Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           19     869
NP_004561                                                              19     869
NP_001275703                                                           19     869
XP_005253450                                                           19     869
XP_006719151                                                           19     869
NP_060009                                                              17    3301
XP_006721125                                                           17    3301
NP_001265588                                                           17    4312
NP_940905                                                              17    4312
NP_001274748                                                           17    4312
NP_001274749                                                           17    4312
NP_001265587                                                           17    4312
NP_000331                                                              17    4312
NP_001265225                                                           17    4312
NP_001265224                                                           17    4312
XP_006712460                                                           17    4312
XP_006711360                                                           17    4312
XP_006711359                                                           17    4312
XP_006711358                                                           17    4312
XP_006711357                                                           17    4312
NP_055873                                                              16    5631
NP_443078                                                              16    5631
NP_001020368                                                           16    5631
XP_006719854                                                           16    5631
XP_006719853                                                           16    5631
NP_003991                                                              16    5631
NP_001020370                                                           16    5631
NP_000024                                                              16    7355
NP_001036694                                                           16    7355
NP_001243376                                                           16    7355
NP_005736                                                              16    7355
NP_001132913                                                           16    7355
NP_073739                                                              16    7355
NP_079341                                                              16    7355
NP_001132929                                                           16    7355
NP_055617                                                              16    7355
NP_001116151                                                           16    7355
NP_001273106                                                           16    7355
NP_001273105                                                           16    7355
NP_001273104                                                           16    7355
NP_001273103                                                           16    7355
NP_001273102                                                           16    7355
XP_005253596                                                           16    7355
XP_005253595                                                           16    7355
XP_006719233                                                           16    7355
XP_006719232                                                           16    7355
XP_006719231                                                           16    7355
XP_006719230                                                           16    7355
XP_006719229                                                           16    7355
XP_006719228                                                           16    7355
XP_006719227                                                           16    7355
XP_005274289                                                           16    7355
XP_005266009                                                           16    7355
XP_006714961                                                           16    7355
XP_006714960                                                           16    7355
XP_005266007                                                           16    7355
XP_005272109                                                           16    7355
NP_005155                                                              16    7355
NP_009057                                                              15    9605
NP_000381                                                              15    9605
NP_001265230                                                           15    9605
NP_612357                                                              15    9605
NP_001073917                                                           15    9605
XP_006724678                                                           15    9605
XP_006713655                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VGYDEVTEL 9
            V YDEVTEL
Sbjct: 1437 VVYDEVTEL 1445
>NP_004561
          Length = 1445

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VGYDEVTEL 9
            V YDEVTEL
Sbjct: 1396 VVYDEVTEL 1404
>NP_001275703
          Length = 1264

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VGYDEVTEL 9
            V YDEVTEL
Sbjct: 1215 VVYDEVTEL 1223
>XP_005253450
          Length = 1486

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VGYDEVTEL 9
            V YDEVTEL
Sbjct: 1437 VVYDEVTEL 1445
>XP_006719151
          Length = 1486

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    VGYDEVTEL 9
            V YDEVTEL
Sbjct: 1437 VVYDEVTEL 1445
>NP_060009
          Length = 4116

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YDEVTEL 9
            YDE+T+L
Sbjct: 2376 YDEITDL 2382
>XP_006721125
          Length = 4070

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YDEVTEL 9
            YDE+T+L
Sbjct: 2330 YDEITDL 2336
>NP_001265588
          Length = 351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GYDEVTE 8
          GYD+VT+
Sbjct: 92 GYDDVTK 98
>NP_940905
          Length = 1135

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VGYDEVTE 8
            VGYDE+ +
Sbjct: 1068 VGYDEMND 1075
>NP_001274748
          Length = 1111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VGYDEVTE 8
            VGYDE+ +
Sbjct: 1044 VGYDEMND 1051
>NP_001274749
          Length = 1068

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VGYDEVTE 8
            VGYDE+ +
Sbjct: 1001 VGYDEMND 1008
>NP_001265587
          Length = 405

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GYDEVTE 8
           GYD+VT+
Sbjct: 146 GYDDVTK 152
>NP_000331
          Length = 524

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GYDEVTE 8
           GYD+VT+
Sbjct: 265 GYDDVTK 271
>NP_001265225
          Length = 730

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VGYDEVTE 8
           VG+ EVTE
Sbjct: 693 VGWQEVTE 700
>NP_001265224
          Length = 784

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VGYDEVTE 8
           VG+ EVTE
Sbjct: 747 VGWQEVTE 754
>XP_006712460
          Length = 784

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   VGYDEVTE 8
           VG+ EVTE
Sbjct: 747 VGWQEVTE 754
>XP_006711360
          Length = 699

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VGYDEVTE 8
           VGYDE+ +
Sbjct: 632 VGYDEMND 639
>XP_006711359
          Length = 752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VGYDEVTE 8
           VGYDE+ +
Sbjct: 685 VGYDEMND 692
>XP_006711358
          Length = 1118

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VGYDEVTE 8
            VGYDE+ +
Sbjct: 1051 VGYDEMND 1058
>XP_006711357
          Length = 1142

