Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           20     509
NP_060785                                                              20     509
NP_361014                                                              20     509
XP_006717797                                                           18    1935
NP_056005                                                              18    1935
NP_055954                                                              17    2528
XP_006710543                                                           17    2528
XP_006710542                                                           17    2528
XP_006710541                                                           17    2528
XP_005253164                                                           17    3301
NP_036432                                                              17    4312
NP_387449                                                              17    4312
NP_387448                                                              17    4312
NP_001243785                                                           17    4312
NP_378663                                                              17    4312
NP_003930                                                              17    4312
NP_848549                                                              17    4312
NP_060004                                                              17    4312
NP_001093582                                                           17    4312
NP_114124                                                              17    4312
XP_005270321                                                           17    4312
XP_006718117                                                           17    4312
XP_005265916                                                           17    4312
XP_005265915                                                           17    4312
XP_005265914                                                           17    4312
XP_005265913                                                           17    4312
XP_005265912                                                           17    4312
XP_005270526                                                           17    4312
XP_005270527                                                           17    4312
NP_073153                                                              16    5631
XP_006726446                                                           16    5631
XP_006712754                                                           16    5631
XP_006712753                                                           16    5631
XP_006712221                                                           16    5631
NP_038347                                                              16    7355
NP_001275762                                                           16    7355
NP_036257                                                              16    7355
NP_071415                                                              16    7355
NP_000862                                                              16    7355
NP_002680                                                              16    7355
XP_006724993                                                           16    7355
XP_006724460                                                           16    7355
XP_005254198                                                           16    7355
XP_005248624                                                           16    7355
NP_038265                                                              16    7355
NP_001096640                                                           15    9605
NP_002461                                                              15    9605
NP_054865                                                              15    9605
NP_006775                                                              15    9605
NP_005954                                                              15    9605
NP_115852                                                              15    9605
NP_115853                                                              15    9605
NP_003793                                                              15    9605
NP_060003                                                              15    9605
XP_006722202                                                           15    9605
XP_005257794                                                           15    9605
XP_005256707                                                           15    9605
XP_006721591                                                           15    9605
XP_005250619                                                           15    9605
XP_005263968                                                           15    9605
XP_005263967                                                           15    9605
XP_005263966                                                           15    9605
NP_115752                                                              15    9605
>NP_001013433
          Length = 589

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAAVLCVQY 9
           VAAV CVQY
Sbjct: 383 VAAVRCVQY 391
>NP_060785
          Length = 627

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAAVLCVQY 9
           VAAV CVQY
Sbjct: 421 VAAVRCVQY 429
>NP_361014
          Length = 707

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   VAAVLCVQY 9
           VAAV CVQY
Sbjct: 501 VAAVRCVQY 509
>XP_006717797
          Length = 238

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLCVQY
Sbjct: 147 SVLCVQY 153
>NP_056005
          Length = 260

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLCVQY
Sbjct: 147 SVLCVQY 153
>NP_055954
          Length = 355

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AAVLCVQY 9
           A VLC QY
Sbjct: 272 ATVLCTQY 279
>XP_006710543
          Length = 256

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AAVLCVQY 9
           A VLC QY
Sbjct: 173 ATVLCTQY 180
>XP_006710542
          Length = 359

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AAVLCVQY 9
           A VLC QY
Sbjct: 276 ATVLCTQY 283
>XP_006710541
          Length = 382

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AAVLCVQY 9
           A VLC QY
Sbjct: 299 ATVLCTQY 306
>XP_005253164
          Length = 387

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   VAAVLCVQ 8
           VAAVLC Q
Sbjct: 376 VAAVLCPQ 383
>NP_036432
          Length = 542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 282 SVLCLQY 288
>NP_387449
          Length = 508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 248 SVLCLQY 254
>NP_387448
          Length = 529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 269 SVLCLQY 275
>NP_001243785
          Length = 579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 319 SVLCLQY 325
>NP_378663
          Length = 605

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 345 SVLCLQY 351
>NP_003930
          Length = 569

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 309 SVLCLQY 315
>NP_848549
          Length = 266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VAAVLCV 7
          +AAVLC+
Sbjct: 62 IAAVLCI 68
>NP_060004
          Length = 1941

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           A+ C+QY
Sbjct: 816 AIFCIQY 822
>NP_001093582
          Length = 1941

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           A+ C+QY
Sbjct: 816 AIFCIQY 822
>NP_114124
          Length = 252

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  AAVLCVQY 9
          AAV CV Y
Sbjct: 3  AAVACVDY 10
>XP_005270321
          Length = 326

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  AVLCVQY 9
          +VLC+QY
Sbjct: 66 SVLCLQY 72
>XP_006718117
          Length = 732

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 472 SVLCLQY 478
>XP_005265916
          Length = 494

