Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              20     299
NP_001073922                                                           18    1935
NP_006009                                                              17    3301
NP_000351                                                              17    4312
NP_954986                                                              17    4312
NP_954987                                                              17    4312
NP_054799                                                              17    4312
NP_001098395                                                           17    4312
NP_078803                                                              17    4312
XP_005254478                                                           17    4312
XP_006710454                                                           17    4312
XP_006710453                                                           17    4312
XP_005270593                                                           17    4312
NP_060727                                                              17    4312
NP_001896                                                              17    4312
NP_060895                                                              16    5631
NP_991111                                                              16    5631
XP_006714627                                                           16    5631
XP_006714239                                                           16    5631
XP_006714238                                                           16    5631
XP_005263713                                                           16    5631
XP_005263712                                                           16    5631
NP_036240                                                              16    5631
NP_694983                                                              16    7355
NP_009046                                                              16    7355
NP_001273567                                                           16    7355
NP_037523                                                              16    7355
XP_006719861                                                           16    7355
XP_006719860                                                           16    7355
XP_006719859                                                           16    7355
XP_006719858                                                           16    7355
XP_006714661                                                           16    7355
XP_006714660                                                           16    7355
XP_005248232                                                           16    7355
XP_005248231                                                           16    7355
NP_060793                                                              16    7355
NP_001124481                                                           15    9605
NP_001124480                                                           15    9605
NP_002826                                                              15    9605
NP_001073279                                                           15    9605
NP_000395                                                              15    9605
NP_001243888                                                           15    9605
NP_037521                                                              15    9605
NP_001277                                                              15    9605
NP_001271151                                                           15    9605
NP_001271224                                                           15    9605
NP_001095118                                                           15    9605
NP_114100                                                              15    9605
NP_001073864                                                           15    9605
NP_001271153                                                           15    9605
NP_001271155                                                           15    9605
NP_061888                                                              15    9605
NP_001271154                                                           15    9605
NP_612463                                                              15    9605
NP_065186                                                              15    9605
NP_001036000                                                           15    9605
NP_114152                                                              15    9605
NP_002430                                                              15    9605
NP_004911                                                              15    9605
NP_001271149                                                           15    9605
XP_005257912                                                           15    9605
XP_006722260                                                           15    9605
XP_006722259                                                           15    9605
XP_006722258                                                           15    9605
XP_006722257                                                           15    9605
XP_006722256                                                           15    9605
XP_006716417                                                           15    9605
XP_006716137                                                           15    9605
XP_005250575                                                           15    9605
XP_006716136                                                           15    9605
XP_005249999                                                           15    9605
XP_006714087                                                           15    9605
XP_005248177                                                           15    9605
XP_005248176                                                           15    9605
XP_005248175                                                           15    9605
NP_060561                                                              15    9605
>NP_000312
          Length = 928

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   VLDYFIRLS 9
           VLDYFI+LS
Sbjct: 222 VLDYFIKLS 230
>NP_001073922
          Length = 2190

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           VLDYF+R
Sbjct: 971 VLDYFLR 977
>NP_006009
          Length = 387

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VLDYFIRLS 9
          V+DY++R S
Sbjct: 83 VMDYYVRRS 91
>NP_000351
          Length = 497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LDYFIRL 8
           L+YF+RL
Sbjct: 128 LEYFVRL 134
>NP_954986
          Length = 528

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LDYFIRL 8
           L+YF+RL
Sbjct: 159 LEYFVRL 165
>NP_954987
          Length = 524

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LDYFIRL 8
           L+YF+RL
Sbjct: 155 LEYFVRL 161
>NP_054799
          Length = 1548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VLDYFIRL 8
           VLD F+RL
Sbjct: 504 VLDQFVRL 511
>NP_001098395
          Length = 334

