Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000446                                                              16    5631
NP_003480                                                              16    5631
XP_006724117                                                           16    5631
XP_005261123                                                           16    5631
XP_005261122                                                           16    5631
XP_005261120                                                           16    5631
XP_005259675                                                           16    5631
XP_005259674                                                           16    5631
NP_001611                                                              16    7355
NP_001265506                                                           16    7355
NP_001265507                                                           16    7355
NP_001265505                                                           16    7355
NP_001265504                                                           16    7355
NP_775864                                                              16    7355
NP_001192202                                                           16    7355
XP_006718751                                                           16    7355
XP_006718750                                                           16    7355
XP_005274303                                                           16    7355
XP_006718749                                                           16    7355
XP_005274302                                                           16    7355
XP_005274301                                                           16    7355
XP_005274300                                                           16    7355
XP_005274299                                                           16    7355
XP_005274298                                                           16    7355
XP_005274297                                                           16    7355
NP_114171                                                              16    7355
NP_061881                                                              16    7355
NP_006556                                                              15    9605
NP_055453                                                              15    9605
NP_057698                                                              15    9605
NP_055178                                                              15    9605
NP_001264984                                                           15    9605
NP_001275918                                                           15    9605
NP_001159451                                                           15    9605
NP_057425                                                              15    9605
NP_079527                                                              15    9605
NP_055871                                                              15    9605
XP_006725014                                                           15    9605
XP_006725013                                                           15    9605
XP_006725012                                                           15    9605
XP_005255832                                                           15    9605
XP_005266395                                                           15    9605
XP_006717953                                                           15    9605
XP_006717952                                                           15    9605
XP_006717951                                                           15    9605
XP_006717950                                                           15    9605
XP_006717949                                                           15    9605
XP_006717948                                                           15    9605
XP_006716724                                                           15    9605
XP_006711118                                                           15    9605
XP_006711117                                                           15    9605
>NP_000446
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLKKSKLR 9
          +LKK KLR
Sbjct: 79 ILKKKKLR 86
>NP_003480
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_006724117
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_005261123
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_005261122
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_005261120
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           LLKKSK++
Sbjct: 188 LLKKSKVK 195
>XP_005259675
          Length = 404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLKKSKLR 9
          +LKK KLR
Sbjct: 79 ILKKKKLR 86
>XP_005259674
          Length = 600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LLKKSKLR 9
          +LKK KLR
Sbjct: 79 ILKKKKLR 86
>NP_001611
          Length = 5890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 5705 VKLKKSKIK 5713
>NP_001265506
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LLKKSKLR 9
           LLKKSK R
Sbjct: 123 LLKKSKHR 130
>NP_001265507
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LLKKSKLR 9
           LLKKSK R
Sbjct: 123 LLKKSKHR 130
>NP_001265505
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LLKKSKLR 9
           LLKKSK R
Sbjct: 123 LLKKSKHR 130
>NP_001265504
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LLKKSKLR 9
           LLKKSK R
Sbjct: 123 LLKKSKHR 130
>NP_775864
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LKKSKLR 9
           LK+SKLR
Sbjct: 838 LKRSKLR 844
>NP_001192202
          Length = 148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   LLKKSKLR 9
           LLKKSK R
Sbjct: 131 LLKKSKHR 138
>XP_006718751
          Length = 3489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 3304 VKLKKSKIK 3312
>XP_006718750
          Length = 4001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 3816 VKLKKSKIK 3824
>XP_005274303
          Length = 4506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 4321 VKLKKSKIK 4329
>XP_006718749
          Length = 4596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 4411 VKLKKSKIK 4419
>XP_005274302
          Length = 5438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 5253 VKLKKSKIK 5261
>XP_005274301
          Length = 5762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 5577 VKLKKSKIK 5585
>XP_005274300
          Length = 5762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 5577 VKLKKSKIK 5585
>XP_005274299
          Length = 5762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 5577 VKLKKSKIK 5585
>XP_005274298
          Length = 5890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 5705 VKLKKSKIK 5713
>XP_005274297
          Length = 5890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    VLLKKSKLR 9
            V LKKSK++
Sbjct: 5705 VKLKKSKIK 5713
>NP_114171
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   VLLKKSKLR 9
           VLLKK+ L+
Sbjct: 655 VLLKKTSLK 663
>NP_061881
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LKKSKLR 9
           LKKS+LR
Sbjct: 126 LKKSRLR 132
>NP_006556
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KKSKLR 9
           KKSKLR
Sbjct: 208 KKSKLR 213
>NP_055453
          Length = 1416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           L+K+SK+R
Sbjct: 524 LIKESKIR 531
>NP_057698
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   VLLKKSKLR 9
           ++LKKS+++
Sbjct: 182 IMLKKSRVK 190
>NP_055178
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VLLKKSK 7
            VLLKK+K
Sbjct: 1123 VLLKKAK 1129
>NP_001264984
          Length = 4432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VLLKKSK 7
           VLLKK+K
Sbjct: 976 VLLKKAK 982
>NP_001275918
          Length = 2286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1519 VLLKNKKLK 1527
>NP_001159451
          Length = 1994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1227 VLLKNKKLK 1235
>NP_057425
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1535 VLLKNKKLK 1543
>NP_079527
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KKSKLR 9
           KKSKLR
Sbjct: 855 KKSKLR 860
>NP_055871
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LKKSKLR 9
           LKK KLR
Sbjct: 631 LKKQKLR 637
>XP_006725014
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           L+K+SK+R
Sbjct: 497 LIKESKIR 504
>XP_006725013
          Length = 1389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           L+K+SK+R
Sbjct: 497 LIKESKIR 504
>XP_006725012
          Length = 1388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           L+K+SK+R
Sbjct: 497 LIKESKIR 504
>XP_005255832
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KKSKLR 9
           KKSKLR
Sbjct: 208 KKSKLR 213
>XP_005266395
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    VLLKKSK 7
            VLLKK+K
Sbjct: 1132 VLLKKAK 1138
>XP_006717953
          Length = 2008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1227 VLLKNKKLK 1235
>XP_006717952
          Length = 2300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1519 VLLKNKKLK 1527
>XP_006717951
          Length = 2315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1535 VLLKNKKLK 1543
>XP_006717950
          Length = 2316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1535 VLLKNKKLK 1543
>XP_006717949
          Length = 2316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1535 VLLKNKKLK 1543
>XP_006717948
          Length = 2316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    VLLKKSKLR 9
            VLLK  KL+
Sbjct: 1535 VLLKNKKLK 1543
>XP_006716724
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   KKSKLR 9
           KKSKLR
Sbjct: 711 KKSKLR 716
>XP_006711118
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           L+K+SK+R
Sbjct: 497 LIKESKIR 504
>XP_006711117
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLKKSKLR 9
           L+K+SK+R
Sbjct: 521 LIKESKIR 528
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.139    0.322 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 432,356
Number of extensions: 702
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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