Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              22     134
NP_001263689                                                           22     134
NP_001119584                                                           22     134
NP_001119586                                                           22     134
NP_001263625                                                           22     134
NP_001119590                                                           22     134
NP_001263690                                                           22     134
NP_001119585                                                           22     134
NP_001263624                                                           22     134
NP_443152                                                              17    2528
XP_006711992                                                           17    2528
NP_066553                                                              17    2528
NP_071433                                                              17    3301
NP_001243624                                                           17    4312
NP_001619                                                              16    5631
NP_689854                                                              16    5631
XP_006719336                                                           16    5631
XP_006719335                                                           16    5631
XP_006717558                                                           16    5631
XP_006717557                                                           16    5631
XP_006717556                                                           16    5631
XP_005252630                                                           16    5631
XP_005252629                                                           16    5631
XP_005252628                                                           16    5631
XP_005252627                                                           16    5631
XP_005252625                                                           16    5631
XP_005252623                                                           16    5631
XP_006717555                                                           16    5631
XP_005252621                                                           16    5631
XP_005250291                                                           16    5631
NP_001007279                                                           16    7355
NP_434698                                                              16    7355
NP_998755                                                              16    7355
NP_005789                                                              16    7355
NP_073622                                                              16    7355
XP_006724360                                                           16    7355
XP_006724359                                                           16    7355
XP_005261762                                                           16    7355
XP_005261761                                                           16    7355
XP_005265300                                                           16    7355
XP_005265299                                                           16    7355
XP_005265298                                                           16    7355
NP_942153                                                              16    7355
NP_002411                                                              15    9605
NP_001238953                                                           15    9605
NP_001238949                                                           15    9605
NP_003165                                                              15    9605
NP_068506                                                              15    9605
NP_001241663                                                           15    9605
NP_001098998                                                           15    9605
NP_945346                                                              15    9605
NP_945345                                                              15    9605
NP_003624                                                              15    9605
NP_001243503                                                           15    9605
NP_001243505                                                           15    9605
NP_001243504                                                           15    9605
NP_683692                                                              15    9605
XP_006717559                                                           15    9605
XP_005252626                                                           15    9605
XP_005252624                                                           15    9605
XP_005252622                                                           15    9605
XP_005248208                                                           15    9605
XP_005248207                                                           15    9605
XP_006714021                                                           15    9605
NP_002931                                                              15    9605
NP_001035809                                                           15    9605
NP_003657                                                              15    9605
>NP_000537
          Length = 393

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TYSPAVNKM 9
           TYSPA+NKM
Sbjct: 125 TYSPALNKM 133
>NP_001263689
          Length = 354

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TYSPAVNKM 9
          TYSPA+NKM
Sbjct: 86 TYSPALNKM 94
>NP_001119584
          Length = 393

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TYSPAVNKM 9
           TYSPA+NKM
Sbjct: 125 TYSPALNKM 133
>NP_001119586
          Length = 341

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TYSPAVNKM 9
           TYSPA+NKM
Sbjct: 125 TYSPALNKM 133
>NP_001263625
          Length = 302

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TYSPAVNKM 9
          TYSPA+NKM
Sbjct: 86 TYSPALNKM 94
>NP_001119590
          Length = 354

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TYSPAVNKM 9
          TYSPA+NKM
Sbjct: 86 TYSPALNKM 94
>NP_001263690
          Length = 354

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TYSPAVNKM 9
          TYSPA+NKM
Sbjct: 86 TYSPALNKM 94
>NP_001119585
          Length = 346

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   TYSPAVNKM 9
           TYSPA+NKM
Sbjct: 125 TYSPALNKM 133
>NP_001263624
          Length = 307

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  TYSPAVNKM 9
          TYSPA+NKM
Sbjct: 86 TYSPALNKM 94
>NP_443152
          Length = 875

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TYSPAVN 7
           T+SPAVN
Sbjct: 171 TFSPAVN 177
>XP_006711992
          Length = 875

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   TYSPAVN 7
           T+SPAVN
Sbjct: 171 TFSPAVN 177
>NP_066553
          Length = 473

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  TYSPAVNK 8
          +Y PAVNK
Sbjct: 85 SYPPAVNK 92
>NP_071433
          Length = 196

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  SPAVNKM 9
          +PAVNKM
Sbjct: 75 TPAVNKM 81
>NP_001243624
          Length = 1177

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YSPAVNKM 9
           YSP +N+M
Sbjct: 520 YSPTLNEM 527
>NP_001619
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YSPAVNKM 9
           Y PAVN++
Sbjct: 178 YKPAVNQI 185
>NP_689854
          Length = 1835

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   TYSPAVNKM 9
           TY+PA++++
Sbjct: 938 TYAPAIHQI 946
>XP_006719336
          Length = 1779

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   TYSPAVNKM 9
           TY+PA++++
Sbjct: 882 TYAPAIHQI 890
>XP_006719335
          Length = 1793

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   TYSPAVNKM 9
           TY+PA++++
Sbjct: 938 TYAPAIHQI 946
>XP_006717558
          Length = 1908

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TYSPAV 6
           TYSPA+
Sbjct: 847 TYSPAI 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 523 FSPAVN 528
>XP_006717557
          Length = 1940