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LDYFIRLS 9
           LD+FIR S
Sbjct: 125 LDFFIRTS 132
>NP_078803
          Length = 439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LDYFIRL 8
           LD+F+RL
Sbjct: 195 LDFFVRL 201
>XP_005254478
          Length = 1548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VLDYFIRL 8
           VLD F+RL
Sbjct: 504 VLDQFVRL 511
>XP_006710454
          Length = 591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           V+DYF+R
Sbjct: 262 VVDYFLR 268
>XP_006710453
          Length = 591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           V+DYF+R
Sbjct: 262 VVDYFLR 268
>XP_005270593
          Length = 591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           V+DYF+R
Sbjct: 262 VVDYFLR 268
>NP_060727
          Length = 361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LDYFIRLS 9
           LD+FIR S
Sbjct: 125 LDFFIRTS 132
>NP_001896
          Length = 591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           V+DYF+R
Sbjct: 262 VVDYFLR 268
>NP_060895
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   VLDYFIR 7
           VLDY IR
Sbjct: 299 VLDYIIR 305
>NP_991111
          Length = 276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VLDYFIRLS 9
          +L+YF+R S
Sbjct: 15 ILEYFLRNS 23
>XP_006714627
          Length = 272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VLDYFIRLS 9
          +L+YF+R S
Sbjct: 11 ILEYFLRNS 19
>XP_006714239
          Length = 276

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           V+DYF++
Sbjct: 233 VIDYFVK 239
>XP_006714238
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           V+DYF++
Sbjct: 252 VIDYFVK 258
>XP_005263713
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LDYFIRLS 9
          L YF+R+S
Sbjct: 48 LHYFVRIS 55
>XP_005263712
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LDYFIRLS 9
          L YF+R+S
Sbjct: 48 LHYFVRIS 55
>NP_036240
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           V+DYF++
Sbjct: 252 VIDYFVK 258
>NP_694983
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           VL+YFI+
Sbjct: 189 VLEYFIK 195
>NP_009046
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLDYFIRLS 9
           ++DY IRL+
Sbjct: 110 IIDYGIRLN 118
>NP_001273567
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           VL+YFI+
Sbjct: 126 VLEYFIK 132
>NP_037523
          Length = 866

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LDYFIRLS 9
           L+YF++L+
Sbjct: 742 LEYFVKLN 749
>XP_006719861
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           VL+YFI+
Sbjct: 110 VLEYFIK 116
>XP_006719860
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           VL+YFI+
Sbjct: 189 VLEYFIK 195
>XP_006719859
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           VL+YFI+
Sbjct: 189 VLEYFIK 195
>XP_006719858
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   VLDYFIR 7
           VL+YFI+
Sbjct: 189 VLEYFIK 195
>XP_006714661
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LDYFIRLS 9
           L+YF++L+
Sbjct: 362 LEYFVKLN 369
>XP_006714660
          Length = 774