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 234 SVLCLQY 240
>XP_005265915
          Length = 510

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 250 SVLCLQY 256
>XP_005265914
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 255 SVLCLQY 261
>XP_005265913
          Length = 531

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 271 SVLCLQY 277
>XP_005265912
          Length = 563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVLCVQY 9
           +VLC+QY
Sbjct: 303 SVLCLQY 309
>XP_005270526
          Length = 266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VAAVLCV 7
          +AAVLC+
Sbjct: 62 IAAVLCI 68
>XP_005270527
          Length = 266

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VAAVLCV 7
          +AAVLC+
Sbjct: 62 IAAVLCI 68
>NP_073153
          Length = 1944

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VAAVLCVQY 9
            +AA+LC  Y
Sbjct: 1581 IAALLCALY 1589
>XP_006726446
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VAAVLCVQY 9
          +AA+LC  Y
Sbjct: 86 IAALLCALY 94
>XP_006712754
          Length = 1784

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VAAVLCVQY 9
            +AA+LC  Y
Sbjct: 1421 IAALLCALY 1429
>XP_006712753
          Length = 1846

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    VAAVLCVQY 9
            +AA+LC  Y
Sbjct: 1483 IAALLCALY 1491
>XP_006712221
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  VAAVLCVQY 9
          +AA+LC  Y
Sbjct: 86 IAALLCALY 94
>NP_038347
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VAAVLCV 7
          +AA+LCV
Sbjct: 69 IAALLCV 75
>NP_001275762
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VAAVLCV 7
          +AA+LCV
Sbjct: 69 IAALLCV 75
>NP_036257
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           A+LC QY
Sbjct: 165 AILCWQY 171
>NP_071415
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VAAVLCVQ 8
           VAAV C Q
Sbjct: 426 VAAVACAQ 433
>NP_000862
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  VAAVLCV 7
          VAA LCV
Sbjct: 29 VAAALCV 35
>NP_002680
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5  LCVQY 9
          LCVQY
Sbjct: 30 LCVQY 34
>XP_006724993
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VAAVLCV 7
          +AA+LCV
Sbjct: 69 IAALLCV 75
>XP_006724460
          Length = 574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VAAVLCV 7
          +AA+LCV
Sbjct: 69 IAALLCV 75
>XP_005254198
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           A+LC QY
Sbjct: 165 AILCWQY 171
>XP_005248624
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   VAAVLCVQ 8
           VAAV C Q
Sbjct: 388 VAAVACAQ 395
>NP_038265
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  VAAVLCV 7
          +AA+LCV
Sbjct: 69 IAALLCV 75
>NP_001096640
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   VAAVLCVQ 8
           +AAV+C Q
Sbjct: 198 IAAVVCQQ 205
>NP_002461
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           ++ C+QY
Sbjct: 811 SIFCIQY 817
>NP_054865
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VAAVLCVQ 8
          VAA LCV+
Sbjct: 20 VAASLCVR 27
>NP_006775
          Length = 943

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   VLCVQY 9
           VLCV Y
Sbjct: 552 VLCVSY 557
>NP_005954
          Length = 1939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           ++ C+QY
Sbjct: 814 SIFCIQY 820
>NP_115852
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VAAVLCVQ 8
          VAA LCV+
Sbjct: 20 VAASLCVR 27
>NP_115853
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VAAVLCVQ 8
          VAA LCV+
Sbjct: 20 VAASLCVR 27
>NP_003793
          Length = 1938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           ++ C+QY
Sbjct: 814 SIFCIQY 820
>NP_060003
          Length = 1939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           ++ C+QY
Sbjct: 814 SIFCIQY 820
>XP_006722202
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  AAVLCVQY 9
          AAVLC  +
Sbjct: 3  AAVLCASF 10
>XP_005257794
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  AAVLCVQY 9
          AAVLC  +
Sbjct: 61 AAVLCASF 68
>XP_005256707
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           ++ C+QY
Sbjct: 815 SIFCIQY 821
>XP_006721591
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 6/7 (85%)

Query: 3   AVLCVQY 9
           ++ C+QY
Sbjct: 811 SIFCIQY 817
>XP_005250619
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  VAAVLCVQ 8
          VAA LCV+
Sbjct: 20 VAASLCVR 27
>XP_005263968
          Length = 1861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4  VLCVQY 9
          +LC++Y
Sbjct: 84 ILCIEY 89
>XP_005263967
          Length = 1899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4  VLCVQY 9
          +LC++Y
Sbjct: 84 ILCIEY 89
>XP_005263966
          Length = 1900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 4  VLCVQY 9
          +LC++Y
Sbjct: 84 ILCIEY 89
>NP_115752
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  AAVLCVQY 9
          AAVLC  +
Sbjct: 61 AAVLCASF 68
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.138    0.435 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 587,980
Number of extensions: 817
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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