Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              18    1135
NP_001245324                                                           17    3301
NP_998772                                                              17    3301
NP_001245325                                                           17    3301
NP_001161375                                                           17    3301
NP_001276336                                                           17    3301
NP_001276335                                                           17    3301
NP_073573                                                              17    3301
XP_006714215                                                           17    3301
XP_006714214                                                           17    3301
XP_005262915                                                           17    3301
XP_006713793                                                           17    3301
NP_055806                                                              17    3301
NP_001191387                                                           17    4312
NP_001191388                                                           17    4312
NP_683760                                                              17    4312
NP_000856                                                              17    4312
NP_061117                                                              17    4312
XP_005266503                                                           17    4312
XP_005266502                                                           17    4312
XP_005264808                                                           17    4312
XP_005264807                                                           17    4312
XP_005264806                                                           17    4312
XP_005264805                                                           17    4312
XP_005264804                                                           17    4312
NP_000857                                                              17    4312
NP_001135791                                                           16    5631
NP_061325                                                              16    5631
NP_940998                                                              16    5631
NP_079479                                                              16    5631
NP_001155313                                                           16    5631
NP_997253                                                              16    5631
XP_005260516                                                           16    5631
XP_006723893                                                           16    5631
XP_005260515                                                           16    5631
XP_006723892                                                           16    5631
XP_006723891                                                           16    5631
XP_006723890                                                           16    5631
XP_005259257                                                           16    5631
XP_005259256                                                           16    5631
NP_003361                                                              16    5631
NP_004027                                                              16    7355
NP_001171985                                                           16    7355
NP_001185497                                                           16    7355
NP_640340                                                              16    7355
NP_001185521                                                           16    7355
XP_006711990                                                           16    7355
XP_005264162                                                           16    7355
XP_005264161                                                           16    7355
XP_005264159                                                           16    7355
XP_006711989                                                           16    7355
XP_006711988                                                           16    7355
NP_005593                                                              16    7355
NP_061751                                                              16    7355
NP_115782                                                              16    7355
NP_056169                                                              15    9605
NP_061977                                                              15    9605
XP_005256115                                                           15    9605
XP_005256114                                                           15    9605
XP_005256113                                                           15    9605
>NP_002430
          Length = 1137

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VICSLAATI 9
           VICSLAA I
Sbjct: 499 VICSLAAII 507
>NP_001245324
          Length = 242

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VICSLAAT 8
           ++CSLA+T
Sbjct: 166 ILCSLAST 173
>NP_998772
          Length = 242

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VICSLAAT 8
           ++CSLA+T
Sbjct: 166 ILCSLAST 173
>NP_001245325
          Length = 242

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VICSLAAT 8
           ++CSLA+T
Sbjct: 166 ILCSLAST 173
>NP_001161375
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VICSLAATI 9
           V+C++AAT+
Sbjct: 344 VLCAVAATL 352
>NP_001276336
          Length = 392

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VICSLAATI 9
           V+C++AAT+
Sbjct: 261 VLCAVAATL 269
>NP_001276335
          Length = 368

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VICSLAATI 9
           V+C++AAT+
Sbjct: 237 VLCAVAATL 245
>NP_073573
          Length = 514

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VICSLAATI 9
           V+C++AAT+
Sbjct: 383 VLCAVAATL 391
>XP_006714215
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ICSLAATI 9
            +C+LAAT+
Sbjct: 1913 LCALAATV 1920
>XP_006714214
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ICSLAATI 9
            +C+LAAT+
Sbjct: 1913 LCALAATV 1920
>XP_005262915
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ICSLAATI 9
            +C+LAAT+
Sbjct: 1913 LCALAATV 1920
>XP_006713793
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   VICSLAATI 9
           V+C++AAT+
Sbjct: 344 VLCAVAATL 352
>NP_055806
          Length = 3526

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ICSLAATI 9
            +C+LAAT+
Sbjct: 1895 LCALAATV 1902
>NP_001191387
          Length = 417

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VICSLAATI 9
           VICS  AT+
Sbjct: 173 VICSALATV 181
>NP_001191388
          Length = 285

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VICSLAATI 9
          VICS  AT+
Sbjct: 41 VICSALATV 49
>NP_683760
          Length = 417

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VICSLAATI 9
           VICS  AT+
Sbjct: 173 VICSALATV 181
>NP_000856
          Length = 365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VICSLAAT 8
          +ICSLA T
Sbjct: 60 LICSLAVT 67
>NP_061117
          Length = 423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VICSLAATI 9
           VICS  AT+
Sbjct: 173 VICSALATV 181
>XP_005266503
          Length = 328

