct: 1458 VLRDVIYT 1465
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLRDVIYT 8
            VLRDVIYT
Sbjct: 1464 VLRDVIYT 1471
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLRDVIYT 8
            VLRDVIYT
Sbjct: 1464 VLRDVIYT 1471
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    VLRDVIYT 8
            VLRDVIYT
Sbjct: 1464 VLRDVIYT 1471
>NP_055722
          Length = 1578

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LRDVIYTF 9
            LRDV+YT+
Sbjct: 1524 LRDVVYTY 1531
>NP_001192244
          Length = 459

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           V+RDVIY +
Sbjct: 219 VIRDVIYPY 227
>NP_078912
          Length = 459

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           V+RDVIY +
Sbjct: 219 VIRDVIYPY 227
>NP_001273206
          Length = 897

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           ++RD++Y F
Sbjct: 240 LVRDILYVF 248
>NP_001273207
          Length = 824

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           ++RD++Y F
Sbjct: 250 LVRDILYVF 258
>NP_001273208
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           ++RD++Y F
Sbjct: 250 LVRDILYVF 258
>NP_006313
          Length = 907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           ++RD++Y F
Sbjct: 250 LVRDILYVF 258
>XP_005268350
          Length = 818

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           ++RD++Y F
Sbjct: 250 LVRDILYVF 258
>NP_001092010
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DVIYTF 9
           DV+YTF
Sbjct: 171 DVLYTF 176
>NP_001159970
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DVIYTF 9
           DV+YTF
Sbjct: 171 DVLYTF 176
>NP_006656
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   DVIYTF 9
           DV+YTF
Sbjct: 171 DVLYTF 176
>NP_060083
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VLRDVIYTF 9
           VLRD IY +
Sbjct: 556 VLRDYIYNW 564
>NP_001073936
          Length = 1848

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RDVIYTF 9
           +DVIYT+
Sbjct: 121 QDVIYTY 127
>XP_005254804
          Length = 4796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRDVIY 7
           LRDVIY
Sbjct: 985 LRDVIY 990
>XP_006720791
          Length = 4853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LRDVIY 7
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>XP_005254803
          Length = 4854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LRDVIY 7
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>XP_005254800
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LRDVIY 7
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>XP_005254799
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LRDVIY 7
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>NP_003913
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    LRDVIY 7
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>NP_112506
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           VLR+ ++TF
Sbjct: 296 VLRECLHTF 304
>NP_006453
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           VLR+ ++TF
Sbjct: 254 VLRECLHTF 262
>NP_056175
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRDVIYTF 9
           L DV+YT+
Sbjct: 966 LMDVVYTW 973
>NP_060321
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDVIYTF 9
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_005260703
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           VLR+ ++TF
Sbjct: 313 VLRECLHTF 321
>XP_005260702
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           VLR+ ++TF
Sbjct: 313 VLRECLHTF 321
>XP_006720655
          Length = 304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDVIYTF 9
           RD+IY F
Sbjct: 126 RDLIYAF 132
>XP_006720654
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDVIYTF 9
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_006720653
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDVIYTF 9
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_006720652
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDVIYTF 9
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_005254573
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDVIYTF 9
           RD+IY F
Sbjct: 145 RDLIYAF 151
>NP_065840
          Length = 1163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           +++DV+Y F
Sbjct: 670 LIKDVLYEF 678
>NP_001128522
          Length = 1179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           +++DV+Y F
Sbjct: 686 LIKDVLYEF 694
>NP_000283
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           V+R+ I+TF
Sbjct: 512 VIRNQIFTF 520
>NP_001230115
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           +L+D +YT
Sbjct: 283 LLKDTVYT 290
>NP_002639
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           +L+D +YT
Sbjct: 192 LLKDTVYT 199
>NP_060338
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           + R+VIYT
Sbjct: 491 LFREVIYT 498
>NP_001001852
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           +L+D +YT
Sbjct: 195 LLKDTVYT 202
>NP_001348
          Length = 1270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLRDVIYTF 9
           VLRDV+  +
Sbjct: 526 VLRDVVQAY 534
>NP_001193968
          Length = 262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LRDVIY 7
          LRDV+Y
Sbjct: 47 LRDVLY 52
>NP_001193965
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LRDVIY 7
          LRDV+Y
Sbjct: 47 LRDVLY 52
>NP_001116295
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LRDVIYTF 9
           LRD +Y F
Sbjct: 395 LRDSVYIF 402
>NP_037402
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           + RDVIY+
Sbjct: 156 IWRDVIYS 163
>NP_001075019
          Length = 1593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>NP_954863
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VLRDVIYTF 9
           +L DVIY F
Sbjct: 152 LLVDVIYIF 160
>XP_006724836
          Length = 1582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VLRDVIYT 8
           V  D+IYT
Sbjct: 960 VFSDIIYT 967
>XP_005262507
          Length = 1594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>XP_006724835
          Length = 1615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>XP_006724834
          Length = 1615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>XP_006724833
          Length = 1620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>XP_006724832
          Length = 1640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>XP_006724831
          Length = 1640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>XP_006724830
          Length = 1642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>XP_005262504
          Length = 1642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    VLRDVIYT 8
            V  D+IYT
Sbjct: 1020 VFSDIIYT 1027
>XP_006724561
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           V+R+ I+TF
Sbjct: 330 VIRNQIFTF 338
>XP_005274607
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           V+R+ I+TF
Sbjct: 512 VIRNQIFTF 520
>XP_005274605
          Length = 1217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           V+R+ I+TF
Sbjct: 512 VIRNQIFTF 520
>XP_006724560
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           V+R+ I+TF
Sbjct: 512 VIRNQIFTF 520
>XP_006724559
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLRDVIYTF 9
           V+R+ I+TF
Sbjct: 512 VIRNQIFTF 520
>XP_005271664
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           + R+VIYT
Sbjct: 491 LFREVIYT 498
>XP_006718929
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           + R+VIYT
Sbjct: 491 LFREVIYT 498
>XP_005271663
          Length = 774

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           + R+VIYT
Sbjct: 491 LFREVIYT 498
>XP_005271662
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           + R+VIYT
Sbjct: 491 LFREVIYT 498
>XP_005271661
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           + R+VIYT
Sbjct: 491 LFREVIYT 498
>XP_005271660
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLRDVIYT 8
           + R+VIYT
Sbjct: 491 LFREVIYT 498
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.346    0.161    0.473 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 489,574
Number of extensions: 807
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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