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TYSPAV 6
           TYSPA+
Sbjct: 879 TYSPAI 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 555 FSPAVN 560
>XP_006717556
          Length = 2024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TYSPAV 6
           TYSPA+
Sbjct: 963 TYSPAI 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 639 FSPAVN 644
>XP_005252630
          Length = 2256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    TYSPAV 6
            TYSPA+
Sbjct: 1195 TYSPAI 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 871 FSPAVN 876
>XP_005252629
          Length = 2256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    TYSPAV 6
            TYSPA+
Sbjct: 1195 TYSPAI 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 871 FSPAVN 876
>XP_005252628
          Length = 2256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    TYSPAV 6
            TYSPA+
Sbjct: 1195 TYSPAI 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 871 FSPAVN 876
>XP_005252627
          Length = 2256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    TYSPAV 6
            TYSPA+
Sbjct: 1195 TYSPAI 1200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 871 FSPAVN 876
>XP_005252625
          Length = 2277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    TYSPAV 6
            TYSPA+
Sbjct: 1216 TYSPAI 1221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 892 FSPAVN 897
>XP_005252623
          Length = 2302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    TYSPAV 6
            TYSPA+
Sbjct: 1241 TYSPAI 1246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 917 FSPAVN 922
>XP_006717555
          Length = 2328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    TYSPAV 6
            TYSPA+
Sbjct: 1267 TYSPAI 1272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 943 FSPAVN 948
>XP_005252621
          Length = 2334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    TYSPAV 6
            TYSPA+
Sbjct: 1273 TYSPAI 1278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 949 FSPAVN 954
>XP_005250291
          Length = 172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  YSPAVNKM 9
          Y PAVN++
Sbjct: 34 YKPAVNQI 41
>NP_001007279
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YSPAVNKM 9
           Y P +NK+
Sbjct: 218 YDPEINKL 225
>NP_434698
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YSPAVNKM 9
           Y P +NK+
Sbjct: 215 YDPEINKL 222
>NP_998755
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YSPAVNKM 9
           Y P +NK+
Sbjct: 215 YDPEINKL 222
>NP_005789
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YSPAVNKM 9
           Y P +NK+
Sbjct: 215 YDPEINKL 222
>NP_073622
          Length = 1501

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YSPAVNK 8
           YSPAV++
Sbjct: 916 YSPAVHR 922
>XP_006724360
          Length = 885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YSPAVNK 8
           YSPAV++
Sbjct: 214 YSPAVHR 220
>XP_006724359
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YSPAVNK 8
           YSPAV++
Sbjct: 916 YSPAVHR 922
>XP_005261762
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YSPAVNK 8
           YSPAV++
Sbjct: 810 YSPAVHR 816
>XP_005261761
          Length = 1587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YSPAVNK 8
           YSPAV++
Sbjct: 916 YSPAVHR 922
>XP_005265300
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  TYSPAVNK 8
          T+SP+++K
Sbjct: 12 TFSPSISK 19
>XP_005265299
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  TYSPAVNK 8
          T+SP+++K
Sbjct: 12 TFSPSISK 19
>XP_005265298
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  TYSPAVNK 8
          T+SP+++K
Sbjct: 12 TFSPSISK 19
>NP_942153
          Length = 1349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   YSPAVNK 8
           YSPAV++
Sbjct: 764 YSPAVHR 770
>NP_002411
          Length = 1603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TYSPAVNK 8
            T SP++NK
Sbjct: 1376 TISPSLNK 1383
>NP_001238953
          Length = 1625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TYSPAVNK 8
            T SP++NK
Sbjct: 1398 TISPSLNK 1405
>NP_001238949
          Length = 1642

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    TYSPAVNK 8
            T SP++NK
Sbjct: 1415 TISPSLNK 1422
>NP_003165
          Length = 1788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 445 FSPAVN 450
>NP_068506
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 871 FSPAVN 876
>NP_001241663
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YSPAVNKM 9
           YS AVN++
Sbjct: 454 YSKAVNRL 461
>NP_001098998
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SPAVNKM 9
          +P VNKM
Sbjct: 93 APCVNKM 99
>NP_945346
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SPAVNKM 9
          +P VNKM
Sbjct: 93 APCVNKM 99
>NP_945345
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   YSPAVNKM 9
           YS AVN++
Sbjct: 454 YSKAVNRL 461
>NP_003624
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   YSPAVNK 8
           Y P +NK
Sbjct: 417 YDPTINK 423
>NP_001243503
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   YSPAVNK 8
           Y P +NK
Sbjct: 417 YDPTINK 423
>NP_001243505
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   YSPAVNK 8
           Y P +NK
Sbjct: 344 YDPTINK 350
>NP_001243504
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 5/7 (71%)

Query: 2   YSPAVNK 8
           Y P +NK
Sbjct: 417 YDPTINK 423
>NP_683692
          Length = 3051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYSPAVNK 8
           T+SP +NK
Sbjct: 103 TWSPHLNK 110
>XP_006717559
          Length = 1866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 523 FSPAVN 528
>XP_005252626
          Length = 2260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 917 FSPAVN 922
>XP_005252624
          Length = 2292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 949 FSPAVN 954
>XP_005252622
          Length = 2308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YSPAVN 7
           +SPAVN
Sbjct: 949 FSPAVN 954
>XP_005248208
          Length = 3097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYSPAVNK 8
           T+SP +NK
Sbjct: 103 TWSPHLNK 110
>XP_005248207
          Length = 3098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYSPAVNK 8
           T+SP +NK
Sbjct: 103 TWSPHLNK 110
>XP_006714021
          Length = 3112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   TYSPAVNK 8
           T+SP +NK
Sbjct: 103 TWSPHLNK 110
>NP_002931
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YSPAVNKM 9
           Y P +NK+
Sbjct: 573 YRPRINKL 580
>NP_001035809
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   YSPAVNKM 9
           Y P +NK+
Sbjct: 573 YRPRINKL 580
>NP_003657
          Length = 400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   TYSPAV 6
           TYSP+V
Sbjct: 282 TYSPSV 287
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.116    0.325 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 688,017
Number of extensions: 1037
Number of successful extensions: 78
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 78
Number of HSP's successfully gapped: 78
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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