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VICSLAATI 9
           VICS  AT+
Sbjct: 173 VICSALATV 181
>XP_005266502
          Length = 423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VICSLAATI 9
           VICS  AT+
Sbjct: 173 VICSALATV 181
>XP_005264808
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VICSLAAT 8
          +ICSLA T
Sbjct: 61 LICSLAVT 68
>XP_005264807
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VICSLAAT 8
          +ICSLA T
Sbjct: 61 LICSLAVT 68
>XP_005264806
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VICSLAAT 8
          +ICSLA T
Sbjct: 61 LICSLAVT 68
>XP_005264805
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VICSLAAT 8
          +ICSLA T
Sbjct: 61 LICSLAVT 68
>XP_005264804
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VICSLAAT 8
          +ICSLA T
Sbjct: 61 LICSLAVT 68
>NP_000857
          Length = 366

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VICSLAAT 8
          +ICSLA T
Sbjct: 61 LICSLAVT 68
>NP_001135791
          Length = 622

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   ICSLAATI 9
           +CS+ AT+
Sbjct: 206 VCSITATV 213
>NP_061325
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>NP_940998
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>NP_079479
          Length = 721

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   ICSLAATI 9
           +CS+ AT+
Sbjct: 206 VCSITATV 213
>NP_001155313
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>NP_997253
          Length = 609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  VICSLAAT 8
          ++C+LAAT
Sbjct: 45 LLCTLAAT 52
>XP_005260516
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>XP_006723893
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>XP_005260515
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>XP_006723892
          Length = 871

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>XP_006723891
          Length = 871

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>XP_006723890
          Length = 871

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C L+AT+
Sbjct: 7  VLCLLSATV 15
>XP_005259257
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VICSLAATI 9
          VICS  AT+
Sbjct: 5  VICSSRATV 13
>XP_005259256
          Length = 379

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VICSLAATI 9
          VICS  AT+
Sbjct: 5  VICSSRATV 13
>NP_003361
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  VICSLAATI 9
          VICS  AT+
Sbjct: 5  VICSSRATV 13
>NP_004027
          Length = 1144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ICSLAA 7
           ICSLAA
Sbjct: 676 ICSLAA 681
>NP_001171985
          Length = 123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ICSLAATI 9
          +C+L ATI
Sbjct: 48 LCALVATI 55
>NP_001185497
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C+LAA +
Sbjct: 37 VLCALAALL 45
>NP_640340
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C+LAA +
Sbjct: 37 VLCALAALL 45
>NP_001185521
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  VICSLAATI 9
          V+C+LAA +
Sbjct: 37 VLCALAALL 45
>XP_006711990
          Length = 1131

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ICSLAA 7
           ICSLAA
Sbjct: 698 ICSLAA 703
>XP_005264162
          Length = 1144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ICSLAA 7
           ICSLAA
Sbjct: 676 ICSLAA 681
>XP_005264161
          Length = 1145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ICSLAA 7
           ICSLAA
Sbjct: 676 ICSLAA 681
>XP_005264159
          Length = 1166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ICSLAA 7
           ICSLAA
Sbjct: 698 ICSLAA 703
>XP_006711989
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ICSLAA 7
           ICSLAA
Sbjct: 698 ICSLAA 703
>XP_006711988
          Length = 1167

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   ICSLAA 7
           ICSLAA
Sbjct: 698 ICSLAA 703
>NP_005593
          Length = 207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ICSLAATI 9
           +C+L ATI
Sbjct: 132 LCALVATI 139
>NP_061751
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VICSLAAT 8
           ++CSLAA+
Sbjct: 473 LLCSLAAS 480
>NP_115782
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VICSLAAT 8
           ++CSLAA+
Sbjct: 473 LLCSLAAS 480
>NP_056169
          Length = 1749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ICSLAAT 8
           ICSLA T
Sbjct: 765 ICSLAYT 771
>NP_061977
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  CSLAAT 8
          CS+AAT
Sbjct: 56 CSIAAT 61
>XP_005256115
          Length = 162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  ICSLAA 7
          +CSLAA
Sbjct: 68 VCSLAA 73
>XP_005256114
          Length = 181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  ICSLAA 7
          +CSLAA
Sbjct: 68 VCSLAA 73
>XP_005256113
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  ICSLAA 7
          +CSLAA
Sbjct: 68 VCSLAA 73
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.134    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 583,221
Number of extensions: 627
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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