Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001276866                                                           18    1482
NP_004439                                                              18    1482
NP_001276865                                                           18    1482
NP_001005862                                                           18    1482
XP_005257197                                                           18    1482
XP_006721828                                                           18    1482
NP_001273538                                                           17    3301
NP_115507                                                              17    3301
XP_006715637                                                           17    3301
XP_005267214                                                           17    3301
XP_005267213                                                           17    3301
XP_006715636                                                           17    3301
XP_005267212                                                           17    3301
XP_005267211                                                           17    3301
NP_001035519                                                           16    5631
NP_056157                                                              16    5631
XP_005266415                                                           16    5631
XP_005266414                                                           16    5631
NP_001171809                                                           16    7355
NP_001098713                                                           16    7355
NP_065817                                                              16    7355
NP_065681                                                              15    9605
NP_066124                                                              15    9605
NP_057460                                                              15    9605
NP_001265393                                                           15    9605
NP_036192                                                              15    9605
NP_005681                                                              15    9605
NP_036193                                                              15    9605
NP_001265392                                                           15    9605
NP_001265394                                                           15    9605
NP_001244928                                                           15    9605
NP_036442                                                              15    9605
NP_003904                                                              15    9605
NP_002908                                                              15    9605
XP_006721607                                                           15    9605
XP_005256736                                                           15    9605
XP_005253340                                                           15    9605
XP_005253339                                                           15    9605
XP_006717999                                                           15    9605
XP_006715301                                                           15    9605
XP_005270452                                                           15    9605
NP_001092763                                                           15    9605
NP_006836                                                              15    9605
>NP_001276866
          Length = 1055

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VAIKV REN
Sbjct: 750 VAIKVLREN 758
>NP_004439
          Length = 1255

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VAIKV REN
Sbjct: 750 VAIKVLREN 758
>NP_001276865
          Length = 1240

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VAIKV REN
Sbjct: 735 VAIKVLREN 743
>NP_001005862
          Length = 1225

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VAIKV REN
Sbjct: 720 VAIKVLREN 728
>XP_005257197
          Length = 1225

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VAIKV REN
Sbjct: 720 VAIKVLREN 728
>XP_006721828
          Length = 1336

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VAIKV REN
Sbjct: 831 VAIKVLREN 839
>NP_001273538
          Length = 702

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VAIKVSREN 9
           +A+KVSR+N
Sbjct: 175 LALKVSRKN 183
>NP_115507
          Length = 867

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VAIKVSREN 9
           +A+KVSR+N
Sbjct: 340 LALKVSRKN 348
>XP_006715637
          Length = 702

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VAIKVSREN 9
           +A+KVSR+N
Sbjct: 175 LALKVSRKN 183
>XP_005267214
          Length = 702

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VAIKVSREN 9
           +A+KVSR+N
Sbjct: 175 LALKVSRKN 183
>XP_005267213
          Length = 867

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VAIKVSREN 9
           +A+KVSR+N
Sbjct: 340 LALKVSRKN 348
>XP_006715636
          Length = 867

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VAIKVSREN 9
           +A+KVSR+N
Sbjct: 340 LALKVSRKN 348
>XP_005267212
          Length = 867

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VAIKVSREN 9
           +A+KVSR+N
Sbjct: 340 LALKVSRKN 348
>XP_005267211
          Length = 867

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   VAIKVSREN 9
           +A+KVSR+N
Sbjct: 340 LALKVSRKN 348
>NP_001035519
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAIKVSREN 9
           +A+K  REN
Sbjct: 726 IAVKCKREN 734
>NP_056157
          Length = 646

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  VAIKVSREN 9
          VA+ VS+EN
Sbjct: 34 VAVAVSQEN 42
>XP_005266415
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAIKVSREN 9
           +A+K  REN
Sbjct: 726 IAVKCKREN 734
>XP_005266414
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAIKVSREN 9
           +A+K  REN
Sbjct: 726 IAVKCKREN 734
>NP_001171809
          Length = 1148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VAIKVSREN 9
           VAIK  R+N
Sbjct: 699 VAIKCKRDN 707
>NP_001098713
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VAIKVSREN 9
           VAIK  R+N
Sbjct: 699 VAIKCKRDN 707
>NP_065817
          Length = 1100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   VAIKVSREN 9
           VAIK  R+N
Sbjct: 699 VAIKCKRDN 707
>NP_065681
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VA+K+ +EN
Sbjct: 755 VAVKMLKEN 763
>NP_066124
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VA+K+ +EN
Sbjct: 755 VAVKMLKEN 763
>NP_057460
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AIKVSREN 9
           AIKV RE+
Sbjct: 225 AIKVERED 232
>NP_001265393
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKVSRE 8
           A+K+SRE
Sbjct: 209 ALKISRE 215
>NP_036192
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKVSRE 8
           A+K+SRE
Sbjct: 196 ALKISRE 202
>NP_005681
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKVSRE 8
           A+K+SRE
Sbjct: 196 ALKISRE 202
>NP_036193
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKVSRE 8
           A+K+SRE
Sbjct: 196 ALKISRE 202
>NP_001265392
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKVSRE 8
           A+K+SRE
Sbjct: 196 ALKISRE 202
>NP_001265394
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKVSRE 8
           A+K+SRE
Sbjct: 209 ALKISRE 215
>NP_001244928
          Length = 1211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AIKVSREN 9
           AIKV RE+
Sbjct: 267 AIKVERED 274
>NP_036442
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    IKVSREN 9
            +KVSR+N
Sbjct: 1076 VKVSRKN 1082
>NP_003904
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAIKVSREN 9
           VA+K+ R N
Sbjct: 714 VAVKIIRNN 722
>NP_002908
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  VAIKVSREN 9
          +A+K +R+N
Sbjct: 62 IAVKTTRKN 70
>XP_006721607
          Length = 1130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AIKVSREN 9
           AIKV RE+
Sbjct: 225 AIKVERED 232
>XP_005256736
          Length = 1169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AIKVSREN 9
           AIKV RE+
Sbjct: 225 AIKVERED 232
>XP_005253340
          Length = 587

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIKVSRE 8
          A+K+SRE
Sbjct: 47 ALKISRE 53
>XP_005253339
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIKVSRE 8
           A+K+SRE
Sbjct: 209 ALKISRE 215
>XP_006717999
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   VAIKVSREN 9
           VA+K+ +EN
Sbjct: 848 VAVKMLKEN 856
>XP_006715301
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   VAIKVSREN 9
           VA+K+ R N
Sbjct: 714 VAVKIIRNN 722
>XP_005270452
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VAIKVSREN 9
          +AIK+ R N
Sbjct: 15 LAIKIQRSN 23
>NP_001092763
          Length = 1234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    IKVSREN 9
            +KVSR+N
Sbjct: 1078 VKVSRKN 1084
>NP_006836
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VAIKVSREN 9
          +AIK+ R N
Sbjct: 15 LAIKIQRSN 23
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.122    0.283 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 332,591
Number of extensions: 598
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package