Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              18    1135
NP_009297                                                              18    1135
NP_001035282                                                           18    1935
NP_060303                                                              18    1935
XP_006725461                                                           18    1935
XP_006724090                                                           18    1935
NP_057090                                                              17    3301
NP_009203                                                              16    5631
NP_055847                                                              16    5631
NP_848555                                                              16    5631
NP_001077086                                                           16    5631
NP_775961                                                              16    5631
NP_001138349                                                           16    5631
NP_055596                                                              16    5631
XP_005260719                                                           16    5631
XP_006723605                                                           16    5631
XP_006723604                                                           16    5631
XP_005266355                                                           16    5631
XP_005266354                                                           16    5631
XP_005266353                                                           16    5631
XP_005266352                                                           16    5631
XP_006716556                                                           16    5631
XP_006716555                                                           16    5631
XP_006716554                                                           16    5631
NP_001177766                                                           16    7355
NP_001128512                                                           16    7355
NP_004073                                                              16    7355
NP_075408                                                              16    7355
NP_001128513                                                           16    7355
NP_001177765                                                           16    7355
NP_001804                                                              15    9605
NP_009148                                                              15    9605
NP_665858                                                              15    9605
NP_665859                                                              15    9605
NP_001238892                                                           15    9605
NP_055931                                                              15    9605
NP_001273663                                                           15    9605
NP_001238891                                                           15    9605
NP_001157683                                                           15    9605
NP_056410                                                              15    9605
NP_001157685                                                           15    9605
NP_653259                                                              15    9605
NP_940931                                                              15    9605
XP_006725061                                                           15    9605
XP_005262426                                                           15    9605
XP_005262425                                                           15    9605
XP_006721944                                                           15    9605
XP_006721943                                                           15    9605
XP_006721942                                                           15    9605
XP_005247145                                                           15    9605
XP_005247144                                                           15    9605
XP_005247143                                                           15    9605
XP_006713548                                                           15    9605
>NP_005148
          Length = 1130

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VKEISDTVQ 9
            VKEISD VQ
Sbjct: 1121 VKEISDIVQ 1129
>NP_009297
          Length = 1149

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VKEISDTVQ 9
            VKEISD VQ
Sbjct: 1140 VKEISDIVQ 1148
>NP_001035282
          Length = 388

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KEISDTVQ 9
           KEISDT++
Sbjct: 261 KEISDTIE 268
>NP_060303
          Length = 388

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KEISDTVQ 9
           KEISDT++
Sbjct: 261 KEISDTIE 268
>XP_006725461
          Length = 388

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KEISDTVQ 9
           KEISDT++
Sbjct: 261 KEISDTIE 268
>XP_006724090
          Length = 388

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KEISDTVQ 9
           KEISDT++
Sbjct: 261 KEISDTIE 268
>NP_057090
          Length = 349

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VKEISDTV 8
           VKEI DTV
Sbjct: 341 VKEICDTV 348
>NP_009203
          Length = 268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EISDTVQ 9
           E+SDT+Q
Sbjct: 132 ELSDTIQ 138
>NP_055847
          Length = 1447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VKEISDTV 8
          VKEISD +
Sbjct: 19 VKEISDKI 26
>NP_848555
          Length = 197

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VKEISDTVQ 9
          VKEI DT +
Sbjct: 86 VKEIGDTTK 94
>NP_001077086
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKEISDTVQ 9
           +KE+ DT+Q
Sbjct: 988 LKELEDTLQ 996
>NP_775961
          Length = 629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKEISDTVQ 9
           VKE+SD ++
Sbjct: 225 VKELSDEIE 233
>NP_001138349
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKEISDTVQ 9
           VKE+SD ++
Sbjct: 202 VKELSDEIE 210
>NP_055596
          Length = 1594

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKEISDTVQ 9
           +KE+ DT+Q
Sbjct: 988 LKELEDTLQ 996
>XP_005260719
          Length = 145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VKEISDTVQ 9
          VKEI DT +
Sbjct: 86 VKEIGDTTK 94
>XP_006723605
          Length = 176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VKEISDTVQ 9
          VKEI DT +
Sbjct: 64 VKEIGDTTK 72
>XP_006723604
          Length = 198

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VKEISDTVQ 9
          VKEI DT +
Sbjct: 86 VKEIGDTTK 94
>XP_005266355
          Length = 1448

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VKEISDTV 8
          VKEISD +
Sbjct: 19 VKEISDKI 26
>XP_005266354
          Length = 1411