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    VGYDEVTE 8
            VGYDE+ +
Sbjct: 1075 VGYDEMND 1082
>NP_055873
          Length = 1905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    GYDEVTEL 9
            GY EVT+L
Sbjct: 1451 GYIEVTDL 1458
>NP_443078
          Length = 766

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VGYDEVTEL 9
           VGY  VT+L
Sbjct: 108 VGYKTVTDL 116
>NP_001020368
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VGYDEVTEL 9
           VGYD+V  +
Sbjct: 324 VGYDDVKSM 332
>XP_006719854
          Length = 1550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    GYDEVTEL 9
            GY EVT+L
Sbjct: 1096 GYIEVTDL 1103
>XP_006719853
          Length = 1809

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    GYDEVTEL 9
            GY EVT+L
Sbjct: 1355 GYIEVTDL 1362
>NP_003991
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VGYDEVTEL 9
           VGYD+V  +
Sbjct: 334 VGYDDVKSM 342
>NP_001020370
          Length = 311

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VGYDEVTEL 9
           VGYD+V  +
Sbjct: 255 VGYDDVKSM 263
>NP_000024
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YDEVTEL 9
           Y EVTEL
Sbjct: 406 YKEVTEL 412
>NP_001036694
          Length = 240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  GYDEVTEL 9
          GYDEV  L
Sbjct: 56 GYDEVQGL 63
>NP_001243376
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  YDEVTE 8
          YD+VTE
Sbjct: 73 YDDVTE 78
>NP_005736
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  YDEVTE 8
          YD+VTE
Sbjct: 73 YDDVTE 78
>NP_001132913
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  YDEVTE 8
          YD+VTE
Sbjct: 73 YDDVTE 78
>NP_073739
          Length = 1430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GYDEVTEL 9
           GYDE+  L
Sbjct: 631 GYDEIVGL 638
>NP_079341
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   VGYDEVTE 8
           V YDE T+
Sbjct: 123 VAYDEATD 130
>NP_001132929
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YDEVTE 8
           YD+VTE
Sbjct: 140 YDDVTE 145
>NP_055617
          Length = 1000

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 663 DEVTEL 668
>NP_001116151
          Length = 2765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    GYDEVT 7
            GYDE T
Sbjct: 2032 GYDETT 2037
>NP_001273106
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 654 DEVTEL 659
>NP_001273105
          Length = 1051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 663 DEVTEL 668
>NP_001273104
          Length = 1054

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 676 DEVTEL 681
>NP_001273103
          Length = 1051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 663 DEVTEL 668
>NP_001273102
          Length = 1053

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 665 DEVTEL 670
>XP_005253596
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 285 DEVTEL 290
>XP_005253595
          Length = 991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 654 DEVTEL 659
>XP_006719233
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 663 DEVTEL 668
>XP_006719232
          Length = 1033

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 696 DEVTEL 701
>XP_006719231
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 674 DEVTEL 679
>XP_006719230
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 696 DEVTEL 701
>XP_006719229
          Length = 1073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 685 DEVTEL 690
>XP_006719228
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 687 DEVTEL 692
>XP_006719227
          Length = 1084

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DEVTEL 9
           DEVTEL
Sbjct: 696 DEVTEL 701
>XP_005274289
          Length = 363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GYDEVTEL 9
           GYDEV  L
Sbjct: 179 GYDEVQGL 186
>XP_005266009
          Length = 2378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    GYDEVT 7
            GYDE T
Sbjct: 1645 GYDETT 1650
>XP_006714961
          Length = 2548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    GYDEVT 7
            GYDE T
Sbjct: 1815 GYDETT 1820
>XP_006714960
          Length = 2758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    GYDEVT 7
            GYDE T
Sbjct: 2025 GYDETT 2030
>XP_005266007
          Length = 2765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    GYDEVT 7
            GYDE T
Sbjct: 2032 GYDETT 2037
>XP_005272109
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GYDEVTEL 9
           GYDE+  L
Sbjct: 631 GYDEIVGL 638
>NP_005155
          Length = 740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YDEVTEL 9
           Y EVTEL
Sbjct: 410 YKEVTEL 416
>NP_009057
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   VGYDEV 6
           VGYD++
Sbjct: 201 VGYDDI 206
>NP_000381
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GYDEVT 7
           GY+E+T
Sbjct: 314 GYEEIT 319
>NP_001265230
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GYDEVTEL 9
           G+D +TE+
Sbjct: 150 GWDAITEM 157
>NP_612357
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   VGYDEVTE 8
           +GY+EV++
Sbjct: 108 MGYEEVSQ 115
>NP_001073917
          Length = 1130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GYDEVTEL 9
           G+D +TE+
Sbjct: 150 GWDAITEM 157
>XP_006724678
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GYDEVT 7
           GY+E+T
Sbjct: 293 GYEEIT 298
>XP_006713655
          Length = 1146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GYDEVTEL 9
           G+D +TE+
Sbjct: 150 GWDAITEM 157
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.138    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 593,924
Number of extensions: 1027
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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