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LDYFIRLS 9
           L+YF++L+
Sbjct: 742 LEYFVKLN 749
>XP_005248232
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VLDYFIR 7
           +LDY IR
Sbjct: 199 ILDYIIR 205
>XP_005248231
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VLDYFIR 7
           +LDY IR
Sbjct: 290 ILDYIIR 296
>NP_060793
          Length = 481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   VLDYFIR 7
           +LDY IR
Sbjct: 295 ILDYIIR 301
>NP_001124481
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  DYFIR 7
          DYFIR
Sbjct: 42 DYFIR 46
>NP_001124480
          Length = 661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  DYFIR 7
          DYFIR
Sbjct: 53 DYFIR 57
>NP_002826
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   DYFIR 7
           DYFIR
Sbjct: 172 DYFIR 176
>NP_001073279
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  LDYFIRLS 9
          ++YF+RL+
Sbjct: 74 VEYFLRLA 81
>NP_000395
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LDYFIRLS 9
           ++YF+RL+
Sbjct: 104 VEYFLRLA 111
>NP_001243888
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  LDYFIRL 8
          +D+F+RL
Sbjct: 76 VDFFVRL 82
>NP_037521
          Length = 1359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLDYFIRLS 9
           +LDYF+ L+
Sbjct: 883 LLDYFLFLN 891
>NP_001277
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LDYFIRL 8
           +D+F+RL
Sbjct: 98  VDFFVRL 104
>NP_001271151
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   DYFIR 7
           DYFIR
Sbjct: 169 DYFIR 173
>NP_001271224
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLDYFIRLS 9
           V+D F+R S
Sbjct: 696 VMDVFLRFS 704
>NP_001095118
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VLDYFIRLS 9
           +LDYF+ L+
Sbjct: 883 LLDYFLFLN 891
>NP_114100
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  YFIRLS 9
          YF+RLS
Sbjct: 55 YFLRLS 60
>NP_001073864
          Length = 1374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DYFIRL 8
           +YFIRL
Sbjct: 529 EYFIRL 534
>NP_001271153
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  DYFIR 7
          DYFIR
Sbjct: 64 DYFIR 68
>NP_001271155
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  DYFIR 7
          DYFIR
Sbjct: 91 DYFIR 95
>NP_061888
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VLDYFIRLS 9
           V+D F+R S
Sbjct: 704 VMDVFLRFS 712
>NP_001271154
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  DYFIR 7
          DYFIR
Sbjct: 64 DYFIR 68
>NP_612463
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  DYFIRLS 9
          D+F+RL+
Sbjct: 56 DFFVRLT 62
>NP_065186
          Length = 1426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLDYFIRLS 9
           ++D+FI L+
Sbjct: 584 IIDFFIALA 592
>NP_001036000
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLDYFIRL 8
           V +YF+RL
Sbjct: 211 VYNYFLRL 218
>NP_114152
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLDYFIRL 8
           V +YF+RL
Sbjct: 211 VYNYFLRL 218
>NP_002430
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LDYFIR 7
           L+YFIR
Sbjct: 994 LEYFIR 999
>NP_004911
          Length = 1271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DYFIRL 8
           +YFIRL
Sbjct: 426 EYFIRL 431
>NP_001271149
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   DYFIR 7
           DYFIR
Sbjct: 111 DYFIR 115
>XP_005257912
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DYFIRL 8
           +YFIRL
Sbjct: 529 EYFIRL 534
>XP_006722260
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DYFIRL 8
           +YFIRL
Sbjct: 307 EYFIRL 312
>XP_006722259
          Length = 1326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DYFIRL 8
           +YFIRL
Sbjct: 481 EYFIRL 486
>XP_006722258
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DYFIRL 8
           +YFIRL
Sbjct: 362 EYFIRL 367
>XP_006722257
          Length = 1324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DYFIRL 8
           +YFIRL
Sbjct: 479 EYFIRL 484
>XP_006722256
          Length = 1326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DYFIRL 8
           +YFIRL
Sbjct: 481 EYFIRL 486
>XP_006716417
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  DYFIR 7
          DYFIR
Sbjct: 64 DYFIR 68
>XP_006716137
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  DYFIR 7
          DYFIR
Sbjct: 57 DYFIR 61
>XP_005250575
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  DYFIR 7
          DYFIR
Sbjct: 57 DYFIR 61
>XP_006716136
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   DYFIR 7
           DYFIR
Sbjct: 140 DYFIR 144
>XP_005249999
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VLDYFIRL 8
           V +YF+RL
Sbjct: 391 VYNYFLRL 398
>XP_006714087
          Length = 1337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLDYFIRLS 9
           ++D+FI L+
Sbjct: 495 IIDFFIALA 503
>XP_005248177
          Length = 1399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLDYFIRLS 9
           ++D+FI L+
Sbjct: 584 IIDFFIALA 592
>XP_005248176
          Length = 1411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLDYFIRLS 9
           ++D+FI L+
Sbjct: 569 IIDFFIALA 577
>XP_005248175
          Length = 1426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   VLDYFIRLS 9
           ++D+FI L+
Sbjct: 584 IIDFFIALA 592
>NP_060561
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3   DYFIR 7
           DYFIR
Sbjct: 183 DYFIR 187
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.162    0.463 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 486,295
Number of extensions: 894
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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