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VKEISDTV 8
          VKEISD +
Sbjct: 19 VKEISDKI 26
>XP_005266353
          Length = 1445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VKEISDTV 8
          VKEISD +
Sbjct: 19 VKEISDKI 26
>XP_005266352
          Length = 1446

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VKEISDTV 8
          VKEISD +
Sbjct: 19 VKEISDKI 26
>XP_006716556
          Length = 1048

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKEISDTVQ 9
           +KE+ DT+Q
Sbjct: 445 LKELEDTLQ 453
>XP_006716555
          Length = 1539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKEISDTVQ 9
           +KE+ DT+Q
Sbjct: 936 LKELEDTLQ 944
>XP_006716554
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VKEISDTVQ 9
           +KE+ DT+Q
Sbjct: 988 LKELEDTLQ 996
>NP_001177766
          Length = 1271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VKEISDTVQ 9
            +K +SDTV+
Sbjct: 1185 LKSLSDTVE 1193
>NP_001128512
          Length = 1253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VKEISDTVQ 9
            +K +SDTV+
Sbjct: 1167 LKSLSDTVE 1175
>NP_004073
          Length = 1278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VKEISDTVQ 9
            +K +SDTV+
Sbjct: 1192 LKSLSDTVE 1200
>NP_075408
          Length = 1144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VKEISDTVQ 9
            +K +SDTV+
Sbjct: 1058 LKSLSDTVE 1066
>NP_001128513
          Length = 1139

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VKEISDTVQ 9
            +K +SDTV+
Sbjct: 1053 LKSLSDTVE 1061
>NP_001177765
          Length = 1236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    VKEISDTVQ 9
            +K +SDTV+
Sbjct: 1150 LKSLSDTVE 1158
>NP_001804
          Length = 2701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    VKEISDT 7
            VKE+S+T
Sbjct: 1295 VKEVSET 1301
>NP_009148
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKEISDTV 8
           +KE+ DTV
Sbjct: 138 IKELLDTV 145
>NP_665858
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKEISDTV 8
           +KE+ DTV
Sbjct: 138 IKELLDTV 145
>NP_665859
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKEISDTV 8
           +KE+ DTV
Sbjct: 138 IKELLDTV 145
>NP_001238892
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KEISDTV 8
           KE+SDT+
Sbjct: 469 KELSDTM 475
>NP_055931
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EISDTVQ 9
           ++SDTVQ
Sbjct: 95  DLSDTVQ 101
>NP_001273663
          Length = 2580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    VKEISDT 7
            VKE+S+T
Sbjct: 1270 VKEVSET 1276
>NP_001238891
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KEISDTV 8
           KE+SDT+
Sbjct: 469 KELSDTM 475
>NP_001157683
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EISDTVQ 9
           ++SDTVQ
Sbjct: 95  DLSDTVQ 101
>NP_056410
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KEISDTV 8
           KE+SDT+
Sbjct: 469 KELSDTM 475
>NP_001157685
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   EISDTVQ 9
           ++SDTVQ
Sbjct: 95  DLSDTVQ 101
>NP_653259
          Length = 2073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VKEISDTV 8
            VKE+SD +
Sbjct: 2024 VKELSDII 2031
>NP_940931
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VKEISDTVQ 9
          VKE+ +T+Q
Sbjct: 30 VKELHETLQ 38
>XP_006725061
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KEISDTV 8
           KE+SDT+
Sbjct: 469 KELSDTM 475
>XP_005262426
          Length = 2055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VKEISDTV 8
            VKE+SD +
Sbjct: 2006 VKELSDII 2013
>XP_005262425
          Length = 2086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VKEISDTV 8
            VKE+SD +
Sbjct: 2037 VKELSDII 2044
>XP_006721944
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VKEISDTVQ 9
          VKE+ +T+Q
Sbjct: 30 VKELHETLQ 38
>XP_006721943
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VKEISDTVQ 9
          VKE+ +T+Q
Sbjct: 30 VKELHETLQ 38
>XP_006721942
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VKEISDTVQ 9
          VKE+ +T+Q
Sbjct: 30 VKELHETLQ 38
>XP_005247145
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKEISDTV 8
           +KE+ DTV
Sbjct: 138 IKELLDTV 145
>XP_005247144
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKEISDTV 8
           +KE+ DTV
Sbjct: 138 IKELLDTV 145
>XP_005247143
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKEISDTV 8
           +KE+ DTV
Sbjct: 138 IKELLDTV 145
>XP_006713548
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VKEISDTV 8
           +KE+ DTV
Sbjct: 138 IKELLDTV 145
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.119    0.275 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 474,718
Number of extensions: 840
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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