Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_006234                                                              17    2528
NP_001186685                                                           17    2528
NP_001269109                                                           17    2528
NP_006237                                                              17    2528
NP_001269111                                                           17    2528
NP_001269110                                                           17    2528
NP_001269108                                                           17    2528
NP_000937                                                              17    4312
NP_001071107                                                           17    4312
NP_060148                                                              17    4312
NP_001136076                                                           16    5631
NP_000301                                                              16    5631
NP_001155197                                                           16    5631
NP_848702                                                              16    5631
NP_001155198                                                           16    5631
NP_848701                                                              16    5631
NP_002710                                                              16    5631
XP_005267884                                                           16    5631
XP_005267883                                                           16    5631
XP_005267881                                                           16    5631
XP_005267880                                                           16    5631
XP_005267879                                                           16    5631
XP_005267877                                                           16    5631
XP_005267876                                                           16    5631
XP_005271065                                                           16    5631
XP_005271064                                                           16    5631
NP_004945                                                              15    9605
NP_059672                                                              15    9605
NP_001121167                                                           15    9605
NP_001161066                                                           15    9605
NP_000299                                                              15    9605
NP_775899                                                              15    9605
NP_003123                                                              15    9605
XP_006718509                                                           15    9605
XP_006718505                                                           15    9605
XP_006718504                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  VFVRKSLNN 9
          VFVRKSLN+
Sbjct: 67 VFVRKSLNS 75
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  VFVRKSLNN 9
          VFVRKSLN+
Sbjct: 67 VFVRKSLNS 75
>NP_006234
          Length = 486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           F+RK +NN
Sbjct: 224 FIRKQINN 231
>NP_001186685
          Length = 429

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           F+RK +NN
Sbjct: 167 FIRKQINN 174
>NP_001269109
          Length = 462

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           F+RK +NN
Sbjct: 216 FIRKQINN 223
>NP_006237
          Length = 467

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           F+RK +NN
Sbjct: 216 FIRKQINN 223
>NP_001269111
          Length = 391

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           F+RK +NN
Sbjct: 140 FIRKQINN 147
>NP_001269110
          Length = 391

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           F+RK +NN
Sbjct: 140 FIRKQINN 147
>NP_001269108
          Length = 467

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           F+RK +NN
Sbjct: 216 FIRKQINN 223
>NP_000937
          Length = 420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           F+RKS+N
Sbjct: 211 FIRKSIN 217
>NP_001071107
          Length = 544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VFVRKSLN 8
           VF+R++LN
Sbjct: 446 VFIRRALN 453
>NP_060148
          Length = 260

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   VFVRKSLN 8
           VF+R++LN
Sbjct: 162 VFIRRALN 169
>NP_001136076
          Length = 203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  FVRKSLN 8
          F+RK+LN
Sbjct: 59 FIRKTLN 65
>NP_000301
          Length = 306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           F+RK+LN
Sbjct: 162 FIRKTLN 168
>NP_001155197
          Length = 555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 230 YIRKQINN 237
>NP_848702
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 199 YIRKQINN 206
>NP_001155198
          Length = 540

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 254 YIRKQINN 261
>NP_848701
          Length = 485

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 199 YIRKQINN 206
>NP_002710
          Length = 524

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 199 YIRKQINN 206
>XP_005267884
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 124 YIRKQINN 131
>XP_005267883
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 175 YIRKQINN 182
>XP_005267881
          Length = 539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 259 YIRKQINN 266
>XP_005267880
          Length = 545

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 259 YIRKQINN 266
>XP_005267879
          Length = 556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 259 YIRKQINN 266
>XP_005267877
          Length = 579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 254 YIRKQINN 261
>XP_005267876
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           ++RK +NN
Sbjct: 259 YIRKQINN 266
>XP_005271065
          Length = 282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           F+RK+LN
Sbjct: 162 FIRKTLN 168
>XP_005271064
          Length = 339

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           F+RK+LN
Sbjct: 162 FIRKTLN 168
>NP_004945
          Length = 724

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           FVR++LN
Sbjct: 587 FVRRNLN 593
>NP_059672
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           FVR++LN
Sbjct: 608 FVRRNLN 614
>NP_001121167
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           +VRK+LN
Sbjct: 345 YVRKALN 351
>NP_001161066
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           +VRK+LN
Sbjct: 346 YVRKALN 352
>NP_000299
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           +VRK+LN
Sbjct: 363 YVRKALN 369
>NP_775899
          Length = 4462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           F+RKSL+
Sbjct: 877 FIRKSLS 883
>NP_003123
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FVRKSLNN 9
           F RK+LN+
Sbjct: 293 FARKALND 300
>XP_006718509
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           FVR++LN
Sbjct: 588 FVRRNLN 594
>XP_006718505
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           FVR++LN
Sbjct: 641 FVRRNLN 647
>XP_006718504
          Length = 779

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FVRKSLN 8
           FVR++LN
Sbjct: 642 FVRRNLN 648
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.136    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 395,704
Number of extensions: 534
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package